NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation Article Swipe
Julia Elise Cabral
,
Sophia Lin
,
Haitian Zhou
,
Anna M. Wu
,
A. Lackner
,
Minh Anh Pham
,
F. Chi
,
Reginald McNulty
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.07.642110
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.07.642110
SUMMARY Mitochondrial DNA (mtDNA) release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly. Here, we demonstrate that NLRP3 plays a direct role in cleaving and facilitating the release of D-loop mtDNA into the cytosol. We further show that NLRP3 interacts with NLRP10. NLRP10-mediated ox-DNA cleavage involves a Schiff base intermediate and is inhibited by small molecules known to inhibit glycosylases. These findings support a model where NLRP10 interaction with oxidized DNA may contribute to long-term senescence secretory phenotype and modulate inflammasome activation. Our study highlights a novel mechanism by which NLRP10 can respond to mitochondrial stress signals to influence innate immunity and suggests therapeutic potential for targeting these interactions in inflammatory diseases.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.03.07.642110
- https://www.biorxiv.org/content/biorxiv/early/2025/03/12/2025.03.07.642110.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408404425
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408404425Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.03.07.642110Digital Object Identifier
- Title
-
NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence RegulationWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-12Full publication date if available
- Authors
-
Julia Elise Cabral, Sophia Lin, Haitian Zhou, Anna M. Wu, A. Lackner, Minh Anh Pham, F. Chi, Reginald McNultyList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.03.07.642110Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2025/03/12/2025.03.07.642110.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2025/03/12/2025.03.07.642110.full.pdfDirect OA link when available
- Concepts
-
Inflammasome, Innate immune system, DNA damage, Cell biology, Mitochondrial DNA, Cytosol, DNA, Biology, AIM2, Senescence, DNA glycosylase, Phenotype, Mitochondrion, Chemistry, Biochemistry, Gene, Genetics, Immune system, Enzyme, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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