Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort Article Swipe
Viktoria Santner
,
Hermann Riepl
,
Florian Posch
,
Markus Wallner
,
Peter P. Rainer
,
Klemens Ablasser
,
Ewald Kolesnik
,
Viktoria Hoeller
,
David Zach
,
Nora Schwegel
,
Philipp Kreuzer
,
Andreas Lueger
,
Johannes Petutschnigg
,
Burkert Pieske
,
Andreas Zirlik
,
Frank Edelmann
,
Nicolas Verheyen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejim.2023.07.027
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejim.2023.07.027
Pivotal outcome trials targeting heart failure with preserved (HFpEF) and mildly-reduced ejection fraction (HFmrEF) may have excluded patients at highest risk of poor outcomes. We aimed to assess eligibility for HFpEF/HFmrEF outcome trials in an unselected heart failure cohort and its association with all-cause mortality. Among 32.028 patients presenting to a tertiary care center emergency unit for any reason between August 2018 and July 2019, we identified 407 admissions with evident HFpEF and HFmrEF. Eligibility criteria for pivotal trials CHARM-Preserved, I-PRESERVE, TOPCAT, PARAGON-HF, EMPEROR-Preserved and DELIVER were assessed by chart review. The proportions of admissions fulfilling HFpEF/HFmrEF trial eligibility criteria were 88% for CHARM-Preserved, 40% for I-PRESERVE, 35% for TOPCAT, 28% for PARAGON-HF, 51% for EMPEROR-Preserved, and 49% for DELIVER. During a median follow-up of 1.9 years, death-from-any-cause occurred in 121 cases (30%). Twenty-four-month overall survival estimates for non-eligible and eligible admissions were 53% vs. 76% for CHARM-Preserved (HR=2.32, 95% CI: 1.47-3.67, p<0.001), 62% vs. 87% for I-PRESERVE (HR=2.97, 1.85-4.77, p<0.001), 67% vs. 84% for TOPCAT (HR=2.04, 1.29-3.24, p = 0.002), 68% vs. 85% for PARAGONHF (HR=2.28, 1.33-3.90, p = 0.003), 64% vs. 81% for EMPEROR-Preserved (HR=1.90, 1.27-2.84, p = 0.002), and 65% vs. 80% for DELIVER (HR=1.71, 1.14-2.57, p = 0.010). Exclusion criteria independently predicting death were eGFR 2, COPD with home oxygen therapy, and severe valvular heart disease. Conclusively, in a contemporary HFpEF/HFmrEF cohort, non-eligibility for outcome trials predicted for strongly increased mortality. HFpEF/HFmrEF patients at highest mortality risk were likely underrepresented in previous outcome trials and their treatment remains an unmet medical need.
Related Topics
Concepts
Medicine
Heart failure
Internal medicine
Heart failure with preserved ejection fraction
Cohort
Intensive care unit
Ejection fraction
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ejim.2023.07.027
- http://www.ejinme.com/article/S0953620523002583/pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385337038
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4385337038Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ejim.2023.07.027Digital Object Identifier
- Title
-
Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohortWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-28Full publication date if available
- Authors
-
Viktoria Santner, Hermann Riepl, Florian Posch, Markus Wallner, Peter P. Rainer, Klemens Ablasser, Ewald Kolesnik, Viktoria Hoeller, David Zach, Nora Schwegel, Philipp Kreuzer, Andreas Lueger, Johannes Petutschnigg, Burkert Pieske, Andreas Zirlik, Frank Edelmann, Nicolas VerheyenList of authors in order
- Landing page
-
https://doi.org/10.1016/j.ejim.2023.07.027Publisher landing page
- PDF URL
-
https://www.ejinme.com/article/S0953620523002583/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.ejinme.com/article/S0953620523002583/pdfDirect OA link when available
- Concepts
-
Medicine, Heart failure, Internal medicine, Heart failure with preserved ejection fraction, Cohort, Intensive care unit, Ejection fractionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4385337038 |
|---|---|
| doi | https://doi.org/10.1016/j.ejim.2023.07.027 |
| ids.doi | https://doi.org/10.1016/j.ejim.2023.07.027 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37517939 |
| ids.openalex | https://openalex.org/W4385337038 |
| fwci | 1.00715064 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D013318 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Stroke Volume |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D011379 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Prognosis |
| mesh[3].qualifier_ui | Q000628 |
| mesh[3].descriptor_ui | D006333 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | therapy |
| mesh[3].descriptor_name | Heart Failure |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D006801 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Humans |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D013318 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Stroke Volume |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D011379 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Prognosis |
| mesh[7].qualifier_ui | Q000628 |
