New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System Article Swipe

PDF

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.3389/fmolb.2020.555372

RNA modifications termed epitranscriptomics represent an additional layer of gene regulation similar to epigenetic mechanisms operating on DNA. The dynamic nature and the increasing number of RNA modifications offer new opportunities for a rapid fine-tuning of gene expression in response to specific environmental cues. In cooperation with a diverse and versatile set of effector proteins that "recognize" them, these RNA modifications have the ability to mediate and control diverse fundamental cellular functions, such as pre-mRNA splicing, nuclear export, stability, and translation. N ⁶-methyladenosine (m⁶A) is the most abundant of these RNA modifications, particularly in the nervous system, where recent studies have highlighted it as an important post-transcriptional regulator of physiological functions from development to synaptic plasticity, learning and memory. Here we review recent findings surrounding the role of m⁶A modification in regulating physiological responses of the mammalian nervous system and we discuss its emerging role in pathological conditions such as neuropsychiatric and neurodegenerative disorders.

Related Topics

Computational Biology

Catechol-O-Methyltransferase

Concepts

N6-Methyladenosine RNA methylation Methylation Physiology Biology RNA Nervous system Neuroscience Pathology Medicine Bioinformatics Computational biology Methyltransferase Genetics Gene

Metadata

Type: review
Language: en
Landing Page: https://doi.org/10.3389/fmolb.2020.555372
PDF: https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf
OA Status: gold
Cited By: 32
References: 159
Related Works: 10
OpenAlex ID: https://openalex.org/W3082903791

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W3082903791

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.3389/fmolb.2020.555372

Digital Object Identifier
Title: New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

Work title
Type: review

OpenAlex work type
Language: en

Primary language
Publication year: 2020

Year of publication
Publication date: 2020-09-02

Full publication date if available
Authors: Georgia Dermentzaki, Francesco Lotti

List of authors in order
Landing page: https://doi.org/10.3389/fmolb.2020.555372

Publisher landing page
PDF URL: https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf

Direct OA link when available
Concepts: N6-Methyladenosine, RNA methylation, Methylation, Physiology, Biology, RNA, Nervous system, Neuroscience, Pathology, Medicine, Bioinformatics, Computational biology, Methyltransferase, Genetics, Gene

Top concepts (fields/topics) attached by OpenAlex
Cited by: 32

Total citation count in OpenAlex
Citations by year (recent): 2025: 2, 2024: 7, 2023: 4, 2022: 5, 2021: 14

