Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis Article Swipe

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Amit Kumar Ram , Balasubramaniyan Vairappan , BH Srinivas ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.3748/wjg.v26.i45.7131

Our current study showed for the first time that nimbolide exhibits anticancer effect by reducing tumor size, tumor burden and by suppressing cell cycle progression in HCC mice. Furthermore, nimbolide treatment to HCC mice ameliorated inflammation and oxidative stress, and improved TJ proteins expression. Consequently, nimbolide could be potentially used as a natural therapeutic agent for HCC treatment, however further human studies are warranted.

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Inflammation Protein expression Tight junction Cancer research Downregulation and upregulation Cell biology Biology Chemistry Medicine Immunology Biochemistry Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.3748/wjg.v26.i45.7131
OA Status: green
Cited By: 16
References: 54
Related Works: 10
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OpenAlex ID: https://openalex.org/W3112440379

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DOI: https://doi.org/10.3748/wjg.v26.i45.7131

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Title: Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis

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Type: article

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Language: en

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Publication year: 2020

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Publication date: 2020-12-04

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Authors: Amit Kumar Ram, Balasubramaniyan Vairappan, BH Srinivas

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Landing page: https://doi.org/10.3748/wjg.v26.i45.7131

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Open access: Yes

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OA status: green

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OA URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7723674

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Concepts: Inflammation, Protein expression, Tight junction, Cancer research, Downregulation and upregulation, Cell biology, Biology, Chemistry, Medicine, Immunology, Biochemistry, Gene

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Cited by: 16

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Citations by year (recent): 2025: 1, 2024: 6, 2023: 1, 2022: 5, 2021: 3

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References (count): 54

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Related works (count): 10

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