| mesh[7].descriptor_ui | D006333 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | therapy |
| mesh[7].descriptor_name | Heart Failure |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D013318 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Stroke Volume |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D011379 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Prognosis |
| mesh[11].qualifier_ui | Q000628 |
| mesh[11].descriptor_ui | D006333 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | therapy |
| mesh[11].descriptor_name | Heart Failure |
| type | article |
| title | Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort |
| biblio.issue | |
| biblio.volume | 118 |
| biblio.last_page | 81 |
| biblio.first_page | 73 |
| grants[0].funder | https://openalex.org/F4320326239 |
| grants[0].award_id | |
| grants[0].funder_display_name | Medizinische Universität Graz |
| grants[1].funder | https://openalex.org/F4320329166 |
| grants[1].award_id | |
| grants[1].funder_display_name | Österreichische Kardiologische Gesellschaft |
| topics[0].id | https://openalex.org/T10198 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2705 |
| topics[0].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[0].display_name | Heart Failure Treatment and Management |
| topics[1].id | https://openalex.org/T10821 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9951000213623047 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2705 |
| topics[1].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[1].display_name | Cardiovascular Function and Risk Factors |
| topics[2].id | https://openalex.org/T12598 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9814000129699707 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Cardiac Structural Anomalies and Repair |
| funders[0].id | https://openalex.org/F4320326239 |
| funders[0].ror | https://ror.org/02n0bts35 |
| funders[0].display_name | Medizinische Universität Graz |
| funders[1].id | https://openalex.org/F4320329166 |
| funders[1].ror | https://ror.org/04g8ype42 |
| funders[1].display_name | Österreichische Kardiologische Gesellschaft |
| is_xpac | False |
| apc_list.value | 3520 |
| apc_list.currency | USD |
| apc_list.value_usd | 3520 |
| apc_paid.value | 3520 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3520 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9697359800338745 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2778198053 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7378910779953003 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q181754 |
| concepts[1].display_name | Heart failure |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6519776582717896 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C2777099384 |
| concepts[3].level | 4 |
| concepts[3].score | 0.5530958771705627 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3799239 |
| concepts[3].display_name | Heart failure with preserved ejection fraction |
| concepts[4].id | https://openalex.org/C72563966 |
| concepts[4].level | 2 |
| concepts[4].score | 0.49452468752861023 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1303415 |
| concepts[4].display_name | Cohort |
| concepts[5].id | https://openalex.org/C2776376669 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4511040449142456 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q5094647 |
| concepts[5].display_name | Intensive care unit |
| concepts[6].id | https://openalex.org/C78085059 |
| concepts[6].level | 3 |
| concepts[6].score | 0.400229811668396 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q641303 |
| concepts[6].display_name | Ejection fraction |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9697359800338745 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/heart-failure |
| keywords[1].score | 0.7378910779953003 |
| keywords[1].display_name | Heart failure |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.6519776582717896 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction |
| keywords[3].score | 0.5530958771705627 |
| keywords[3].display_name | Heart failure with preserved ejection fraction |
| keywords[4].id | https://openalex.org/keywords/cohort |
| keywords[4].score | 0.49452468752861023 |
| keywords[4].display_name | Cohort |
| keywords[5].id | https://openalex.org/keywords/intensive-care-unit |
| keywords[5].score | 0.4511040449142456 |
| keywords[5].display_name | Intensive care unit |
| keywords[6].id | https://openalex.org/keywords/ejection-fraction |
| keywords[6].score | 0.400229811668396 |
| keywords[6].display_name | Ejection fraction |
| language | en |
| locations[0].id | doi:10.1016/j.ejim.2023.07.027 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S138083468 |
| locations[0].source.issn | 0953-6205, 1879-0828 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0953-6205 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | European Journal of Internal Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://www.ejinme.com/article/S0953620523002583/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | European Journal of Internal Medicine |
