Nicotine Administration Exacerbates Lipid Profile Alterations in a Wistar Rat Model of Liver Fibrosis Through Fatty Acid Synthesis Modulation Article Swipe

PDF

Narges Dastmalchi , Khalil Hajiasgharzadeh , Hooria Amooji , Mohammad Reza Alipour , Majid Ahmadi , Behzad Mansoori , Homeira Hatami Nemati , Seyed Mahdi Banan Khojasteh ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-6646003/v1

Dyslipidemia is characterized by abnormal lipid levels in the bloodstream and can be influenced by liver diseases and smoking. Nicotine exposure and liver damage are linked to lipid metabolism impairments. This study investigated the effects of nicotine on dyslipidemia in a cholestasis rat model using bile duct ligation (BDL) to establish liver fibrosis. Wistar rats received intraperitoneal nicotine at doses of 10 mg/kg (high) and 1 mg/kg (low) for three weeks. Serum levels of triglycerides (TG), cholesterol (Chol), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were quantified via a standard colorimetric kit (Pars Azmoon). Liver fibrosis confirmed through histological investigation. Additionally, the mRNA and protein expression of fatty acid synthase (FAS) were assessed using quantitative RT-PCR and immunofluorescence. Results showed that nicotine administration in healthy rats significantly increased TG, Chol, and LDL levels while decreasing HDL. In BDL rats, nicotine further reduced HDL and increased TG levels without affecting Chol and LDL. Histological analysis confirmed hepatic fibrosis, and both nicotine exposure and liver fibrosis elevated FAS expression in liver tissues. These findings indicate that BDL-induced liver fibrosis causes dyslipidemia in rats, and nicotine exposure exacerbates serum lipid profile alterations, potentially through increased FAS expression. Therefore, it is recommended that individuals with liver disease avoid nicotine to manage dyslipidemia.

Related Topics

Concepts

Fatty liver Liver fibrosis Nicotine Chemistry Rat model Fatty acid Modulation (music) Pharmacology Fibrosis Endocrinology Internal medicine Medicine Biochemistry Physics Acoustics Disease

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.21203/rs.3.rs-6646003/v1
PDF: https://www.researchsquare.com/article/rs-6646003/latest.pdf
OA Status: gold
Related Works: 10
OpenAlex ID: https://openalex.org/W4410485074

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4410485074

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.21203/rs.3.rs-6646003/v1

Digital Object Identifier
Title: Nicotine Administration Exacerbates Lipid Profile Alterations in a Wistar Rat Model of Liver Fibrosis Through Fatty Acid Synthesis Modulation

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2025

Year of publication
Publication date: 2025-05-19

Full publication date if available
Authors: Narges Dastmalchi, Khalil Hajiasgharzadeh, Hooria Amooji, Mohammad Reza Alipour, Majid Ahmadi, Behzad Mansoori, Homeira Hatami Nemati, Seyed Mahdi Banan Khojasteh

List of authors in order
Landing page: https://doi.org/10.21203/rs.3.rs-6646003/v1

Publisher landing page
PDF URL: https://www.researchsquare.com/article/rs-6646003/latest.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://www.researchsquare.com/article/rs-6646003/latest.pdf

Direct OA link when available
Concepts: Fatty liver, Liver fibrosis, Nicotine, Chemistry, Rat model, Fatty acid, Modulation (music), Pharmacology, Fibrosis, Endocrinology, Internal medicine, Medicine, Biochemistry, Physics, Acoustics, Disease

