Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure — A systematic review and meta-analysis Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.1016/j.freeradbiomed.2024.11.010
In this study, we conducted a systematic review and meta-analysis to determine plasma and salivary nitrate (NO3-) and nitrite (NO2-) concentrations under resting and fasting conditions in different type of individuals and their association with blood pressure levels. A total of 77 studies, involving 1918 individuals aged 19-74 years (males = 906; females = 1012), which measured plasma and/or salivary NO3- and NO2- using the chemiluminescence technique, were included. Mean plasma NO3- and NO2- concentrations were 33.9 μmol/L and 158.3 nmol/L, respectively. Subgroup analyses revealed lower plasma NO3- and NO2- concentrations in individuals with cardiometabolic risk (NO3-: 21.2 μmol/L; 95 % CI, 13.4-29.0; NO2-: 122.8 nmol/L; 95 % CI, 75.3-138.9) compared to healthy (NO3-: 33.9 μmol/L; 95 % CI, 29.9-37.9; NO2-: 159.5 nmol/L; 95 % CI, 131.8-187.1; P < 0.01) and trained individuals (NO3-: 43.0 μmol/L; 95 % CI, 13.2-72.9; NO2-: 199.3 nmol/L; 95 % CI, 117.6-281; P < 0.01). Mean salivary NO3- and NO2- concentrations were 546.2 μmol/L and 197.8 μmol/L, respectively. Salivary NO3-, but no NO2-, concentrations were higher in individuals with cardiometabolic risk (680.0 μmol/L; 95 % CI, 510.2-849.8; P = 0.001) compared to healthy individuals (535.9 μmol/L; 95 % CI, 384.2-687.6). A significant positive association (coefficient, 15.4 [95 % CI, 0.255 to 30.5], P = 0.046) was observed between salivary NO3- and diastolic blood pressure (DBP). These findings suggest that the health status is positively associated with plasma NO3- and NO2- concentrations, but the circulatory levels of these anions are not associated with blood pressure. Only salivary NO3- showed a significant positive association with DBP.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.freeradbiomed.2024.11.010
- OA Status
- hybrid
- Cited By
- 5
- References
- 151
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404182291
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404182291Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.freeradbiomed.2024.11.010Digital Object Identifier
- Title
-
Nitrate and nitrite bioavailability in plasma and saliva: Their association with blood pressure — A systematic review and meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-08Full publication date if available
- Authors
-
Raúl Bescós, Laura Gallardo-Alfaro, Ammar W. Ashor, Lucía Rizzolo-Brime, Mario Siervo, Patricia Casas‐AgustenchList of authors in order
- Landing page
-
https://doi.org/10.1016/j.freeradbiomed.2024.11.010Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.freeradbiomed.2024.11.010Direct OA link when available
- Concepts
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Meta-analysis, Nitrite, Bioavailability, Saliva, Nitrate, Association (psychology), Chemistry, Medicine, Internal medicine, Psychology, Pharmacology, Organic chemistry, PsychotherapistTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
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151Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.122.8 | 104 |
| abstract_inverted_index.158.3 | 79 |
| abstract_inverted_index.159.5 | 121 |
| abstract_inverted_index.19-74 | 47 |
| abstract_inverted_index.197.8 | 160 |
| abstract_inverted_index.199.3 | 141 |
| abstract_inverted_index.546.2 | 157 |
| abstract_inverted_index.These | 220 |
| abstract_inverted_index.blood | 35, 217, 247 |
| abstract_inverted_index.lower | 85 |
| abstract_inverted_index.their | 32 |
| abstract_inverted_index.these | 241 |
| abstract_inverted_index.total | 39 |
| abstract_inverted_index.under | 21 |
| abstract_inverted_index.using | 63 |
| abstract_inverted_index.which | 55 |
| abstract_inverted_index.years | 48 |
| abstract_inverted_index.(535.9 | 189 |
| abstract_inverted_index.(680.0 | 176 |
| abstract_inverted_index.(DBP). | 219 |