| locations[0].landing_page_url | https://doi.org/10.1016/j.ejim.2023.07.027 |
| locations[1].id | pmid:37517939 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | European journal of internal medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37517939 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5092558856 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8569-3683 |
| authorships[0].author.display_name | Viktoria Santner |
| authorships[0].countries | AT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[0].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[0].institutions[0].id | https://openalex.org/I202276237 |
| authorships[0].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[0].institutions[0].country_code | AT |
| authorships[0].institutions[0].display_name | Medical University of Graz |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Viktoria Santner |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[1].author.id | https://openalex.org/A5109689300 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Hermann Riepl |
| authorships[1].countries | AT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[1].institutions[0].id | https://openalex.org/I202276237 |
| authorships[1].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[1].institutions[0].country_code | AT |
| authorships[1].institutions[0].display_name | Medical University of Graz |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hermann S. Riepl |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[2].author.id | https://openalex.org/A5005593510 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0448-6314 |
| authorships[2].author.display_name | Florian Posch |
| authorships[2].countries | AT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[2].institutions[0].id | https://openalex.org/I202276237 |
| authorships[2].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[2].institutions[0].country_code | AT |
| authorships[2].institutions[0].display_name | Medical University of Graz |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Florian Posch |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[3].author.id | https://openalex.org/A5066352672 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7692-892X |
| authorships[3].author.display_name | Markus Wallner |
| authorships[3].countries | AT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[3].institutions[0].id | https://openalex.org/I202276237 |
| authorships[3].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[3].institutions[0].country_code | AT |
| authorships[3].institutions[0].display_name | Medical University of Graz |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Markus Wallner |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[4].author.id | https://openalex.org/A5031315514 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2840-6454 |
| authorships[4].author.display_name | Peter P. Rainer |
| authorships[4].countries | AT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Medicine, St. Johann in Tirol General Hospital, St. Johann in Tirol, Austria |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I4210117258 |
| authorships[4].affiliations[2].raw_affiliation_string | BioTechMed Graz, Graz, Austria |
| authorships[4].institutions[0].id | https://openalex.org/I4210117258 |
| authorships[4].institutions[0].ror | https://ror.org/02jfbm483 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210117258 |
| authorships[4].institutions[0].country_code | AT |
| authorships[4].institutions[0].display_name | BioTechMed-Graz |
| authorships[4].institutions[1].id | https://openalex.org/I202276237 |
| authorships[4].institutions[1].ror | https://ror.org/02n0bts35 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I202276237 |
| authorships[4].institutions[1].country_code | AT |
| authorships[4].institutions[1].display_name | Medical University of Graz |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Peter P. Rainer |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | BioTechMed Graz, Graz, Austria, Department of Medicine, St. Johann in Tirol General Hospital, St. Johann in Tirol, Austria, Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[5].author.id | https://openalex.org/A5020152746 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Klemens Ablasser |
| authorships[5].countries | AT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[5].institutions[0].id | https://openalex.org/I202276237 |
| authorships[5].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[5].institutions[0].country_code | AT |
| authorships[5].institutions[0].display_name | Medical University of Graz |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Klemens Ablasser |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[6].author.id | https://openalex.org/A5003796858 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9349-8068 |
