Non-Coding RNAs in Hodgkin Lymphoma Article Swipe
YOU?
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· 2017
· Open Access
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· DOI: https://doi.org/10.3390/ijms18061154
MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression by binding to the 3’-UTR of their target genes, can act as oncogenes or tumor suppressors. Recently, other types of non-coding RNAs—piwiRNAs and long non-coding RNAs—have also been identified. Hodgkin lymphoma (HL) is a B cell origin disease characterized by the presence of only 1% of tumor cells, known as Hodgkin and Reed-Stenberg (HRS) cells, which interact with the microenvironment to evade apoptosis. Several studies have reported specific miRNA signatures that can differentiate HL lymph nodes from reactive lymph nodes, identify histologic groups within classical HL, and distinguish HRS cells from germinal center B cells. Moreover, some signatures are associated with survival or response to chemotherapy. Most of the miRNAs in the signatures regulate genes related to apoptosis, cell cycle arrest, or signaling pathways. Here we review findings on miRNAs in HL, as well as on other non-coding RNAs.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms18061154
- https://www.mdpi.com/1422-0067/18/6/1154/pdf?version=1496142120
- OA Status
- gold
- Cited By
- 18
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2620486423
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https://openalex.org/W2620486423Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/ijms18061154Digital Object Identifier
- Title
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Non-Coding RNAs in Hodgkin LymphomaWork title
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reviewOpenAlex work type
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-05-29Full publication date if available
- Authors
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Anna Cordeiro, Mariano Monzó, Alfons NavarroList of authors in order
- Landing page
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https://doi.org/10.3390/ijms18061154Publisher landing page
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https://www.mdpi.com/1422-0067/18/6/1154/pdf?version=1496142120Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/18/6/1154/pdf?version=1496142120Direct OA link when available
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Hodgkin lymphoma, Lymphoma, Coding (social sciences), Computational biology, Cancer research, Medicine, Biology, Internal medicine, Mathematics, StatisticsTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2024: 3, 2023: 2, 2021: 5, 2020: 2, 2019: 2Per-year citation counts (last 5 years)
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75Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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