Per-year citation counts (last 5 years)
References (count): 159

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W3082903791
doi	https://doi.org/10.3389/fmolb.2020.555372
ids.doi	https://doi.org/10.3389/fmolb.2020.555372
ids.mag	3082903791
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/32984403
ids.openalex	https://openalex.org/W3082903791
fwci	2.63322827
type	review
title	New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System
awards[0].id	https://openalex.org/G5478824420
awards[0].funder_id	https://openalex.org/F4320332161
awards[0].display_name
awards[0].funder_award_id	R21NS101575
awards[0].funder_display_name	National Institutes of Health
biblio.issue
biblio.volume	7
biblio.last_page	555372
biblio.first_page	555372
topics[0].id	https://openalex.org/T11482
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1312
topics[0].subfield.display_name	Molecular Biology
topics[0].display_name	RNA modifications and cancer
topics[1].id	https://openalex.org/T10515
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9972000122070312
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1306
topics[1].subfield.display_name	Cancer Research
topics[1].display_name	Cancer-related molecular mechanisms research
topics[2].id	https://openalex.org/T10604
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9724000096321106
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1312
topics[2].subfield.display_name	Molecular Biology
topics[2].display_name	RNA Research and Splicing
funders[0].id	https://openalex.org/F4320332161
funders[0].ror	https://ror.org/01cwqze88
funders[0].display_name	National Institutes of Health
is_xpac	False
apc_list.value	2490
apc_list.currency	USD
apc_list.value_usd	2490
apc_paid.value	2490
apc_paid.currency	USD
apc_paid.value_usd	2490
concepts[0].id	https://openalex.org/C2775963939
concepts[0].level	5
concepts[0].score	0.8609400987625122
concepts[0].wikidata	https://www.wikidata.org/wiki/Q6951996
concepts[0].display_name	N6-Methyladenosine
concepts[1].id	https://openalex.org/C2909856833
concepts[1].level	5
concepts[1].score	0.6934419274330139
concepts[1].wikidata	https://www.wikidata.org/wiki/Q518328
concepts[1].display_name	RNA methylation
concepts[2].id	https://openalex.org/C33288867
concepts[2].level	3
concepts[2].score	0.5880241990089417
concepts[2].wikidata	https://www.wikidata.org/wiki/Q518328
concepts[2].display_name	Methylation
concepts[3].id	https://openalex.org/C42407357
concepts[3].level	1
concepts[3].score	0.5126937627792358
concepts[3].wikidata	https://www.wikidata.org/wiki/Q521
concepts[3].display_name	Physiology
concepts[4].id	https://openalex.org/C86803240
concepts[4].level	0
concepts[4].score	0.5088856220245361
concepts[4].wikidata	https://www.wikidata.org/wiki/Q420
concepts[4].display_name	Biology
concepts[5].id	https://openalex.org/C67705224
concepts[5].level	3
concepts[5].score	0.46578943729400635
concepts[5].wikidata	https://www.wikidata.org/wiki/Q11053
concepts[5].display_name	RNA
concepts[6].id	https://openalex.org/C545706735
concepts[6].level	2
concepts[6].score	0.4603462219238281
concepts[6].wikidata	https://www.wikidata.org/wiki/Q9404
concepts[6].display_name	Nervous system
concepts[7].id	https://openalex.org/C169760540
concepts[7].level	1
concepts[7].score	0.4482901692390442
concepts[7].wikidata	https://www.wikidata.org/wiki/Q207011
concepts[7].display_name	Neuroscience
concepts[8].id	https://openalex.org/C142724271
concepts[8].level	1
concepts[8].score	0.34692323207855225
concepts[8].wikidata	https://www.wikidata.org/wiki/Q7208
concepts[8].display_name	Pathology
concepts[9].id	https://openalex.org/C71924100
concepts[9].level	0
concepts[9].score	0.3435322642326355
concepts[9].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[9].display_name	Medicine
concepts[10].id	https://openalex.org/C60644358
concepts[10].level	1
concepts[10].score	0.32157838344573975
concepts[10].wikidata	https://www.wikidata.org/wiki/Q128570
concepts[10].display_name	Bioinformatics
concepts[11].id	https://openalex.org/C70721500
concepts[11].level	1
concepts[11].score	0.32140448689460754
concepts[11].wikidata	https://www.wikidata.org/wiki/Q177005
concepts[11].display_name	Computational biology
concepts[12].id	https://openalex.org/C91965660
concepts[12].level	4
concepts[12].score	0.1600223183631897
concepts[12].wikidata	https://www.wikidata.org/wiki/Q415875
concepts[12].display_name	Methyltransferase
concepts[13].id	https://openalex.org/C54355233
concepts[13].level	1
concepts[13].score	0.13525134325027466
concepts[13].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[13].display_name	Genetics
concepts[14].id	https://openalex.org/C104317684
concepts[14].level	2
concepts[14].score	0.09525209665298462
concepts[14].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[14].display_name	Gene
keywords[0].id	https://openalex.org/keywords/n6-methyladenosine
keywords[0].score	0.8609400987625122