| authorships[6].author.display_name | Ewald Kolesnik |
| authorships[6].countries | AT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[6].institutions[0].id | https://openalex.org/I202276237 |
| authorships[6].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[6].institutions[0].country_code | AT |
| authorships[6].institutions[0].display_name | Medical University of Graz |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ewald Kolesnik |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[7].author.id | https://openalex.org/A5111101431 |
| authorships[7].author.orcid | https://orcid.org/0009-0001-7024-2131 |
| authorships[7].author.display_name | Viktoria Hoeller |
| authorships[7].countries | AT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[7].institutions[0].id | https://openalex.org/I202276237 |
| authorships[7].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[7].institutions[0].country_code | AT |
| authorships[7].institutions[0].display_name | Medical University of Graz |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Viktoria Hoeller |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[8].author.id | https://openalex.org/A5034452241 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-0815-6731 |
| authorships[8].author.display_name | David Zach |
| authorships[8].countries | AT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[8].institutions[0].id | https://openalex.org/I202276237 |
| authorships[8].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[8].institutions[0].country_code | AT |
| authorships[8].institutions[0].display_name | Medical University of Graz |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | David Zach |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[9].author.id | https://openalex.org/A5080629113 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-8736-9625 |
| authorships[9].author.display_name | Nora Schwegel |
| authorships[9].countries | AT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[9].institutions[0].id | https://openalex.org/I202276237 |
| authorships[9].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[9].institutions[0].country_code | AT |
| authorships[9].institutions[0].display_name | Medical University of Graz |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nora Schwegel |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[10].author.id | https://openalex.org/A5013624354 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Philipp Kreuzer |
| authorships[10].countries | AT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[10].affiliations[0].raw_affiliation_string | Emergency Medicine Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[10].institutions[0].id | https://openalex.org/I202276237 |
| authorships[10].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[10].institutions[0].country_code | AT |
| authorships[10].institutions[0].display_name | Medical University of Graz |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Philipp Kreuzer |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Emergency Medicine Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[11].author.id | https://openalex.org/A5111535551 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Andreas Lueger |
| authorships[11].countries | AT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[11].affiliations[0].raw_affiliation_string | Emergency Medicine Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[11].institutions[0].id | https://openalex.org/I202276237 |
| authorships[11].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[11].institutions[0].country_code | AT |
| authorships[11].institutions[0].display_name | Medical University of Graz |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Andreas Lueger |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Emergency Medicine Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[12].author.id | https://openalex.org/A5006510755 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-3116-9450 |
| authorships[12].author.display_name | Johannes Petutschnigg |
| authorships[12].countries | DE |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210127591 |
| authorships[12].affiliations[1].raw_affiliation_string | German Center for Cardiovascular Research, Partner Site Berlin, Germany |
| authorships[12].institutions[0].id | https://openalex.org/I7877124 |
| authorships[12].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[12].institutions[0].country_code | DE |
| authorships[12].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[12].institutions[1].id | https://openalex.org/I4210127591 |
| authorships[12].institutions[1].ror | https://ror.org/031t5w623 |
| authorships[12].institutions[1].type | facility |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[12].institutions[1].country_code | DE |