Top concepts (fields/topics) attached by OpenAlex
Cited by: 0

Total citation count in OpenAlex
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4410485074
doi	https://doi.org/10.21203/rs.3.rs-6646003/v1
ids.doi	https://doi.org/10.21203/rs.3.rs-6646003/v1
ids.openalex	https://openalex.org/W4410485074
fwci	0.0
type	preprint
title	Nicotine Administration Exacerbates Lipid Profile Alterations in a Wistar Rat Model of Liver Fibrosis Through Fatty Acid Synthesis Modulation
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10351
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9345999956130981
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2713
topics[0].subfield.display_name	Epidemiology
topics[0].display_name	Liver Disease Diagnosis and Treatment
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C2778772119
concepts[0].level	3
concepts[0].score	0.5807839632034302
concepts[0].wikidata	https://www.wikidata.org/wiki/Q6058862
concepts[0].display_name	Fatty liver
concepts[1].id	https://openalex.org/C2994217296
concepts[1].level	3
concepts[1].score	0.5578210353851318
concepts[1].wikidata	https://www.wikidata.org/wiki/Q147778
concepts[1].display_name	Liver fibrosis
concepts[2].id	https://openalex.org/C2779547902
concepts[2].level	2
concepts[2].score	0.538558304309845
concepts[2].wikidata	https://www.wikidata.org/wiki/Q28086552
concepts[2].display_name	Nicotine
concepts[3].id	https://openalex.org/C185592680
concepts[3].level	0
concepts[3].score	0.521743893623352
concepts[3].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[3].display_name	Chemistry
concepts[4].id	https://openalex.org/C3019114686
concepts[4].level	2
concepts[4].score	0.47062399983406067
concepts[4].wikidata	https://www.wikidata.org/wiki/Q3089676
concepts[4].display_name	Rat model
concepts[5].id	https://openalex.org/C543025807
concepts[5].level	2
concepts[5].score	0.45810556411743164
concepts[5].wikidata	https://www.wikidata.org/wiki/Q61476
concepts[5].display_name	Fatty acid
concepts[6].id	https://openalex.org/C123079801
concepts[6].level	2
concepts[6].score	0.44077977538108826
concepts[6].wikidata	https://www.wikidata.org/wiki/Q750240
concepts[6].display_name	Modulation (music)
concepts[7].id	https://openalex.org/C98274493
concepts[7].level	1
concepts[7].score	0.4364125728607178
concepts[7].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[7].display_name	Pharmacology
concepts[8].id	https://openalex.org/C2780559512
concepts[8].level	2
concepts[8].score	0.4157916307449341
concepts[8].wikidata	https://www.wikidata.org/wiki/Q605709
concepts[8].display_name	Fibrosis
concepts[9].id	https://openalex.org/C134018914
concepts[9].level	1
concepts[9].score	0.412598580121994
concepts[9].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[9].display_name	Endocrinology
concepts[10].id	https://openalex.org/C126322002
concepts[10].level	1
concepts[10].score	0.40142151713371277
concepts[10].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[10].display_name	Internal medicine
concepts[11].id	https://openalex.org/C71924100
concepts[11].level	0
concepts[11].score	0.2945665717124939
concepts[11].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[11].display_name	Medicine
concepts[12].id	https://openalex.org/C55493867
concepts[12].level	1
concepts[12].score	0.29417556524276733
concepts[12].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[12].display_name	Biochemistry
concepts[13].id	https://openalex.org/C121332964
concepts[13].level	0
concepts[13].score	0.12169745564460754
concepts[13].wikidata	https://www.wikidata.org/wiki/Q413
concepts[13].display_name	Physics
concepts[14].id	https://openalex.org/C24890656
concepts[14].level	1
concepts[14].score	0.0
concepts[14].wikidata	https://www.wikidata.org/wiki/Q82811
concepts[14].display_name	Acoustics
concepts[15].id	https://openalex.org/C2779134260
concepts[15].level	2
concepts[15].score	0.0
concepts[15].wikidata	https://www.wikidata.org/wiki/Q12136
concepts[15].display_name	Disease
keywords[0].id	https://openalex.org/keywords/fatty-liver