keywords[0].display_name	N6-Methyladenosine
keywords[1].id	https://openalex.org/keywords/rna-methylation
keywords[1].score	0.6934419274330139
keywords[1].display_name	RNA methylation
keywords[2].id	https://openalex.org/keywords/methylation
keywords[2].score	0.5880241990089417
keywords[2].display_name	Methylation
keywords[3].id	https://openalex.org/keywords/physiology
keywords[3].score	0.5126937627792358
keywords[3].display_name	Physiology
keywords[4].id	https://openalex.org/keywords/biology
keywords[4].score	0.5088856220245361
keywords[4].display_name	Biology
keywords[5].id	https://openalex.org/keywords/rna
keywords[5].score	0.46578943729400635
keywords[5].display_name	RNA
keywords[6].id	https://openalex.org/keywords/nervous-system
keywords[6].score	0.4603462219238281
keywords[6].display_name	Nervous system
keywords[7].id	https://openalex.org/keywords/neuroscience
keywords[7].score	0.4482901692390442
keywords[7].display_name	Neuroscience
keywords[8].id	https://openalex.org/keywords/pathology
keywords[8].score	0.34692323207855225
keywords[8].display_name	Pathology
keywords[9].id	https://openalex.org/keywords/medicine
keywords[9].score	0.3435322642326355
keywords[9].display_name	Medicine
keywords[10].id	https://openalex.org/keywords/bioinformatics
keywords[10].score	0.32157838344573975
keywords[10].display_name	Bioinformatics
keywords[11].id	https://openalex.org/keywords/computational-biology
keywords[11].score	0.32140448689460754
keywords[11].display_name	Computational biology
keywords[12].id	https://openalex.org/keywords/methyltransferase
keywords[12].score	0.1600223183631897
keywords[12].display_name	Methyltransferase
keywords[13].id	https://openalex.org/keywords/genetics
keywords[13].score	0.13525134325027466
keywords[13].display_name	Genetics
keywords[14].id	https://openalex.org/keywords/gene
keywords[14].score	0.09525209665298462
keywords[14].display_name	Gene
language	en
locations[0].id	doi:10.3389/fmolb.2020.555372
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S2595797843
locations[0].source.issn	2296-889X
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2296-889X
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Frontiers in Molecular Biosciences
locations[0].source.host_organization	https://openalex.org/P4310320527
locations[0].source.host_organization_name	Frontiers Media
locations[0].source.host_organization_lineage	https://openalex.org/P4310320527
locations[0].source.host_organization_lineage_names	Frontiers Media
locations[0].license	cc-by
locations[0].pdf_url	https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Frontiers in Molecular Biosciences
locations[0].landing_page_url	https://doi.org/10.3389/fmolb.2020.555372
locations[1].id	pmid:32984403
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Frontiers in molecular biosciences
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/32984403
locations[2].id	pmh:oai:doaj.org/article:2362480f9d0c4f9bacaabcab493de3b3
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306401280
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[2].source.host_organization
locations[2].source.host_organization_name
locations[2].license	cc-by-sa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	article
locations[2].license_id	https://openalex.org/licenses/cc-by-sa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name	Frontiers in Molecular Biosciences, Vol 7 (2020)
locations[2].landing_page_url	https://doaj.org/article/2362480f9d0c4f9bacaabcab493de3b3
locations[3].id	pmh:oai:pubmedcentral.nih.gov:7492240
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S2764455111
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	PubMed Central
locations[3].source.host_organization	https://openalex.org/I1299303238
locations[3].source.host_organization_name	National Institutes of Health
locations[3].source.host_organization_lineage	https://openalex.org/I1299303238
locations[3].license	cc-by
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	Text
locations[3].license_id	https://openalex.org/licenses/cc-by
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Front Mol Biosci
locations[3].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/7492240
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5089360309
authorships[0].author.orcid
authorships[0].author.display_name	Georgia Dermentzaki
authorships[0].countries	US
authorships[0].affiliations[0].institution_ids	https://openalex.org/I78577930
authorships[0].affiliations[0].raw_affiliation_string	Department of Neurology, Columbia University, New York City, NY, United States
authorships[0].affiliations[1].institution_ids	https://openalex.org/I78577930
authorships[0].affiliations[1].raw_affiliation_string	Center for Motor Neuron Biology and Disease, Department of Pathology and Cell Biology, Columbia University, New York City, NY, United States