| authorships[12].institutions[1].display_name | German Centre for Cardiovascular Research |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Johannes Petutschnigg |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany, German Center for Cardiovascular Research, Partner Site Berlin, Germany |
| authorships[13].author.id | https://openalex.org/A5009905903 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-6466-5306 |
| authorships[13].author.display_name | Burkert Pieske |
| authorships[13].affiliations[0].raw_affiliation_string | Bachstelzenweg 27, Berlin, Germany |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Burkert Pieske |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Bachstelzenweg 27, Berlin, Germany |
| authorships[14].author.id | https://openalex.org/A5021427999 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-6290-3297 |
| authorships[14].author.display_name | Andreas Zirlik |
| authorships[14].countries | AT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[14].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[14].institutions[0].id | https://openalex.org/I202276237 |
| authorships[14].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[14].institutions[0].country_code | AT |
| authorships[14].institutions[0].display_name | Medical University of Graz |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Andreas Zirlik |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[15].author.id | https://openalex.org/A5008989410 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-4401-5936 |
| authorships[15].author.display_name | Frank Edelmann |
| authorships[15].countries | DE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I7877124 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I4210127591 |
| authorships[15].affiliations[1].raw_affiliation_string | German Center for Cardiovascular Research, Partner Site Berlin, Germany |
| authorships[15].institutions[0].id | https://openalex.org/I7877124 |
| authorships[15].institutions[0].ror | https://ror.org/001w7jn25 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I7877124 |
| authorships[15].institutions[0].country_code | DE |
| authorships[15].institutions[0].display_name | Charité - Universitätsmedizin Berlin |
| authorships[15].institutions[1].id | https://openalex.org/I4210127591 |
| authorships[15].institutions[1].ror | https://ror.org/031t5w623 |
| authorships[15].institutions[1].type | facility |
| authorships[15].institutions[1].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[15].institutions[1].country_code | DE |
| authorships[15].institutions[1].display_name | German Centre for Cardiovascular Research |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Frank Edelmann |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany, German Center for Cardiovascular Research, Partner Site Berlin, Germany |
| authorships[16].author.id | https://openalex.org/A5051718614 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-7414-4056 |
| authorships[16].author.display_name | Nicolas Verheyen |
| authorships[16].countries | AT |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I202276237 |
| authorships[16].affiliations[0].raw_affiliation_string | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| authorships[16].institutions[0].id | https://openalex.org/I202276237 |
| authorships[16].institutions[0].ror | https://ror.org/02n0bts35 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I202276237 |
| authorships[16].institutions[0].country_code | AT |
| authorships[16].institutions[0].display_name | Medical University of Graz |
| authorships[16].author_position | last |
| authorships[16].raw_author_name | Nicolas Verheyen |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | Division of Cardiology, University Heart Center and Department of Internal Medicine, Medical University of Graz, Graz, Austria |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.ejinme.com/article/S0953620523002583/pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10198 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2705 |
| primary_topic.subfield.display_name | Cardiology and Cardiovascular Medicine |
| primary_topic.display_name | Heart Failure Treatment and Management |
| related_works | https://openalex.org/W2011390101, https://openalex.org/W4385397996, https://openalex.org/W4207030337, https://openalex.org/W2891746874, https://openalex.org/W2481234813, https://openalex.org/W1971710084, https://openalex.org/W2072108749, https://openalex.org/W4390348475, https://openalex.org/W2028196543, https://openalex.org/W4376630782 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.ejim.2023.07.027 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S138083468 |
