Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency Ultrasound Article Swipe
Eric M. Strohm
,
Neal I. Callaghan
,
Yu Ding
,
Neda Latifi
,
Naimeh Rafatian
,
Shunsuke Funakoshi
,
Ian Fernandes
,
Cristine J. Reitz
,
Michelle Di Paola
,
Anthony O. Gramolini
,
Milica Radisic
,
Gordon Keller
,
Michael C. Kolios
,
Craig A. Simmons
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.3c06325
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.3c06325
Cell-based models that mimic in vivo heart physiology are poised to make significant advances in cardiac disease modeling and drug discovery. In these systems, cardiomyocyte (CM) contractility is an important functional metric, but current measurement methods are inaccurate and low-throughput or require complex setups. To address this need, we developed a standalone noninvasive, label-free ultrasound technique operating at 40-200 MHz to measure the contractile kinetics of cardiac models, ranging from single adult CMs to 3D microtissue constructs in standard cell culture formats. The high temporal resolution of 1000 fps resolved the beat profile of single mouse CMs paced at up to 9 Hz, revealing limitations of lower speed optical based measurements to resolve beat kinetics or characterize aberrant beats. Coupling of ultrasound with traction force microscopy enabled the measurement of the CM longitudinal modulus and facile estimation of adult mouse CM contractile forces of 2.34 ± 1.40 μN, comparable to more complex measurement techniques. Similarly, the beat rate, rhythm, and drug responses of CM spheroid and microtissue models were measured, including in configurations without optical access. In conclusion, ultrasound can be used for the rapid characterization of CM contractile function in a wide range of commonly studied configurations ranging from single cells to 3D tissue constructs using standard well plates and custom microdevices, with applications in cardiac drug discovery and cardiotoxicity evaluation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.3c06325
- OA Status
- green
- Cited By
- 6
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390222451
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390222451Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsnano.3c06325Digital Object Identifier
- Title
-
Noninvasive Quantification of Contractile Dynamics in Cardiac Cells, Spheroids, and Organs-on-a-Chip Using High-Frequency UltrasoundWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-26Full publication date if available
- Authors
-
Eric M. Strohm, Neal I. Callaghan, Yu Ding, Neda Latifi, Naimeh Rafatian, Shunsuke Funakoshi, Ian Fernandes, Cristine J. Reitz, Michelle Di Paola, Anthony O. Gramolini, Milica Radisic, Gordon Keller, Michael C. Kolios, Craig A. SimmonsList of authors in order
- Landing page
-
https://doi.org/10.1021/acsnano.3c06325Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/12321359Direct OA link when available
- Concepts
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High frequency ultrasound, Spheroid, Ultrasound, Dynamics (music), Materials science, Biomedical engineering, Nanotechnology, Chemistry, Medicine, Radiology, Physics, Acoustics, In vitro, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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68Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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