New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegration Article Swipe
Pengzhen Gu
,
Zhijing Wen
,
Lifeng Bao
,
Yibin Wang
,
Pengrong Ouyang
,
Teng Lu
,
Jialiang Li
,
Jiaxi Li
,
Meng Jiang
,
Na Li
,
Xiangcheng Zhang
,
Jian Wu
,
Xijing He
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.matdes.2022.111283
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.matdes.2022.111283
PEKK has good biocompatibility as an implantable material, but its mechanical properties and osseointegration are not satisfied enough. Aluminum oxide (Al2O3) is highly wear-resistant, while hydroxyapatite (HA) is a biologically active. However all previous biocomposites made via mechanical mixing of these two bioceramic materials have not been able to meet clinical standards. The aim of this work is to resolve these problems by using newly synthesized bioceramic hybrids. In vitro and in vivo experiments have demonstrated that these new biomaterials have significantly improved biocompatibility and biomechanical properties when compared to neat PEKK. Surface sulfonation of the hybrids also leads to further improvements of these two properties. S-PEKK/Al2O3 and S-PEKK/HA promote MC3T3-E1 adhesion. PEKK/HA and S-PEKK/HA significantly promote cell proliferation by upregulating both mRNA and protein levels of cell cycle genes to facilitate cells shift from G0/G1 phase to S phase. PEKK/HA hybrids and S-PEKK/Al2O3 promote cell differentiation by upregulating the expression of osteogenic differentiation genes and proteins. PEKK/HA, S-PEKK/Al2O3 and S-PEKK/HA are able to strongly bind to the new bone and exhibit good in vivo osseointegration properties. We conclude that PEKK/HA, S-PEKK/Al2O3 and S-PEKK/HA show good osteogenic ability, especially S-PEKK/HA, and could be promising materials for bone implants.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.matdes.2022.111283
- OA Status
- gold
- Cited By
- 9
- References
- 47
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4307055242Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.matdes.2022.111283Digital Object Identifier
- Title
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New synthetic PEKK/bioceramic hybrids and their surface sulfonation counterparts have increased cellular osteogenic capacity and promoted osseointegrationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-10-21Full publication date if available
- Authors
-
Pengzhen Gu, Zhijing Wen, Lifeng Bao, Yibin Wang, Pengrong Ouyang, Teng Lu, Jialiang Li, Jiaxi Li, Meng Jiang, Na Li, Xiangcheng Zhang, Jian Wu, Xijing HeList of authors in order
- Landing page
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https://doi.org/10.1016/j.matdes.2022.111283Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.matdes.2022.111283Direct OA link when available
- Concepts
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Osseointegration, Bioceramic, Materials science, Biocompatibility, Surface modification, Composite material, Implant, Chemical engineering, Metallurgy, Medicine, Engineering, SurgeryTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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