| best_oa_location.source.issn | 0953-6205, 1879-0828 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0953-6205 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | European Journal of Internal Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://www.ejinme.com/article/S0953620523002583/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | European Journal of Internal Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.ejim.2023.07.027 |
| primary_location.id | doi:10.1016/j.ejim.2023.07.027 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S138083468 |
| primary_location.source.issn | 0953-6205, 1879-0828 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0953-6205 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | European Journal of Internal Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://www.ejinme.com/article/S0953620523002583/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | European Journal of Internal Medicine |
| primary_location.landing_page_url | https://doi.org/10.1016/j.ejim.2023.07.027 |
| publication_date | 2023-07-28 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2120934972, https://openalex.org/W4206772894, https://openalex.org/W3213765074, https://openalex.org/W2897297729, https://openalex.org/W3193297191, https://openalex.org/W2068519950, https://openalex.org/W2152072062, https://openalex.org/W2971294569, https://openalex.org/W2127254785, https://openalex.org/W4293354639, https://openalex.org/W2187526770, https://openalex.org/W2989425857, https://openalex.org/W1980889365, https://openalex.org/W2013432740, https://openalex.org/W2571483332, https://openalex.org/W3215047743, https://openalex.org/W2607139442, https://openalex.org/W3102892696, https://openalex.org/W2980734809, https://openalex.org/W4210520398, https://openalex.org/W2397911846, https://openalex.org/W2891975710, https://openalex.org/W2548855492, https://openalex.org/W3095924820, https://openalex.org/W2617287176, https://openalex.org/W6782293990, https://openalex.org/W2916315813, https://openalex.org/W2074912926, https://openalex.org/W2842271423, https://openalex.org/W3172661370, https://openalex.org/W3081482425, https://openalex.org/W2427094903 |
| referenced_works_count | 32 |
| abstract_inverted_index.= | 169, 179, 189, 200 |
| abstract_inverted_index.a | 50, 121, 224 |
| abstract_inverted_index.p | 168, 178, 188, 199 |
| abstract_inverted_index.We | 24 |
| abstract_inverted_index.an | 34, 254 |
| abstract_inverted_index.at | 18, 239 |
| abstract_inverted_index.by | 88 |
| abstract_inverted_index.in | 33, 129, 223, 246 |
| abstract_inverted_index.of | 21, 93, 124 |
| abstract_inverted_index.to | 26, 49 |
| abstract_inverted_index.we | 65 |
| abstract_inverted_index.1.9 | 125 |
| abstract_inverted_index.121 | 130 |
| abstract_inverted_index.28% | 110 |
| abstract_inverted_index.35% | 107 |
| abstract_inverted_index.40% | 104 |
| abstract_inverted_index.407 | 67 |
| abstract_inverted_index.49% | 117 |
| abstract_inverted_index.51% | 113 |
| abstract_inverted_index.53% | 143 |
| abstract_inverted_index.62% | 153 |
| abstract_inverted_index.64% | 181 |
| abstract_inverted_index.65% | 192 |
| abstract_inverted_index.67% | 161 |
| abstract_inverted_index.68% | 171 |
| abstract_inverted_index.76% | 145 |
| abstract_inverted_index.80% | 194 |
| abstract_inverted_index.81% | 183 |
| abstract_inverted_index.84% | 163 |
| abstract_inverted_index.85% | 173 |
| abstract_inverted_index.87% | 155 |
| abstract_inverted_index.88% | 101 |
| abstract_inverted_index.95% | 149 |
| abstract_inverted_index.<20 | 209 |
| abstract_inverted_index.CI: | 150 |
| abstract_inverted_index.The | 91 |
| abstract_inverted_index.and | 9, 39, 62, 72, 84, 116, 139, 191, 217, 250 |
| abstract_inverted_index.any | 57 |
| abstract_inverted_index.for | 29, 56, 76, 102, 105, 108, 111, 114, 118, 137, 146, 156, 164, 174, 184, 195, 229, 233 |
| abstract_inverted_index.its | 40 |
| abstract_inverted_index.may | 14 |
| abstract_inverted_index.vs. | 144, 154, 162, 172, 182, 193 |
| abstract_inverted_index.2018 | 61 |
| abstract_inverted_index.COPD | 212 |
| abstract_inverted_index.July | 63 |
| abstract_inverted_index.care | 52 |
| abstract_inverted_index.eGFR | 208 |
| abstract_inverted_index.have | 15 |
| abstract_inverted_index.home | 214 |
| abstract_inverted_index.poor | 22 |
| abstract_inverted_index.risk | 20, 242 |
| abstract_inverted_index.unit | 55 |
| abstract_inverted_index.were | 86, 100, 142, 207, 243 |
| abstract_inverted_index.with | 6, 42, 69, 213 |
| abstract_inverted_index.2019, | 64 |
| abstract_inverted_index.Among | 45 |
| abstract_inverted_index.HFpEF | 71 |
| abstract_inverted_index.aimed | 25 |
| abstract_inverted_index.cases | 131 |
| abstract_inverted_index.chart | 89 |
| abstract_inverted_index.death | 206 |
| abstract_inverted_index.heart | 4, 36, 220 |
| abstract_inverted_index.need. | 257 |
| abstract_inverted_index.their | 251 |
| abstract_inverted_index.trial | 97 |
| abstract_inverted_index.unmet | 255 |
| abstract_inverted_index.(30%). | 132 |
| abstract_inverted_index.32.028 | 46 |
| abstract_inverted_index.August | 60 |
| abstract_inverted_index.During | 120 |