authorships[0].institutions[0].id	https://openalex.org/I78577930
authorships[0].institutions[0].ror	https://ror.org/00hj8s172
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I78577930
authorships[0].institutions[0].country_code	US
authorships[0].institutions[0].display_name	Columbia University
authorships[0].author_position	first
authorships[0].raw_author_name	Georgia Dermentzaki
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Center for Motor Neuron Biology and Disease, Department of Pathology and Cell Biology, Columbia University, New York City, NY, United States, Department of Neurology, Columbia University, New York City, NY, United States
authorships[1].author.id	https://openalex.org/A5061632778
authorships[1].author.orcid	https://orcid.org/0000-0002-5104-9088
authorships[1].author.display_name	Francesco Lotti
authorships[1].countries	US
authorships[1].affiliations[0].institution_ids	https://openalex.org/I78577930
authorships[1].affiliations[0].raw_affiliation_string	Department of Neurology, Columbia University, New York City, NY, United States
authorships[1].affiliations[1].institution_ids	https://openalex.org/I78577930
authorships[1].affiliations[1].raw_affiliation_string	Center for Motor Neuron Biology and Disease, Department of Pathology and Cell Biology, Columbia University, New York City, NY, United States
authorships[1].institutions[0].id	https://openalex.org/I78577930
authorships[1].institutions[0].ror	https://ror.org/00hj8s172
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I78577930
authorships[1].institutions[0].country_code	US
authorships[1].institutions[0].display_name	Columbia University
authorships[1].author_position	last
authorships[1].raw_author_name	Francesco Lotti
authorships[1].is_corresponding	True
authorships[1].raw_affiliation_strings	Center for Motor Neuron Biology and Disease, Department of Pathology and Cell Biology, Columbia University, New York City, NY, United States, Department of Neurology, Columbia University, New York City, NY, United States
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2020-09-08T00:00:00
display_name	New Insights on the Role of N6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11482
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1312
primary_topic.subfield.display_name	Molecular Biology
primary_topic.display_name	RNA modifications and cancer
related_works	https://openalex.org/W3017034535, https://openalex.org/W4405087519, https://openalex.org/W4237083789, https://openalex.org/W2505116771, https://openalex.org/W4308415202, https://openalex.org/W2916807836, https://openalex.org/W4296034215, https://openalex.org/W4404039273, https://openalex.org/W4393151738, https://openalex.org/W4379796893
cited_by_count	32
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	2
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	7
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	4
counts_by_year[3].year	2022
counts_by_year[3].cited_by_count	5
counts_by_year[4].year	2021
counts_by_year[4].cited_by_count	14
locations_count	4
best_oa_location.id	doi:10.3389/fmolb.2020.555372
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2595797843
best_oa_location.source.issn	2296-889X
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2296-889X
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Frontiers in Molecular Biosciences
best_oa_location.source.host_organization	https://openalex.org/P4310320527
best_oa_location.source.host_organization_name	Frontiers Media
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320527
best_oa_location.source.host_organization_lineage_names	Frontiers Media
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Frontiers in Molecular Biosciences
best_oa_location.landing_page_url	https://doi.org/10.3389/fmolb.2020.555372
primary_location.id	doi:10.3389/fmolb.2020.555372
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S2595797843
primary_location.source.issn	2296-889X
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2296-889X
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Frontiers in Molecular Biosciences
primary_location.source.host_organization	https://openalex.org/P4310320527
primary_location.source.host_organization_name	Frontiers Media
primary_location.source.host_organization_lineage	https://openalex.org/P4310320527
primary_location.source.host_organization_lineage_names	Frontiers Media
primary_location.license	cc-by
primary_location.pdf_url	https://www.frontiersin.org/articles/10.3389/fmolb.2020.555372/pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Frontiers in Molecular Biosciences
primary_location.landing_page_url	https://doi.org/10.3389/fmolb.2020.555372
publication_date	2020-09-02
publication_year	2020