| abstract_inverted_index.(males | 49 |
| abstract_inverted_index.0.001) | 184 |
| abstract_inverted_index.0.01). | 149 |
| abstract_inverted_index.0.046) | 209 |
| abstract_inverted_index.1012), | 54 |
| abstract_inverted_index.30.5], | 206 |
| abstract_inverted_index.and/or | 58 |
| abstract_inverted_index.anions | 242 |
| abstract_inverted_index.health | 225 |
| abstract_inverted_index.higher | 170 |
| abstract_inverted_index.levels | 239 |
| abstract_inverted_index.plasma | 12, 57, 70, 86, 231 |
| abstract_inverted_index.review | 7 |
| abstract_inverted_index.showed | 252 |
| abstract_inverted_index.status | 226 |
| abstract_inverted_index.study, | 2 |
| abstract_inverted_index.between | 212 |
| abstract_inverted_index.fasting | 24 |
| abstract_inverted_index.females | 52 |
| abstract_inverted_index.healthy | 112, 187 |
| abstract_inverted_index.levels. | 37 |
| abstract_inverted_index.nitrate | 15 |
| abstract_inverted_index.nitrite | 18 |
| abstract_inverted_index.nmol/L, | 80 |
| abstract_inverted_index.nmol/L; | 105, 122, 142 |
| abstract_inverted_index.resting | 22 |
| abstract_inverted_index.suggest | 222 |
| abstract_inverted_index.trained | 131 |
| abstract_inverted_index.μmol/L | 77, 158 |
| abstract_inverted_index.Salivary | 163 |
| abstract_inverted_index.Subgroup | 82 |
| abstract_inverted_index.analyses | 83 |
| abstract_inverted_index.compared | 110, 185 |
| abstract_inverted_index.findings | 221 |
| abstract_inverted_index.measured | 56 |
| abstract_inverted_index.observed | 211 |
| abstract_inverted_index.positive | 197, 255 |
| abstract_inverted_index.pressure | 36, 218 |
| abstract_inverted_index.revealed | 84 |
| abstract_inverted_index.salivary | 14, 59, 151, 213, 250 |
| abstract_inverted_index.studies, | 42 |
| abstract_inverted_index.μmol/L, | 161 |
| abstract_inverted_index.μmol/L; | 98, 115, 135, 177, 190 |
| abstract_inverted_index.conducted | 4 |
| abstract_inverted_index.determine | 11 |
| abstract_inverted_index.diastolic | 216 |
| abstract_inverted_index.different | 27 |
| abstract_inverted_index.included. | 68 |
| abstract_inverted_index.involving | 43 |
| abstract_inverted_index.pressure. | 248 |
| abstract_inverted_index.117.6-281; | 146 |
| abstract_inverted_index.13.2-72.9; | 139 |
| abstract_inverted_index.13.4-29.0; | 102 |
| abstract_inverted_index.29.9-37.9; | 119 |
| abstract_inverted_index.associated | 229, 245 |
| abstract_inverted_index.conditions | 25 |
| abstract_inverted_index.positively | 228 |
| abstract_inverted_index.systematic | 6 |
| abstract_inverted_index.technique, | 66 |
| abstract_inverted_index.75.3-138.9) | 109 |
| abstract_inverted_index.association | 33, 198, 256 |
| abstract_inverted_index.circulatory | 238 |
| abstract_inverted_index.individuals | 30, 45, 92, 132, 172, 188 |
| abstract_inverted_index.significant | 196, 254 |
| abstract_inverted_index.131.8-187.1; | 126 |
| abstract_inverted_index.510.2-849.8; | 181 |
| abstract_inverted_index.(coefficient, | 199 |
| abstract_inverted_index.384.2-687.6). | 194 |
| abstract_inverted_index.meta-analysis | 9 |
| abstract_inverted_index.respectively. | 81, 162 |
| abstract_inverted_index.concentrations | 20, 74, 90, 155, 168 |
| abstract_inverted_index.cardiometabolic | 94, 174 |
| abstract_inverted_index.concentrations, | 235 |
| abstract_inverted_index.chemiluminescence | 65 |
| abstract_inverted_index.NO<sub>2</sub><sup>-</sup> | 62, 73, 89, 154, 234 |
| abstract_inverted_index.NO<sub>3</sub><sup>-</sup> | 60, 71, 87, 152, 214, 232, 251 |
| abstract_inverted_index.NO<sub>2</sub><sup>-</sup>, | 167 |
| abstract_inverted_index.NO<sub>2</sub><sup>-</sup>: | 103, 120, 140 |
| abstract_inverted_index.NO<sub>3</sub><sup>-</sup>, | 164 |
| abstract_inverted_index.(NO<sub>2</sub><sup>-</sup>) | 19 |
| abstract_inverted_index.(NO<sub>3</sub><sup>-</sup>) | 16 |
| abstract_inverted_index.(NO<sub>3</sub><sup>-</sup>: | 96, 113, 133 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.88834866 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |