New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes Article Swipe
Angelo Maria Patti
,
Rosaria Vincenza Giglio
,
Marcello Ciaccio
,
Anca Pantea Stoian
,
Teodor Salmen
,
Cristina Bică
,
Imran Rashid Rangraze
,
Mohamed El‐Tanani
,
Manfredi Rizzo
,
Ali A. Rizvi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/medicina61040664
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/medicina61040664
The heterogeneity among patients with obesity is particularly evident in the weight loss response to interventions such as diets, drugs, devices and surgery. Obesity can be “catalogued” into four phenotypes: hungry brain (abnormal satiety for alteration of gut–brain axis), emotional hunger (hedonic eating), hungry gut (abnormal duration of satiety for faster gastric emptying) and slow burning (slowing of the metabolic rate). Phenotypes are grafted onto this complexity, the recognition of which allows for personalized medicine and increasingly targeted therapies. Although there are no standardized treatment protocols, we present management options consisting of lifestyle modifications and pharmacologic therapies. Nutritional advice and encouragement of adequate physical activity lead to increased self-efficacy and promote a sense of well-being when coupled with psychological approaches involving mindful eating. In summary, obesity has a complex pathophysiology best addressed through a therapeutic process suited to the phenotype encountered and in synergy with multifactorial interventions.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/medicina61040664
- https://www.mdpi.com/1648-9144/61/4/664/pdf?version=1743689537
- OA Status
- gold
- Cited By
- 4
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409152825
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409152825Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/medicina61040664Digital Object Identifier
- Title
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New Frontiers in Nutritional and Therapeutic Interventions for Obesity PhenotypesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-03Full publication date if available
- Authors
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Angelo Maria Patti, Rosaria Vincenza Giglio, Marcello Ciaccio, Anca Pantea Stoian, Teodor Salmen, Cristina Bică, Imran Rashid Rangraze, Mohamed El‐Tanani, Manfredi Rizzo, Ali A. RizviList of authors in order
- Landing page
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https://doi.org/10.3390/medicina61040664Publisher landing page
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https://www.mdpi.com/1648-9144/61/4/664/pdf?version=1743689537Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1648-9144/61/4/664/pdf?version=1743689537Direct OA link when available
- Concepts
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Psychological intervention, Obesity, Weight loss, Phenotype, Medicine, Personalized medicine, Bioinformatics, Weight management, Lifestyle modification, Intensive care medicine, Psychology, Neuroscience, Psychiatry, Internal medicine, Biology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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70Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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