NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.3389/ti.2024.13318
Chronic graft rejection represents a significant threat to long-term graft survival. Early diagnosis, understanding of the immunological mechanisms and appropriate therapeutic management are essential to improve graft survival and quality of life for transplant patients. Knowing which immune cells are responsible for chronic vascular rejection would allow us to provide effective and appropriate treatment for these patients. It is now widely accepted that natural killer (NK) cells play an important role in chronic vascular rejection. They can either initiate chronic vascular rejection by recognizing missing self on the graft or be recruited by donor-specific antibodies to destroy the graft during antibody-mediated rejection. Whatever the mechanisms of activation of NK cells, they need to be primed to become fully activated and damaging to the graft. A better understanding of the signaling pathways involved in NK cell priming and activation would pave the way for the development of new therapeutic strategies to cure chronic vascular rejection. This review examines the critical role of NK cells in the complex context of chronic vascular rejection.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/ti.2024.13318
- OA Status
- gold
- Cited By
- 4
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403476490
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403476490Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/ti.2024.13318Digital Object Identifier
- Title
-
NK Cells: Not Just Followers But Also Initiators of Chronic Vascular RejectionWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-10-16Full publication date if available
- Authors
-
Mathilde Chambon, Alice KoenigList of authors in order
- Landing page
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https://doi.org/10.3389/ti.2024.13318Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/ti.2024.13318Direct OA link when available
- Concepts
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Medicine, Immunology, Context (archaeology), Immune system, Priming (agriculture), Transplant rejection, Biology, Botany, Germination, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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