Non-antibiotics disrupt colonization resistance against enteropathogens Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1038/s41586-025-09217-2
· OA: W4412479247
Non-antibiotic drugs can alter the composition of the gut microbiome 1 , but they have largely unknown implications for human health 2 . Here we examined how non-antibiotics affect the ability of gut commensals to resist colonization by enteropathogens 3 . We also developed an in vitro assay to assess enteropathogen growth in drug-perturbed microbial communities. Pathogenic Gammaproteobacteria were more resistant to non-antibiotics than commensals and their post-treatment expansion was potentiated. For 28% of the 53 drugs tested, the growth of Salmonella enterica subsp. enterica serovar Typhimurium. ( S . Tm) in synthetic and human stool-derived communities was increased, and similar effects were observed for other enteropathogens. Non-antibiotics promoted pathogen proliferation by inhibiting the growth of commensals, altering microbial interactions and enhancing the ability of S . Tm to exploit metabolic niches. Drugs that promoted pathogen expansion in vitro increased the intestinal S . Tm load in mice. For the antihistamine terfenadine, drug-induced disruption of colonization resistance accelerated disease onset and increased inflammation caused by S . Tm. Our findings identify non-antibiotics as previously overlooked risk factors that may contribute to the development of enteric infections.
