New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways Article Swipe
Maria Grazia Signorello
,
Federica Rapetti
,
Elda Meta
,
Adama Sidibé
,
Olga Bruno
,
Chiara Brullo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26195735
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/molecules26195735
(1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potency; (2) Methods: here, a new small compound library, endowed with the same differently decorated chemical scaffolds, has been synthetized to obtain new agents able to inhibit different pathways involved in inflammation, cancer and human platelet aggregation. (3) Results: most of the new synthesized derivatives resulted able to block ROS production, platelet aggregation and p38MAPK phosphorylation both in platelets and Human Umbilical Vein Endothelial cells (HUVEC). This paves the way for the development of new agents with anti-angiogenic activity.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules26195735
- https://www.mdpi.com/1420-3049/26/19/5735/pdf?version=1632637455
- OA Status
- gold
- Cited By
- 9
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3201074595
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3201074595Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules26195735Digital Object Identifier
- Title
-
New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation PathwaysWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-22Full publication date if available
- Authors
-
Maria Grazia Signorello, Federica Rapetti, Elda Meta, Adama Sidibé, Olga Bruno, Chiara BrulloList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules26195735Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/26/19/5735/pdf?version=1632637455Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/26/19/5735/pdf?version=1632637455Direct OA link when available
- Concepts
-
Umbilical vein, Phosphorylation, Inflammation, Chemistry, Cancer, Platelet aggregation, Platelet, Protein kinase B, Cancer research, Potency, Cancer cell, Pyrazole, Pharmacology, Biochemistry, Stereochemistry, Biology, Immunology, In vitro, Medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 3, 2022: 3Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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