keywords[0].score	0.5807839632034302
keywords[0].display_name	Fatty liver
keywords[1].id	https://openalex.org/keywords/liver-fibrosis
keywords[1].score	0.5578210353851318
keywords[1].display_name	Liver fibrosis
keywords[2].id	https://openalex.org/keywords/nicotine
keywords[2].score	0.538558304309845
keywords[2].display_name	Nicotine
keywords[3].id	https://openalex.org/keywords/chemistry
keywords[3].score	0.521743893623352
keywords[3].display_name	Chemistry
keywords[4].id	https://openalex.org/keywords/rat-model
keywords[4].score	0.47062399983406067
keywords[4].display_name	Rat model
keywords[5].id	https://openalex.org/keywords/fatty-acid
keywords[5].score	0.45810556411743164
keywords[5].display_name	Fatty acid
keywords[6].id	https://openalex.org/keywords/modulation
keywords[6].score	0.44077977538108826
keywords[6].display_name	Modulation (music)
keywords[7].id	https://openalex.org/keywords/pharmacology
keywords[7].score	0.4364125728607178
keywords[7].display_name	Pharmacology
keywords[8].id	https://openalex.org/keywords/fibrosis
keywords[8].score	0.4157916307449341
keywords[8].display_name	Fibrosis
keywords[9].id	https://openalex.org/keywords/endocrinology
keywords[9].score	0.412598580121994
keywords[9].display_name	Endocrinology
keywords[10].id	https://openalex.org/keywords/internal-medicine
keywords[10].score	0.40142151713371277
keywords[10].display_name	Internal medicine
keywords[11].id	https://openalex.org/keywords/medicine
keywords[11].score	0.2945665717124939
keywords[11].display_name	Medicine
keywords[12].id	https://openalex.org/keywords/biochemistry
keywords[12].score	0.29417556524276733
keywords[12].display_name	Biochemistry
keywords[13].id	https://openalex.org/keywords/physics
keywords[13].score	0.12169745564460754
keywords[13].display_name	Physics
language	en
locations[0].id	doi:10.21203/rs.3.rs-6646003/v1
locations[0].is_oa	True
locations[0].source
locations[0].license	cc-by
locations[0].pdf_url	https://www.researchsquare.com/article/rs-6646003/latest.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.21203/rs.3.rs-6646003/v1
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5060824692
authorships[0].author.orcid	https://orcid.org/0000-0001-6414-4036
authorships[0].author.display_name	Narges Dastmalchi
authorships[0].countries	IR
authorships[0].affiliations[0].institution_ids	https://openalex.org/I4210120856
authorships[0].affiliations[0].raw_affiliation_string	University College of Nabi Akram
authorships[0].institutions[0].id	https://openalex.org/I4210120856
authorships[0].institutions[0].ror	https://ror.org/02kqbjv38
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I4210120856
authorships[0].institutions[0].country_code	IR
authorships[0].institutions[0].display_name	University College of Nabi Akram
authorships[0].author_position	first
authorships[0].raw_author_name	Narges Dastmalchi
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	University College of Nabi Akram
authorships[1].author.id	https://openalex.org/A5012572414
authorships[1].author.orcid	https://orcid.org/0000-0003-4593-4803
authorships[1].author.display_name	Khalil Hajiasgharzadeh
authorships[1].countries	IR
authorships[1].affiliations[0].institution_ids	https://openalex.org/I163205636
authorships[1].affiliations[0].raw_affiliation_string	Tabriz University of Medical Sciences
authorships[1].institutions[0].id	https://openalex.org/I163205636
authorships[1].institutions[0].ror	https://ror.org/04krpx645
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I163205636
authorships[1].institutions[0].country_code	IR
authorships[1].institutions[0].display_name	Tabriz University of Medical Sciences
authorships[1].author_position	middle
authorships[1].raw_author_name	Khalil Hajiasgharzadeh
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Tabriz University of Medical Sciences
authorships[2].author.id	https://openalex.org/A5117592919
authorships[2].author.orcid
authorships[2].author.display_name	Hooria Amooji
authorships[2].countries	IR
authorships[2].affiliations[0].institution_ids	https://openalex.org/I41832843
