Newly identified loci that influence lipid concentrations and risk of coronary artery disease Article Swipe

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Cristen J. Willer , Serena Sanna , Anne Jackson , Angelo Scuteri , Lori L. Bonnycastle , Robert Clarke , Simon Heath , Nicholas J. Timpson , Samer S. Najjar , Heather M. Stringham , James Strait , William L. Duren , Andrea Maschio , Fabio Busonero , Antonella Mulas , Giuseppe Albai , Amy J. Swift , Mario A. Morken , Narisu Narisu , Derrick Bennett , Sarah Parish , Haiqing Shen , Pilar Galán , Pierre Meneton , Serge Herçberg , Diana Zélénika , Wei-Min Chen , Yun Li , Laura J. Scott , Paul Scheet , Jouko Sundvall , Richard M. Watanabe , Ramaiah Nagaraja , Shah Ebrahim , Debbie A. Lawlor , Yoav Ben‐Shlomo , George Davey Smith , Alan R. Shuldiner , Rory Collins , Richard N. Bergman , Manuela Uda , Jaakko Tuomilehto , Antonio Cao , Francis S. Collins , Edward G. Lakatta , G.M. Lathrop , Michael Boehnke , David Schlessinger , Karen L. Mohlke , Gonçalo R. Abecasis ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.17615/kfwc-pe72

To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables) and 2,758 individuals from the Diabetes Genetics Initiative, reported in a companion study in this issue. We subsequently examined promising signals in 11,569 additional individuals. Overall, we identify strongly associated variants in eleven loci previously implicated in lipid metabolism (ABCA1, the APOA5-APOA4-APOC3-APOA1 and APOE-APOC clusters, APOB, CETP, GCKR, LDLR, LPL, LIPC, LIPG and PCSK9) and also in several newly identified loci (near MVK-MMAB and GALNT2, with variants primarily associated with high-density lipoprotein (HDL) cholesterol; near SORT1, with variants primarily associated with low-density lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides and LDL cholesterol). Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls.

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Coronary Artery Disease

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Coronary artery disease Internal medicine Cardiology Disease Medicine Biology

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Type: article
Language: en
Landing Page: https://doi.org/10.17615/kfwc-pe72
OA Status: green
Related Works: 10
OpenAlex ID: https://openalex.org/W4298249387

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DOI: https://doi.org/10.17615/kfwc-pe72

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Title: Newly identified loci that influence lipid concentrations and risk of coronary artery disease

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Type: article

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Language: en

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Publication year: 2019

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Publication date: 2019-08-17

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Authors: Cristen J. Willer, Serena Sanna, Anne Jackson, Angelo Scuteri, Lori L. Bonnycastle, Robert Clarke, Simon Heath, Nicholas J. Timpson, Samer S. Najjar, Heather M. Stringham, James Strait, William L. Duren, Andrea Maschio, Fabio Busonero, Antonella Mulas, Giuseppe Albai, Amy J. Swift, Mario A. Morken, Narisu Narisu, Derrick Bennett, Sarah Parish, Haiqing Shen, Pilar Galán, Pierre Meneton, Serge Herçberg, Diana Zélénika, Wei-Min Chen, Yun Li, Laura J. Scott, Paul Scheet, Jouko Sundvall, Richard M. Watanabe, Ramaiah Nagaraja, Shah Ebrahim, Debbie A. Lawlor, Yoav Ben‐Shlomo, George Davey Smith, Alan R. Shuldiner, Rory Collins, Richard N. Bergman, Manuela Uda, Jaakko Tuomilehto, Antonio Cao, Francis S. Collins, Edward G. Lakatta, G.M. Lathrop, Michael Boehnke, David Schlessinger, Karen L. Mohlke, Gonçalo R. Abecasis

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Landing page: https://doi.org/10.17615/kfwc-pe72

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Concepts: Coronary artery disease, Internal medicine, Cardiology, Disease, Medicine, Biology

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