NFX1‐123: A potential therapeutic target in cervical cancer Article Swipe
Sreenivasulu Chintala
,
Maura A. Dankoski
,
Anand Anbarasu
,
Sudha Ramaiah
,
Sravan Kumar Miryala
,
Rachel A. Katzenellenbogen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/jmv.28856
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/jmv.28856
NFX1‐123 is a splice variant isoform of the NFX1 gene. It is highly expressed in cervical cancers caused by HPV, and NFX1‐123 is a protein partner with the HPV oncoprotein E6. Together, NFX1‐123 and E6 affect cellular growth, longevity, and differentiation. The expression status of NFX1‐123 in cancers beyond cervical and head and neck cancers, and its potential as therapeutic target, have not been investigated. TSVdb of TCGA was used to quantify NFX1‐123 expression in 24 cancers compared with normal tissues. The NFX1‐123 protein structure was predicted and then submitted to retrieve suitable drug molecules. The top four compounds, found to bind in silico to NFX1‐123, were tested experimentally to determine their effects on NFX1‐123‐related cellular growth, survival, and migration. 46% of cancers (11 of 24 had significant differences in NFX1‐123 expression, with nine having had greater NFX1‐123 expression, when compared with adjacent normal tissues. Bioinformatics and proteomic predictive analysis modeled the three‐dimensional structure of NFX1‐123, and drug libraries were screened for high‐binding affinity compounds using this modeled structure. Seventeen drugs with binding energies ranging from −1.3 to −10 Kcal/mol were identified. The top four compounds were used to treat HPV‐ and HPV+ cervical cancer cell lines, three of which (Ropitoin, R428 and Ketoconazole) reduced NFX1‐123 protein levels, inhibited cellular growth, survival, and migration, and enhanced the cytotoxicity of Cisplatin. These findings highlight cancers expressing high levels of NFX1‐123, and drugs that target it, may reduce cellular growth, survival, and migration, making NFX1‐123 a potential novel therapeutic target.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jmv.28856
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.28856
- OA Status
- hybrid
- Cited By
- 4
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4379769357
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4379769357Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/jmv.28856Digital Object Identifier
- Title
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NFX1‐123: A potential therapeutic target in cervical cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-01Full publication date if available
- Authors
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Sreenivasulu Chintala, Maura A. Dankoski, Anand Anbarasu, Sudha Ramaiah, Sravan Kumar Miryala, Rachel A. KatzenellenbogenList of authors in order
- Landing page
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https://doi.org/10.1002/jmv.28856Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.28856Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.28856Direct OA link when available
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Cervical cancer, Cancer research, Biology, In silico, Cisplatin, Growth inhibition, Cell culture, Cancer, Gene, Chemotherapy, GeneticsTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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