No immediate change in systemic cytokines following an eccentric muscle training session in people with multiple sclerosis Article Swipe
Yasmin Alt
,
Monique Wochatz
,
Anne Schraplau
,
Tilman Engel
,
Hadar Sharon
,
Michael Gurevich
,
Shay Menascu
,
F. O. Mayer
,
Alon Kalron
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/17562864241266113
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/17562864241266113
Background: Eccentric muscle contractions elicit distinct physiological responses, including modulation of the cytokine profile. Although relevant for rehabilitation, the effect of eccentric muscle training on the immune system has never been investigated in multiple sclerosis (MS). Objectives: Examine the immediate cytokine response of interleukin-4 (IL-4), IL-6, IL-10, IL-17a, interferon-gamma, and tumor necrosis factor-alpha after a moderate eccentric training session in individuals with MS. Additionally, further investigate the association between systemic cytokine levels at rest and clinical measures of mobility and lower limb functional strength. Design: Observational study. Methods: The first session included blood sampling for baseline cytokine measures. Subsequently, the participant completed a battery of clinical assessments related to mobility and lower limb strength, that is, the Timed-Up-and-Go Test, Five-Repetition-Sit-to-Stand-Test (5STS), Four-Square-Step-Test, and Two-Minute-Walk-Test. The second session included the eccentric exercise training session, followed by a second blood sampling to assess the acute cytokine response to the eccentric training bout. This session comprised 10 exercises concentrating on the strength of the trunk and lower extremities. Results: Twenty-seven people with MS (pwMS), with a mean age of 40.1 years, participated in the study. No difference was demonstrated in the cytokine concentration values between baseline and immediately after the eccentric training session. The 5STS explained 30.3% of the variance associated with interferon-gamma, 14.8% with IL-4, and 13.8% with IL-10. Conclusion: An eccentric training bout does not impact cytokine concentration in the blood and, consequently, does not boost a pro-inflammatory response, thus, it can be performed on pwMS in a rehabilitation setting.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/17562864241266113
- https://journals.sagepub.com/doi/pdf/10.1177/17562864241266113
- OA Status
- gold
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401190438
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4401190438Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/17562864241266113Digital Object Identifier
- Title
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No immediate change in systemic cytokines following an eccentric muscle training session in people with multiple sclerosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
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Yasmin Alt, Monique Wochatz, Anne Schraplau, Tilman Engel, Hadar Sharon, Michael Gurevich, Shay Menascu, F. O. Mayer, Alon KalronList of authors in order
- Landing page
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https://doi.org/10.1177/17562864241266113Publisher landing page
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https://journals.sagepub.com/doi/pdf/10.1177/17562864241266113Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.sagepub.com/doi/pdf/10.1177/17562864241266113Direct OA link when available
- Concepts
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Medicine, Eccentric, Cytokine, Physical medicine and rehabilitation, Multiple sclerosis, Physical therapy, Analysis of variance, Internal medicine, Immunology, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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