Noninvasive and remote measurement of sleep‐active glymphatic function in the human brain by dynamic impedance spectro‐tomography Article Swipe
Jeffrey J. Iliff
,
Swati Rane Levendovszky
,
Carla Vanderweerd
,
Michael Jaffe
,
Jeffrey Lowenkron
,
Tarandeep Singh
,
Laurent Giovangrandi
,
Miranda M. Lim
,
Paul Dagum
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.083160
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.083160
Background Perivascular glymphatic exchange contributes to the clearance of amyloid β, tau, and α synuclein primarily during sleep. Glymphatic function has been assessed in human populations solely through neuroimaging, including contrast‐enhanced magnetic resonance imaging (CE‐MRI). Using a newly developed investigational medical device (IMD) to measure brain parenchymal resistance to fluid flow by dynamic impedance spectro‐tomography, we evaluated the performance of this putative measure of glymphatic function against “gold‐standard” CE‐MRI. Method Healthy 55‐65 y/o participants were enrolled in a cross‐over randomized control clinical trial encompassing one night of sleep/sleep deprivation followed by 4hr morning window of wake/sleep. Intravenous CE‐MRI was obtained prior to (T0) and following (T1) the 4hr window. Participants were instrumented with the IMD to measure continuous changes in brain parenchymal resistance (R). For the ROIs of interest, contrast enhancement (CE) was measured as the ratio of the T1/T0 MRI signal. The ratio CE p /CE d of anatomically proximal ROIs (CE p ) to distal ROIs (CE d ) was used to measure increasing (CE p /CE d ≤ 1) or decreasing (CE p /CE d > 1) net contrast movement. The predictive value of the R measured by the IMD, multiple EEG powerbands, and time spent in N2, N3 and REM sleep were tested against the CE‐MRI ROI ratios. Data from fourteen intervention periods were available for analysis. Result IMD parenchymal resistance R predicted IV CE‐MRI contrast movement through blood, cerebrospinal fluid, and interstitial brain compartments (Table 1, Figure 1). EEG slow power predicted contrast movement into more proximal ROIs only. Other powerbands and hypnogram sleep stages were not predictive of contrast movement. Conclusion EEG powerbands (increased slow, reduced beta) were weakly associated with increased glymphatic exchange measured by CE‐MRI. Parenchymal resistance R measured by the IMD were robust predictors of contrast movement from proximal (ventricles, subarachnoid) CSF compartments, through parenchymal compartments (gray matter, white matter). These findings begin to validate IMD‐derived parenchymal R as non‐imaging measure of glymphatic function. Detection of glymphatic impairment in real‐world settings may permit (i) early identification of individuals at‐risk for developing sleep‐related Alzheimer’s disease pathology, and (ii) enable precision targeted enhancement of glymphatic function to enhance glymphatic function and pathological protein clearance.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.083160
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083160
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390191919
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390191919Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/alz.083160Digital Object Identifier
- Title
-
Noninvasive and remote measurement of sleep‐active glymphatic function in the human brain by dynamic impedance spectro‐tomographyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-01Full publication date if available
- Authors
-
Jeffrey J. Iliff, Swati Rane Levendovszky, Carla Vanderweerd, Michael Jaffe, Jeffrey Lowenkron, Tarandeep Singh, Laurent Giovangrandi, Miranda M. Lim, Paul DagumList of authors in order
- Landing page
-
https://doi.org/10.1002/alz.083160Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083160Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083160Direct OA link when available
- Concepts
-
Glymphatic system, Magnetic resonance imaging, Medicine, Cerebrospinal fluid, Nuclear medicine, Neuroimaging, Pathology, Radiology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S108427512 |
| primary_location.source.issn | 1552-5260, 1552-5279 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1552-5260 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Alzheimer s & Dementia |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.083160 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Alzheimer's & Dementia |
| primary_location.landing_page_url | https://doi.org/10.1002/alz.083160 |
| publication_date | 2023-12-01 |
| publication_year | 2023 |
| referenced_works_count | 0 |
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