authorships[2].affiliations[0].raw_affiliation_string	University of Tabriz
authorships[2].institutions[0].id	https://openalex.org/I41832843
authorships[2].institutions[0].ror	https://ror.org/01papkj44
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I41832843
authorships[2].institutions[0].country_code	IR
authorships[2].institutions[0].display_name	University of Tabriz
authorships[2].author_position	middle
authorships[2].raw_author_name	Hooria Amooji
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	University of Tabriz
authorships[3].author.id	https://openalex.org/A5011546352
authorships[3].author.orcid	https://orcid.org/0000-0002-6484-4267
authorships[3].author.display_name	Mohammad Reza Alipour
authorships[3].countries	IR
authorships[3].affiliations[0].institution_ids	https://openalex.org/I163205636
authorships[3].affiliations[0].raw_affiliation_string	Tabriz University of Medical Sciences
authorships[3].institutions[0].id	https://openalex.org/I163205636
authorships[3].institutions[0].ror	https://ror.org/04krpx645
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I163205636
authorships[3].institutions[0].country_code	IR
authorships[3].institutions[0].display_name	Tabriz University of Medical Sciences
authorships[3].author_position	middle
authorships[3].raw_author_name	Mohammad Reza Alipour
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Tabriz University of Medical Sciences
authorships[4].author.id	https://openalex.org/A5076703242
authorships[4].author.orcid	https://orcid.org/0000-0003-4787-5261
authorships[4].author.display_name	Majid Ahmadi
authorships[4].countries	IR
authorships[4].affiliations[0].institution_ids	https://openalex.org/I163205636
authorships[4].affiliations[0].raw_affiliation_string	Tabriz University of Medical Sciences
authorships[4].institutions[0].id	https://openalex.org/I163205636
authorships[4].institutions[0].ror	https://ror.org/04krpx645
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I163205636
authorships[4].institutions[0].country_code	IR
authorships[4].institutions[0].display_name	Tabriz University of Medical Sciences
authorships[4].author_position	middle
authorships[4].raw_author_name	Majid Ahmadi
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Tabriz University of Medical Sciences
authorships[5].author.id	https://openalex.org/A5005400006
authorships[5].author.orcid	https://orcid.org/0000-0001-9444-7134
authorships[5].author.display_name	Behzad Mansoori
authorships[5].countries	US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I102322052
authorships[5].affiliations[0].raw_affiliation_string	The Wistar Institute
authorships[5].institutions[0].id	https://openalex.org/I102322052
authorships[5].institutions[0].ror	https://ror.org/04wncat98
authorships[5].institutions[0].type	facility
authorships[5].institutions[0].lineage	https://openalex.org/I102322052
authorships[5].institutions[0].country_code	US
authorships[5].institutions[0].display_name	The Wistar Institute
authorships[5].author_position	middle
authorships[5].raw_author_name	Behzad Mansoori
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	The Wistar Institute
authorships[6].author.id	https://openalex.org/A5083831170
authorships[6].author.orcid	https://orcid.org/0000-0003-2730-1009
authorships[6].author.display_name	Homeira Hatami Nemati
authorships[6].countries	IR
authorships[6].affiliations[0].institution_ids	https://openalex.org/I41832843
authorships[6].affiliations[0].raw_affiliation_string	University of Tabriz
authorships[6].institutions[0].id	https://openalex.org/I41832843
authorships[6].institutions[0].ror	https://ror.org/01papkj44
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I41832843
authorships[6].institutions[0].country_code	IR
authorships[6].institutions[0].display_name	University of Tabriz
authorships[6].author_position	middle
authorships[6].raw_author_name	Homeira Hatami Nemati
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	University of Tabriz
authorships[7].author.id	https://openalex.org/A5039437580
