Non-invasive tests for fibrotic MASH for reducing screen failure in therapeutic trials Article Swipe
Jeanne Fichez
,
Thomas Mouillot
,
Luisa Vonghia
,
Charlotte Costentin
,
C Moreau
,
Marine Roux
,
Adèle Delamarre
,
Sven Francque
,
Ming‐Hua Zheng
,
Jérôme Boursier
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jhepr.2025.101351
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jhepr.2025.101351
Drug development in metabolic dysfunction-associated steatohepatitis (MASH) is hampered by a high screen failure rate, one of the main reasons being the absence of MASH and significant fibrosis (fibrotic MASH) on the baseline liver biopsy, a key inclusion criterion in MASH therapeutic trials. Non-invasive tests represent an attractive opportunity to better select candidates for these trials, but most of them have been developed for advanced fibrosis and the new tests designed for the diagnosis of fibrotic MASH remain poorly validated. In this work, we demonstrate that the tests specifically designed for fibrotic MASH are more accurate for this diagnostic target than the tests currently recommended and initially developed for advanced fibrosis. We propose sequential combinations that will facilitate the identification of patients with fibrotic MASH in need of treatment, and their inclusion in MASH therapeutic trials.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jhepr.2025.101351
- OA Status
- gold
- Cited By
- 4
- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://doi.org/10.1016/j.jhepr.2025.101351Digital Object Identifier
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Non-invasive tests for fibrotic MASH for reducing screen failure in therapeutic trialsWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-02-04Full publication date if available
- Authors
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Jeanne Fichez, Thomas Mouillot, Luisa Vonghia, Charlotte Costentin, C Moreau, Marine Roux, Adèle Delamarre, Sven Francque, Ming‐Hua Zheng, Jérôme BoursierList of authors in order
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https://doi.org/10.1016/j.jhepr.2025.101351Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.jhepr.2025.101351Direct OA link when available
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Medicine, Intensive care medicineTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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