Non‑alcoholic fatty liver disease: A major challenge in type�2 diabetes mellitus (Review) Article Swipe
Cristina Bică
,
Camelia Sandu
,
Andra‐Iulia Suceveanu
,
Eliza Sarbu
,
Roxana Adriana Stoica
,
Florentina Gherghiceanu
,
Roxana Elena Bohîlţea
,
Simona Ștefan
,
Anca Pantea Stoian
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/etm.2020.8882
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/etm.2020.8882
Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in type 2 diabetes mellitus (T2DM) patients, being one of the disorders with a relevant global burden. Cross-sectional studies have shown that patients with T2DM and NAFLD have a higher prevalence of liver fibrosis, compared with the general population. Patients with non-alcoholic steatohepatitis (NASH) and T2DM have an increased mortality and morbidity, therefore they generate substantial health care costs. NASH worsens chronic diabetes complications, and T2DM aggravate the NASH progression to fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). The objectives in NAFLD and NASH therapy are to reduce disease activity, to slow down progression of fibrosis, and to lower the risk factors. Unfortunately, there are no specific validated pharmacological therapies. Several trials have demonstrated that anti-diabetic agents such as thiazolidindiones, sodium-glucose co-transporter inhibitors, glucagon like peptide-1 receptor analogs, or dipeptidyl peptidase-4 inhibitors might have complimentary benefits for patients with NAFLD. Some of the effect on reducing steatosis and fibrosis is explained by the weight loss these treatments produce. A goal in standard care is developing screening tools, early and non-invasive diagnosis methods, studying the pleiotropic effects of drugs, together with newer therapeutic agents, which can target mutual pathogenic mechanisms for diabetes and liver disease.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3892/etm.2020.8882
- http://www.spandidos-publications.com/10.3892/etm.2020.8882/download
- OA Status
- diamond
- Cited By
- 15
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3034967575
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3034967575Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3892/etm.2020.8882Digital Object Identifier
- Title
-
Non‑alcoholic fatty liver disease: A major challenge in type�2 diabetes mellitus (Review)Work title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-06-12Full publication date if available
- Authors
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Cristina Bică, Camelia Sandu, Andra‐Iulia Suceveanu, Eliza Sarbu, Roxana Adriana Stoica, Florentina Gherghiceanu, Roxana Elena Bohîlţea, Simona Ștefan, Anca Pantea StoianList of authors in order
- Landing page
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https://doi.org/10.3892/etm.2020.8882Publisher landing page
- PDF URL
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https://www.spandidos-publications.com/10.3892/etm.2020.8882/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://www.spandidos-publications.com/10.3892/etm.2020.8882/downloadDirect OA link when available
- Concepts
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Fatty liver, Type 2 Diabetes Mellitus, Molecular medicine, Diabetes mellitus, Disease, Alcoholic liver disease, Oncogene, Cell cycle, Medicine, Type 2 diabetes, Internal medicine, Cancer, Endocrinology, CirrhosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 1, 2023: 5, 2022: 4, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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