No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT Article Swipe
Sinead Delany‐Moretlwe
,
Hakim‐Moulay Dehbi
,
Izukanji Sikazwe
,
George B. Kyei
,
Kwadwo Koram
,
Erik R. Dubberke
,
Noluthando Mwelase
,
Dominic Hague
,
Linda‐Gail Bekker
,
Linda Yun
,
Annaléne Nel
,
Leon du Toit
,
Bruce Biccard
,
Katherine Gill
,
Chikumbutso Chipeta
,
Kathryn Mngadi
,
Limakatso Lebina
,
Reshmi Dassaye
,
Villeshni Asari
,
Samantha H. Fry
,
Edwin Turton
,
Khatija Ahmed
,
Kwadwo Asamoah Kusi
,
Susan Adu-Amankwah
,
Roma Chilengi
,
Joyce Chilekwa
,
Laurence Lovat
,
Dermot McGuckin
,
Emilia Caverly
,
Mary C. Politi
,
Ben Swan
,
Anne K. DeSchryver
,
Sherry McKinnon
,
Ananya Gupta
,
Gemma Jones
,
Nick Freemantle
,
Shabaana A. Khader
,
Helen Rees
,
Mihai G. Netea
,
Ramani Moonesinghe
,
Michael S. Avidan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1588190
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2025.1588190
Background Measles-containing vaccines (MCV), by training innate immune cells, are hypothesized to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). Methods In this international, double-blind, placebo-controlled trial, we randomly assigned adults, 18 years and older, to receive MCV or saline. The primary outcome was polymerase chain reaction (PCR) confirmed symptomatic COVID-19, up to 60 days after intervention. Secondary outcomes were PCR-confirmed symptomatic COVID-19 and serologically confirmed SARS-CoV-2 infection, up to 150 days after intervention. Results Of 3411 randomised participants, the modified intention-to-treat population included 1607 in the MCV and 1545 in the saline group. The estimated risk of symptomatic COVID-19 by 60 days was 1.5% in the MCV and 1.2% in the saline group (risk difference, 0.3 percentage points, 95% CI, -0.5 to 1.1; p=0.52). At 150 days, these percentages were 4.1% (65/1585) and 4.1% (64/1544) in the MCV and saline groups, respectively (risk difference, 0.04 percentage points, 95% CI, -1.4 to 1.3; p=0.95). Based on serology results available at 0 and 150 days, 10.6% (100/945) of participants in the MCV and 10.3% (98/951) in the saline group had infection with SARS-CoV-2 over the course of the trial (risk difference, 0.3 percentage points, 95% CI, -2.6 to 3.1; p=0.84). Three patients were hospitalised with COVID-19 disease in the MCV and one in the saline group. Conclusions Administering MCVs to stimulate trained immunity did not prevent COVID-19 or SARS-CoV2 infection. Stimulating trained immunity might not be useful for preventing respiratory illness during future pandemics. Clinical trial registration https://clinicaltrials.gov/ , identifier NCT04333732.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2025.1588190
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1588190/pdf
- OA Status
- gold
- References
- 20
- OpenAlex ID
- https://openalex.org/W4414254227
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414254227Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2025.1588190Digital Object Identifier
- Title
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No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCTWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-16Full publication date if available
- Authors
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Sinead Delany‐Moretlwe, Hakim‐Moulay Dehbi, Izukanji Sikazwe, George B. Kyei, Kwadwo Koram, Erik R. Dubberke, Noluthando Mwelase, Dominic Hague, Linda‐Gail Bekker, Linda Yun, Annaléne Nel, Leon du Toit, Bruce Biccard, Katherine Gill, Chikumbutso Chipeta, Kathryn Mngadi, Limakatso Lebina, Reshmi Dassaye, Villeshni Asari, Samantha H. Fry, Edwin Turton, Khatija Ahmed, Kwadwo Asamoah Kusi, Susan Adu-Amankwah, Roma Chilengi, Joyce Chilekwa, Laurence Lovat, Dermot McGuckin, Emilia Caverly, Mary C. Politi, Ben Swan, Anne K. DeSchryver, Sherry McKinnon, Ananya Gupta, Gemma Jones, Nick Freemantle, Shabaana A. Khader, Helen Rees, Mihai G. Netea, Ramani Moonesinghe, Michael S. AvidanList of authors in order
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https://doi.org/10.3389/fimmu.2025.1588190Publisher landing page
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1588190/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1588190/pdfDirect OA link when available
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0Total citation count in OpenAlex
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