Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice Article Swipe
Haixia Zhu
,
Hongxiang Wang
,
Dan Wang
,
Shuqiao Liu
,
Xiaoli Sun
,
Zhengjiang Qu
,
Aizhen Zhang
,
Haiping Hao
,
Runze Li
,
Bin Wu
,
Min Liu
,
Jiangang Gao
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-024-07118-2
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-024-07118-2
Cisplatin (CP), a chemotherapy drug commonly used in cancers treatment, causes serious reproductive toxicity. With younger cancer patients and increasing survival rates, it is important to preserve their reproductive capacity. NME8 is highly expressed in testis and contains thioredoxin and NDPK domains, suggesting it may be a target against the CP-induced reproductive toxicity. We deleted exons 6–7 of the Nme8 in mice based on human mutation sites and observed impaired transcript splicing. In mice, Nme8 was not essential for spermatogenesis, possibly due to functional compensation by its paralog, Nme5 . Nme8 expression was elevated and translocated to the nucleus in response to two weeks of CP treatment. Under CP treatment, Nme8 deficiency further impaired antioxidant capacity, induced lipid peroxidation and increased ROS level, and failed to activate autophagy, resulting in aggravated DNA damage in testes and sperm. Consequently, the proliferation and differentiation of spermatogonia and the meiosis of spermatocyte were almost completely halted, and sperm motility was impaired. Our research indicates that NME8 protects against CP-induced testis and sperm damage. This may provide new insights into the physiological functions of the Nme family and potential targets for preserving fertility in young male cancer patients.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-024-07118-2
- https://www.nature.com/articles/s41419-024-07118-2.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403151300
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403151300Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41419-024-07118-2Digital Object Identifier
- Title
-
Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-06Full publication date if available
- Authors
-
Haixia Zhu, Hongxiang Wang, Dan Wang, Shuqiao Liu, Xiaoli Sun, Zhengjiang Qu, Aizhen Zhang, Haiping Hao, Runze Li, Bin Wu, Min Liu, Jiangang GaoList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-024-07118-2Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41419-024-07118-2.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41419-024-07118-2.pdfDirect OA link when available
- Concepts
-
Biology, Spermatogenesis, Cisplatin, Spermatocyte, Sperm, Sperm motility, Toxicity, Cancer research, Reproductive toxicity, DNA damage, Andrology, Cell biology, Internal medicine, Chemotherapy, Meiosis, Endocrinology, Genetics, Gene, Medicine, DNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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