New Glass-Ceramics in the System Ca2SiO4-Ca3(PO4)2—Phase Composition, Microstructure, and Effect on the Cell Viability Article Swipe
Irena Mihailova
,
Petya Dimitrova
,
Georgi Avdeev
,
Radostina Ivanova
,
Hristo Georgiev
,
Milena Nedkova-Shtipska
,
Ralitsa Teodosieva
,
Lachezar Radev
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ma18163887
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/ma18163887
The CaO-SiO2-P2O5 system is one of the main systems studied aiming for the synthesis of new bioactive materials for bone regeneration. The interest in materials containing calcium-phosphate-silicate phases is determined by their biocompatibility, biodegradability, bioactivity, and osseointegration. The object of the present study is the synthesis by the sol-gel method of biocompatible glass-ceramics in the Ca2SiO4-Ca3(PO4)2 subsystem with the composition 6Ca2SiO4·Ca3(PO4)2 = Ca15(PO4)2(SiO4)6. The phase-structural evolution of the samples was monitored using X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and surface area analysis. A powder (20–30 µm) glass-ceramic material containing fine crystalline aggregates of dicalcium silicate and plates of silicon-substituted hydroxyapatite was obtained after heat treatment at 700 °C. After heat treatment at 1200 °C, Ca15(PO4)2(SiO4)6, silicocarnotite Ca5(PO4)2(SiO4), and pseudowollastonite CaSiO3 were identified by XRD, and the particle size varied between 20 and 70 µm. The compact glass-ceramic obtained at 1400 °C contained Ca2SiO4-Ca3(PO4)2 solid solutions with an α-Ca2SiO4 structure as a main crystalline phase. SEM showed the specific morphology of the crystalline phases and illustrated the trend of increasing particle size depending on the synthesis temperature. Effects of the glass-ceramic materials on cell viability of HL-60-derived osteoclast-like cells and on the expression of apoptotic and osteoclast-driven marker suggested that all materials at low concentrations, above 1 µg mL−1, are biocompatible, and S-1400 might have a potential application as a scaffold material for bone regeneration.
Related Topics
Concepts
Materials science
Ceramic
Microstructure
Chemical engineering
Biocompatibility
Scanning electron microscope
Fourier transform infrared spectroscopy
Glass-ceramic
Phase (matter)
Bioactive glass
Energy-dispersive X-ray spectroscopy
Particle size
Mineralogy
Composite material
Chemistry
Metallurgy
Organic chemistry
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ma18163887
- https://www.mdpi.com/1996-1944/18/16/3887/pdf?version=1755618265
- OA Status
- gold
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413358875
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413358875Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ma18163887Digital Object Identifier
- Title
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New Glass-Ceramics in the System Ca2SiO4-Ca3(PO4)2—Phase Composition, Microstructure, and Effect on the Cell ViabilityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-19Full publication date if available
- Authors
-
Irena Mihailova, Petya Dimitrova, Georgi Avdeev, Radostina Ivanova, Hristo Georgiev, Milena Nedkova-Shtipska, Ralitsa Teodosieva, Lachezar RadevList of authors in order
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https://doi.org/10.3390/ma18163887Publisher landing page
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https://www.mdpi.com/1996-1944/18/16/3887/pdf?version=1755618265Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1996-1944/18/16/3887/pdf?version=1755618265Direct OA link when available
- Concepts
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Materials science, Ceramic, Microstructure, Chemical engineering, Biocompatibility, Scanning electron microscope, Fourier transform infrared spectroscopy, Glass-ceramic, Phase (matter), Bioactive glass, Energy-dispersive X-ray spectroscopy, Particle size, Mineralogy, Composite material, Chemistry, Metallurgy, Organic chemistry, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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67Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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