Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway Article Swipe
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· 2016
· Open Access
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· DOI: https://doi.org/10.1371/journal.ppat.1005659
The budding of Nipah virus, a deadly member of the Henipavirus genus within the Paramyxoviridae, has been thought to be independent of the host ESCRT pathway, which is critical for the budding of many enveloped viruses. This conclusion was based on the budding properties of the virus matrix protein in the absence of other virus components. Here, we find that the virus C protein, which was previously investigated for its role in antagonism of innate immunity, recruits the ESCRT pathway to promote efficient virus release. Inhibition of ESCRT or depletion of the ESCRT factor Tsg101 abrogates the C enhancement of matrix budding and impairs live Nipah virus release. Further, despite the low sequence homology of the C proteins of known henipaviruses, they all enhance the budding of their cognate matrix proteins, suggesting a conserved and previously unknown function for the henipavirus C proteins.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.ppat.1005659
- https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005659&type=printable
- OA Status
- gold
- Cited By
- 44
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2395119125
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2395119125Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.ppat.1005659Digital Object Identifier
- Title
-
Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent PathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-05-20Full publication date if available
- Authors
-
Arnold Park, Tatyana Yun, Frédéric Vigant, Olivier Pernet, Sohui T. Won, Brian E. Dawes, Bartkowski Wojciech, Alexander N. Freiberg, Benhur LeeList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.ppat.1005659Publisher landing page
- PDF URL
-
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005659&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005659&type=printableDirect OA link when available
- Concepts
-
ESCRT, Viral matrix protein, TSG101, VP40, Virus, Virology, Biology, Budding, Viral envelope, Viral entry, Cell biology, Viral replication, Gene, Genetics, Endosome, microRNA, Microvesicles, IntracellularTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
44Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 2, 2023: 9, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W1982606786, https://openalex.org/W2070709903, https://openalex.org/W2074130602, https://openalex.org/W1965157736, https://openalex.org/W4211200857, https://openalex.org/W4249167162, https://openalex.org/W2037115572, https://openalex.org/W2040706807, https://openalex.org/W2133682271, https://openalex.org/W2136284743, https://openalex.org/W2169388729, https://openalex.org/W2073087719, https://openalex.org/W2143712352, https://openalex.org/W2137979542, https://openalex.org/W2036956826, https://openalex.org/W2155935053, https://openalex.org/W2101005316, https://openalex.org/W2100137876, https://openalex.org/W2170128965, https://openalex.org/W1969126808, https://openalex.org/W2117203473, https://openalex.org/W2003952795, https://openalex.org/W2148809504, https://openalex.org/W2160633099, https://openalex.org/W1803102843, https://openalex.org/W2152689946, https://openalex.org/W2049361058, https://openalex.org/W1605689207, https://openalex.org/W1988754169, https://openalex.org/W2036202997, https://openalex.org/W2124504184, https://openalex.org/W2102891026, https://openalex.org/W2032660967, https://openalex.org/W2160824543, https://openalex.org/W2128536543, https://openalex.org/W1984765070, https://openalex.org/W2001330418, https://openalex.org/W2015937741, https://openalex.org/W2137569894, https://openalex.org/W2323905494, https://openalex.org/W2071559289, https://openalex.org/W2141502554, https://openalex.org/W1998724505, https://openalex.org/W1974807146, https://openalex.org/W2032639010, https://openalex.org/W2171502794, https://openalex.org/W2012828294, https://openalex.org/W2031342118, https://openalex.org/W2105582260, https://openalex.org/W2088990532, https://openalex.org/W1815345423, https://openalex.org/W2005544372 |
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| corresponding_author_ids | https://openalex.org/A5111972158, https://openalex.org/A5022795869, https://openalex.org/A5075526435, https://openalex.org/A5019986056, https://openalex.org/A5081327494, https://openalex.org/A5009227201, https://openalex.org/A5070606892, https://openalex.org/A5026414259, https://openalex.org/A5036629198 |
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