referenced_works	https://openalex.org/W2595114003, https://openalex.org/W2409671300, https://openalex.org/W1895681508, https://openalex.org/W2041328373, https://openalex.org/W2309333134, https://openalex.org/W2769807951, https://openalex.org/W2007429249, https://openalex.org/W1988249495, https://openalex.org/W2915489297, https://openalex.org/W2093071388, https://openalex.org/W6638054149, https://openalex.org/W2961329072, https://openalex.org/W2754983795, https://openalex.org/W2947033479, https://openalex.org/W2035905956, https://openalex.org/W2921237984, https://openalex.org/W1586245300, https://openalex.org/W2767387920, https://openalex.org/W2108663777, https://openalex.org/W2085106808, https://openalex.org/W2063798177, https://openalex.org/W2463137216, https://openalex.org/W2065847836, https://openalex.org/W2892071256, https://openalex.org/W2507685096, https://openalex.org/W2570634615, https://openalex.org/W2522085729, https://openalex.org/W2962876356, https://openalex.org/W2752985760, https://openalex.org/W2762766159, https://openalex.org/W2952723565, https://openalex.org/W1617816798, https://openalex.org/W2092207134, https://openalex.org/W2084588717, https://openalex.org/W3026751717, https://openalex.org/W2055898909, https://openalex.org/W2965293347, https://openalex.org/W2950063384, https://openalex.org/W2953460056, https://openalex.org/W2169494000, https://openalex.org/W2002458471, https://openalex.org/W2564558365, https://openalex.org/W2754807156, https://openalex.org/W3008232393, https://openalex.org/W2086158309, https://openalex.org/W2958352462, https://openalex.org/W2015696149, https://openalex.org/W1840450113, https://openalex.org/W2151327690, https://openalex.org/W2055747883, https://openalex.org/W2991175285, https://openalex.org/W2749219966, https://openalex.org/W3011765028, https://openalex.org/W2793785833, https://openalex.org/W2071930821, https://openalex.org/W2117062466, https://openalex.org/W2073396144, https://openalex.org/W1599304786, https://openalex.org/W1965286266, https://openalex.org/W1972885007, https://openalex.org/W4211222744, https://openalex.org/W2810357757, https://openalex.org/W2029803700, https://openalex.org/W2578506026, https://openalex.org/W2969891751, https://openalex.org/W2807565449, https://openalex.org/W2342299314, https://openalex.org/W2898866333, https://openalex.org/W776567260, https://openalex.org/W2022770379, https://openalex.org/W1840322263, https://openalex.org/W2741037975, https://openalex.org/W1981629946, https://openalex.org/W2589225545, https://openalex.org/W1819978819, https://openalex.org/W2992866845, https://openalex.org/W2805506311, https://openalex.org/W2903232633, https://openalex.org/W2990551615, https://openalex.org/W2012215886, https://openalex.org/W2889993050, https://openalex.org/W2003969692, https://openalex.org/W2809946987, https://openalex.org/W1764846306, https://openalex.org/W2608560932, https://openalex.org/W2175514210, https://openalex.org/W2078964320, https://openalex.org/W2773937672, https://openalex.org/W2525809657, https://openalex.org/W2936853956, https://openalex.org/W2001985726, https://openalex.org/W2928211142, https://openalex.org/W2509465044, https://openalex.org/W2616848081, https://openalex.org/W2147372806, https://openalex.org/W1973571832, https://openalex.org/W2091235283, https://openalex.org/W2595455544, https://openalex.org/W2015963210, https://openalex.org/W2056712149, https://openalex.org/W2960264922, https://openalex.org/W2764301500, https://openalex.org/W2613267149, https://openalex.org/W1910374374, https://openalex.org/W2123824748, https://openalex.org/W2102872651, https://openalex.org/W3008777472, https://openalex.org/W2575691519, https://openalex.org/W2946217053, https://openalex.org/W2899339826, https://openalex.org/W2131331811, https://openalex.org/W2520925527, https://openalex.org/W2011852020, https://openalex.org/W2913117464, https://openalex.org/W2888342366, https://openalex.org/W2032162800, https://openalex.org/W2776310795, https://openalex.org/W4210589768, https://openalex.org/W2136530026, https://openalex.org/W2151054505, https://openalex.org/W2588142072, https://openalex.org/W2805826733, https://openalex.org/W2472887612, https://openalex.org/W1991807334, https://openalex.org/W1941339056, https://openalex.org/W2009308529, https://openalex.org/W2783571957, https://openalex.org/W2891713480, https://openalex.org/W2885706121, https://openalex.org/W2791790309, https://openalex.org/W2963951592, https://openalex.org/W2782731154, https://openalex.org/W2805799552, https://openalex.org/W2472332159, https://openalex.org/W6738694991, https://openalex.org/W2902945209, https://openalex.org/W2269054226, https://openalex.org/W2085278634, https://openalex.org/W2760498857, https://openalex.org/W2769856951, https://openalex.org/W3006863847, https://openalex.org/W2791349417, https://openalex.org/W3029046617, https://openalex.org/W2972933339, https://openalex.org/W2941225619, https://openalex.org/W2306179365, https://openalex.org/W6753434618, https://openalex.org/W2600626962, https://openalex.org/W1974124243, https://openalex.org/W2897208044, https://openalex.org/W2015217788, https://openalex.org/W2165547003, https://openalex.org/W3005655659, https://openalex.org/W2164852392, https://openalex.org/W1933156045, https://openalex.org/W2921211860, https://openalex.org/W2885321095, https://openalex.org/W2620642044, https://openalex.org/W1976844911