authorships[7].author.orcid	https://orcid.org/0000-0002-8176-9289
authorships[7].author.display_name	Seyed Mahdi Banan Khojasteh
authorships[7].countries	IR
authorships[7].affiliations[0].institution_ids	https://openalex.org/I41832843
authorships[7].affiliations[0].raw_affiliation_string	University of Tabriz
authorships[7].institutions[0].id	https://openalex.org/I41832843
authorships[7].institutions[0].ror	https://ror.org/01papkj44
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I41832843
authorships[7].institutions[0].country_code	IR
authorships[7].institutions[0].display_name	University of Tabriz
authorships[7].author_position	last
authorships[7].raw_author_name	Seyed Mahdi Banan Khojasteh
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	University of Tabriz
has_content.pdf	True
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.researchsquare.com/article/rs-6646003/latest.pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Nicotine Administration Exacerbates Lipid Profile Alterations in a Wistar Rat Model of Liver Fibrosis Through Fatty Acid Synthesis Modulation
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10351
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9345999956130981
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2713
primary_topic.subfield.display_name	Epidemiology
primary_topic.display_name	Liver Disease Diagnosis and Treatment
related_works	https://openalex.org/W2022981145, https://openalex.org/W2033670595, https://openalex.org/W2332404483, https://openalex.org/W1996479013, https://openalex.org/W1970486150, https://openalex.org/W2047516780, https://openalex.org/W1991718233, https://openalex.org/W2115270048, https://openalex.org/W2390206021, https://openalex.org/W2388854029
cited_by_count	0
locations_count	1
best_oa_location.id	doi:10.21203/rs.3.rs-6646003/v1
best_oa_location.is_oa	True
best_oa_location.source
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.researchsquare.com/article/rs-6646003/latest.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.21203/rs.3.rs-6646003/v1
primary_location.id	doi:10.21203/rs.3.rs-6646003/v1
primary_location.is_oa	True
primary_location.source
primary_location.license	cc-by
primary_location.pdf_url	https://www.researchsquare.com/article/rs-6646003/latest.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.21203/rs.3.rs-6646003/v1
publication_date	2025-05-19
publication_year	2025
referenced_works_count	0
abstract_inverted_index.1	66
abstract_inverted_index.a	41, 89
abstract_inverted_index.10	62
abstract_inverted_index.In	137
abstract_inverted_index.TG	146
abstract_inverted_index.at	59
abstract_inverted_index.be	13
abstract_inverted_index.by	4, 15
abstract_inverted_index.in	8, 40, 124, 168, 180
abstract_inverted_index.is	2, 197
abstract_inverted_index.it	196
abstract_inverted_index.of	36, 61, 74, 107
abstract_inverted_index.on	38
abstract_inverted_index.to	27, 50, 206
abstract_inverted_index.BDL	138
abstract_inverted_index.FAS	166, 193
abstract_inverted_index.HDL	143
abstract_inverted_index.LDL	132
abstract_inverted_index.TG,	129
abstract_inverted_index.and	11, 18, 22, 65, 82, 104, 117, 131, 144, 151, 158, 162, 182
abstract_inverted_index.are	25
abstract_inverted_index.can	12
abstract_inverted_index.for	69
abstract_inverted_index.kit	92
abstract_inverted_index.rat	43
abstract_inverted_index.the	9, 34, 102
abstract_inverted_index.via	88
abstract_inverted_index.Chol	150
abstract_inverted_index.HDL.	136
abstract_inverted_index.LDL.	152
abstract_inverted_index.This	31
abstract_inverted_index.acid	109
abstract_inverted_index.bile	46
abstract_inverted_index.both	159
abstract_inverted_index.duct	47
abstract_inverted_index.mRNA	103
abstract_inverted_index.rats	55, 126
abstract_inverted_index.that	121, 174, 199
abstract_inverted_index.were	86, 112
abstract_inverted_index.with	201
abstract_inverted_index.(BDL)	49
abstract_inverted_index.(FAS)	111
abstract_inverted_index.(HDL)	85
abstract_inverted_index.(Pars	93
abstract_inverted_index.(TG),	76
abstract_inverted_index.(low)	68
abstract_inverted_index.Chol,	130
