Non-coding RNAs modulate function of extracellular matrix proteins Article Swipe
Nader Akbari Dilmaghani
,
Hamed Shoorei
,
Guive Sharifi
,
Mahdi Mohaqiq
,
Jamal Majidpoor
,
Marcel E. Dinger
,
Mohammad Taheri
,
Soudeh Ghafouri‐Fard
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2021.111240
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2021.111240
The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various glycoproteins that collaborate and bind with each other to produce a bioactive polymer. Alterations in the composition and configuration of ECM elements influence the cellular phenotype, thus participating in the pathogenesis of several human disorders. Recent studies indicate the crucial roles of non-coding RNAs in the modulation of ECM. Several miRNAs such as miR-21, miR-26, miR-19, miR-140, miR-29, miR-30, miR-133 have been dysregulated in disorders that are associated with disruption or breakdown of the ECM. Moreover, expression of MALAT1, PVT1, SRA1, n379519, RMRP, PFL, TUG1, TM1P3, FAS-AS1, PART1, XIST, and expression of other lncRNAs is altered in disorders associated with the modification of ECM components. In the current review, we discuss the role of lncRNAs and miRNAs in the modification of ECM and their relevance with the pathophysiology of human disorders such as cardiac/ lung fibrosis, cardiomyopathy, heart failure, asthma, osteoarthritis, and cancers.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2021.111240
- OA Status
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- Cited By
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- OpenAlex ID
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https://openalex.org/W3122349378Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2021.111240Digital Object Identifier
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Non-coding RNAs modulate function of extracellular matrix proteinsWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
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2021-01-19Full publication date if available
- Authors
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Nader Akbari Dilmaghani, Hamed Shoorei, Guive Sharifi, Mahdi Mohaqiq, Jamal Majidpoor, Marcel E. Dinger, Mohammad Taheri, Soudeh Ghafouri‐FardList of authors in order
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https://doi.org/10.1016/j.biopha.2021.111240Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.biopha.2021.111240Direct OA link when available
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Extracellular matrix, microRNA, Cell biology, Biology, Phenotype, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
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60Total citation count in OpenAlex
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2025: 11, 2024: 13, 2023: 16, 2022: 17, 2021: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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