referenced_works_count	159
abstract_inverted_index.a	32, 47
abstract_inverted_index.In	44
abstract_inverted_index.an	5, 104
abstract_inverted_index.as	73, 103, 149
abstract_inverted_index.in	38, 93, 130, 145
abstract_inverted_index.is	84
abstract_inverted_index.it	102
abstract_inverted_index.of	8, 25, 35, 52, 88, 108, 127, 134
abstract_inverted_index.on	16
abstract_inverted_index.to	12, 40, 64, 113
abstract_inverted_index.we	120, 140
abstract_inverted_index.RNA	0, 26, 59, 90
abstract_inverted_index.The	18
abstract_inverted_index.and	21, 49, 66, 79, 117, 139, 151
abstract_inverted_index.for	31
abstract_inverted_index.its	142
abstract_inverted_index.new	29
abstract_inverted_index.set	51
abstract_inverted_index.the	22, 62, 85, 94, 125, 135
abstract_inverted_index.DNA.	17
abstract_inverted_index.Here	119
abstract_inverted_index.from	111
abstract_inverted_index.gene	9, 36
abstract_inverted_index.have	61, 100
abstract_inverted_index.most	86
abstract_inverted_index.role	126, 144
abstract_inverted_index.such	72, 148
abstract_inverted_index.that	55
abstract_inverted_index.with	46
abstract_inverted_index.cues.	43
abstract_inverted_index.layer	7
abstract_inverted_index.offer	28
abstract_inverted_index.rapid	33
abstract_inverted_index.them,	57
abstract_inverted_index.these	58, 89
abstract_inverted_index.where	97
abstract_inverted_index.nature	20
abstract_inverted_index.number	24
abstract_inverted_index.recent	98, 122
abstract_inverted_index.review	121
abstract_inverted_index.system	138
abstract_inverted_index.termed	2
abstract_inverted_index.ability	63
abstract_inverted_index.control	67
abstract_inverted_index.discuss	141
abstract_inverted_index.diverse	48, 68
abstract_inverted_index.dynamic	19
abstract_inverted_index.export,	77
abstract_inverted_index.mediate	65
abstract_inverted_index.memory.	118
abstract_inverted_index.nervous	95, 137
abstract_inverted_index.nuclear	76
abstract_inverted_index.similar	11
abstract_inverted_index.studies	99
abstract_inverted_index.system,	96
abstract_inverted_index.<i>N</i>	81
abstract_inverted_index.abundant	87
abstract_inverted_index.cellular	70
abstract_inverted_index.effector	53
abstract_inverted_index.emerging	143
abstract_inverted_index.findings	123
abstract_inverted_index.learning	116
abstract_inverted_index.pre-mRNA	74
abstract_inverted_index.proteins	54
abstract_inverted_index.response	39
abstract_inverted_index.specific	41
abstract_inverted_index.synaptic	114
abstract_inverted_index.functions	110
abstract_inverted_index.important	105
abstract_inverted_index.mammalian	136
abstract_inverted_index.operating	15
abstract_inverted_index.regulator	107
abstract_inverted_index.represent	4
abstract_inverted_index.responses	133
abstract_inverted_index.splicing,	75
abstract_inverted_index.versatile	50
abstract_inverted_index.additional	6
abstract_inverted_index.conditions	147
abstract_inverted_index.disorders.	153
abstract_inverted_index.epigenetic	13
abstract_inverted_index.expression	37
abstract_inverted_index.functions,	71
abstract_inverted_index.increasing	23
abstract_inverted_index.mechanisms	14
abstract_inverted_index.regulating	131
abstract_inverted_index.regulation	10
abstract_inverted_index.stability,	78
abstract_inverted_index."recognize"	56
abstract_inverted_index.cooperation	45
abstract_inverted_index.development	112
abstract_inverted_index.fine-tuning	34
abstract_inverted_index.fundamental	69
abstract_inverted_index.highlighted	101
abstract_inverted_index.plasticity,	115
abstract_inverted_index.surrounding	124
abstract_inverted_index.modification	129
abstract_inverted_index.particularly	92
abstract_inverted_index.pathological	146
abstract_inverted_index.translation.	80
abstract_inverted_index.environmental	42
abstract_inverted_index.modifications	1, 27, 60
abstract_inverted_index.opportunities	30
abstract_inverted_index.physiological	109, 132
abstract_inverted_index.m<sup>6</sup>A	128
abstract_inverted_index.modifications,	91
abstract_inverted_index.(m<sup>6</sup>A)	83
abstract_inverted_index.neuropsychiatric	150
abstract_inverted_index.neurodegenerative	152
abstract_inverted_index.epitranscriptomics	3
abstract_inverted_index.post-transcriptional	106
abstract_inverted_index.<sup>6</sup>-methyladenosine	82
cited_by_percentile_year.max	99
cited_by_percentile_year.min	95
corresponding_author_ids	https://openalex.org/A5061632778
countries_distinct_count	1
institutions_distinct_count	2
corresponding_institution_ids	https://openalex.org/I78577930
citation_normalized_percentile.value	0.8964325
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True