abstract_inverted_index.Liver	95
abstract_inverted_index.Serum	72
abstract_inverted_index.These	171
abstract_inverted_index.avoid	204
abstract_inverted_index.doses	60
abstract_inverted_index.fatty	108
abstract_inverted_index.lipid	6, 28, 187
abstract_inverted_index.liver	16, 23, 52, 163, 169, 176, 202
abstract_inverted_index.mg/kg	63, 67
abstract_inverted_index.model	44
abstract_inverted_index.rats,	139, 181
abstract_inverted_index.serum	186
abstract_inverted_index.study	32
abstract_inverted_index.three	70
abstract_inverted_index.using	45, 114
abstract_inverted_index.while	134
abstract_inverted_index.(LDL),	81
abstract_inverted_index.(high)	64
abstract_inverted_index.RT-PCR	116
abstract_inverted_index.Wistar	54
abstract_inverted_index.causes	178
abstract_inverted_index.damage	24
abstract_inverted_index.levels	7, 73, 133, 147
abstract_inverted_index.linked	26
abstract_inverted_index.manage	207
abstract_inverted_index.showed	120
abstract_inverted_index.weeks.	71
abstract_inverted_index.(Chol),	78
abstract_inverted_index.Results	119
abstract_inverted_index.disease	203
abstract_inverted_index.effects	35
abstract_inverted_index.further	141
abstract_inverted_index.healthy	125
abstract_inverted_index.hepatic	156
abstract_inverted_index.profile	188
abstract_inverted_index.protein	105
abstract_inverted_index.reduced	142
abstract_inverted_index.through	98, 191
abstract_inverted_index.without	148
abstract_inverted_index.Azmoon).	94
abstract_inverted_index.Nicotine	20
abstract_inverted_index.abnormal	5
abstract_inverted_index.analysis	154
abstract_inverted_index.assessed	113
abstract_inverted_index.diseases	17
abstract_inverted_index.elevated	165
abstract_inverted_index.exposure	21, 161, 184
abstract_inverted_index.fibrosis	96, 164, 177
abstract_inverted_index.findings	172
abstract_inverted_index.indicate	173
abstract_inverted_index.ligation	48
abstract_inverted_index.nicotine	37, 58, 122, 140, 160, 183, 205
abstract_inverted_index.received	56
abstract_inverted_index.smoking.	19
abstract_inverted_index.standard	90
abstract_inverted_index.synthase	110
abstract_inverted_index.tissues.	170
abstract_inverted_index.affecting	149
abstract_inverted_index.confirmed	97, 155
abstract_inverted_index.establish	51
abstract_inverted_index.fibrosis,	157
abstract_inverted_index.fibrosis.	53
abstract_inverted_index.increased	128, 145, 192
abstract_inverted_index.Therefore,	195
abstract_inverted_index.decreasing	135
abstract_inverted_index.expression	106, 167
abstract_inverted_index.influenced	14
abstract_inverted_index.metabolism	29
abstract_inverted_index.quantified	87
abstract_inverted_index.BDL-induced	175
abstract_inverted_index.bloodstream	10
abstract_inverted_index.cholestasis	42
abstract_inverted_index.cholesterol	77
abstract_inverted_index.exacerbates	185
abstract_inverted_index.expression.	194
abstract_inverted_index.individuals	200
abstract_inverted_index.lipoprotein	80, 84
abstract_inverted_index.low-density	79
abstract_inverted_index.potentially	190
abstract_inverted_index.recommended	198
abstract_inverted_index.Dyslipidemia	1
abstract_inverted_index.Histological	153
abstract_inverted_index.alterations,	189
abstract_inverted_index.colorimetric	91
abstract_inverted_index.dyslipidemia	39, 179
abstract_inverted_index.high-density	83
abstract_inverted_index.histological	99
abstract_inverted_index.impairments.	30
abstract_inverted_index.investigated	33
abstract_inverted_index.quantitative	115
abstract_inverted_index.Additionally,	101
abstract_inverted_index.characterized	3
abstract_inverted_index.dyslipidemia.	208
abstract_inverted_index.significantly	127
abstract_inverted_index.triglycerides	75
abstract_inverted_index.administration	123
abstract_inverted_index.investigation.	100
abstract_inverted_index.intraperitoneal	57
abstract_inverted_index.immunofluorescence.	118
abstract_inverted_index.<title>Abstract</title>	0
cited_by_percentile_year
countries_distinct_count	2
institutions_distinct_count	8
citation_normalized_percentile.value	0.24729155
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False