| abstract_inverted_index.TOPCAT | 165 |
| abstract_inverted_index.assess | 27 |
| abstract_inverted_index.center | 53 |
| abstract_inverted_index.cohort | 38 |
| abstract_inverted_index.likely | 244 |
| abstract_inverted_index.median | 122 |
| abstract_inverted_index.oxygen | 215 |
| abstract_inverted_index.reason | 58 |
| abstract_inverted_index.severe | 218 |
| abstract_inverted_index.trials | 2, 32, 78, 231, 249 |
| abstract_inverted_index.years, | 126 |
| abstract_inverted_index.(HFpEF) | 8 |
| abstract_inverted_index.0.002), | 170, 190 |
| abstract_inverted_index.0.003), | 180 |
| abstract_inverted_index.0.010). | 201 |
| abstract_inverted_index.DELIVER | 85, 196 |
| abstract_inverted_index.HFmrEF. | 73 |
| abstract_inverted_index.Pivotal | 0 |
| abstract_inverted_index.TOPCAT, | 81, 109 |
| abstract_inverted_index.between | 59 |
| abstract_inverted_index.cohort, | 227 |
| abstract_inverted_index.evident | 70 |
| abstract_inverted_index.failure | 5, 37 |
| abstract_inverted_index.highest | 19, 240 |
| abstract_inverted_index.medical | 256 |
| abstract_inverted_index.outcome | 1, 31, 230, 248 |
| abstract_inverted_index.overall | 134 |
| abstract_inverted_index.pivotal | 77 |
| abstract_inverted_index.remains | 253 |
| abstract_inverted_index.review. | 90 |
| abstract_inverted_index.(HFmrEF) | 13 |
| abstract_inverted_index.DELIVER. | 119 |
| abstract_inverted_index.assessed | 87 |
| abstract_inverted_index.criteria | 75, 99, 203 |
| abstract_inverted_index.disease. | 221 |
| abstract_inverted_index.ejection | 11 |
| abstract_inverted_index.eligible | 140 |
| abstract_inverted_index.excluded | 16 |
| abstract_inverted_index.fraction | 12 |
| abstract_inverted_index.occurred | 128 |
| abstract_inverted_index.patients | 17, 47, 238 |
| abstract_inverted_index.previous | 247 |
| abstract_inverted_index.strongly | 234 |
| abstract_inverted_index.survival | 135 |
| abstract_inverted_index.tertiary | 51 |
| abstract_inverted_index.therapy, | 216 |
| abstract_inverted_index.valvular | 219 |
| abstract_inverted_index.(HR=1.71, | 197 |
| abstract_inverted_index.(HR=1.90, | 186 |
| abstract_inverted_index.(HR=2.04, | 166 |
| abstract_inverted_index.(HR=2.28, | 176 |
| abstract_inverted_index.(HR=2.32, | 148 |
| abstract_inverted_index.(HR=2.97, | 158 |
| abstract_inverted_index.Exclusion | 202 |
| abstract_inverted_index.PARAGONHF | 175 |
| abstract_inverted_index.all-cause | 43 |
| abstract_inverted_index.emergency | 54 |
| abstract_inverted_index.estimates | 136 |
| abstract_inverted_index.follow-up | 123 |
| abstract_inverted_index.increased | 235 |
| abstract_inverted_index.mortality | 241 |
| abstract_inverted_index.outcomes. | 23 |
| abstract_inverted_index.p<0.001), | 152, 160 |
| abstract_inverted_index.predicted | 232 |
| abstract_inverted_index.preserved | 7 |
| abstract_inverted_index.targeting | 3 |
| abstract_inverted_index.treatment | 252 |
| abstract_inverted_index.1.14-2.57, | 198 |
| abstract_inverted_index.1.27-2.84, | 187 |
| abstract_inverted_index.1.29-3.24, | 167 |
| abstract_inverted_index.1.33-3.90, | 177 |
| abstract_inverted_index.1.47-3.67, | 151 |
| abstract_inverted_index.1.85-4.77, | 159 |
| abstract_inverted_index.I-PRESERVE | 157 |
| abstract_inverted_index.admissions | 68, 94, 141 |
| abstract_inverted_index.fulfilling | 95 |
| abstract_inverted_index.identified | 66 |
| abstract_inverted_index.mortality. | 44, 236 |
| abstract_inverted_index.predicting | 205 |
| abstract_inverted_index.presenting | 48 |
| abstract_inverted_index.unselected | 35 |
| abstract_inverted_index.Eligibility | 74 |
| abstract_inverted_index.I-PRESERVE, | 80, 106 |
| abstract_inverted_index.PARAGON-HF, | 82, 112 |
| abstract_inverted_index.association | 41 |
| abstract_inverted_index.eligibility | 28, 98 |
| abstract_inverted_index.ml/min/1.73 | 210 |
| abstract_inverted_index.proportions | 92 |
| abstract_inverted_index.HFpEF/HFmrEF | 30, 96, 226, 237 |
| abstract_inverted_index.contemporary | 225 |
| abstract_inverted_index.non-eligible | 138 |
| abstract_inverted_index.Conclusively, | 222 |
| abstract_inverted_index.independently | 204 |
| abstract_inverted_index.m<sup>2</sup>, | 211 |
| abstract_inverted_index.mildly-reduced | 10 |
| abstract_inverted_index.CHARM-Preserved | 147 |
| abstract_inverted_index.non-eligibility | 228 |
| abstract_inverted_index.CHARM-Preserved, | 79, 103 |
| abstract_inverted_index.underrepresented | 245 |
| abstract_inverted_index.EMPEROR-Preserved | 83, 185 |
| abstract_inverted_index.Twenty-four-month | 133 |
| abstract_inverted_index.EMPEROR-Preserved, | 115 |
| abstract_inverted_index.death-from-any-cause | 127 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5051718614 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 17 |
| corresponding_institution_ids | https://openalex.org/I202276237 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.74549438 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |