Nonlinear analysis of beat-to-beat variability of action potential time series data identifies dynamic re-entrant substrates in a hypokalaemic mouse model of acquired long QT syndrome Article Swipe

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Gary Tse , Jiandong Zhou , Xiuming Dong , Guoliang Hao , Sharen Lee , Keith Sai Kit Leung , Fung Ping Leung , Tong Liu , Yimei Du , Shuk Han Cheng , Wing Tak Wong ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1186/s42444-023-00084-4

Background \nPrevious studies have quantified repolarization variability using time-domain, frequency-domain and nonlinear analysis in mouse hearts. Here, we investigated the relationship between these parameters and ventricular arrhythmogenicity in a hypokalaemia model of acquired long QT syndrome. \n \nMethods \nLeft ventricular monophasic action potentials (MAPs) were recorded during right ventricular regular 8 Hz pacing during normokalaemia (5.2 mM [K+]), hypokalaemia modeling LQTS (3 mM [K+]) or hypokalaemia with 0.1 mM heptanol in Langendorff-perfused mouse hearts. \n \nResults \nDuring normokalaemia, mean APD was 33.5 ± 3.7 ms. Standard deviation (SD) of APDs was 0.63 ± 0.33 ms, coefficient of variation was 1.9 ± 1.0% and the root mean square (RMS) of successive differences in APDs was 0.3 ± 0.1 ms. Low- and high-frequency peaks were 0.6 ± 0.5 and 2.3 ± 0.7 Hz, respectively, with percentage powers of 38 ± 22 and 61 ± 23%. Poincaré plots of APDn+1 against APDn revealed ellipsoid morphologies with SD along the line-of-identity (SD2) to SD perpendicular to the line-of-identity (SD1) ratio of 4.6 ± 1.1. Approximate and sample entropy were 0.49 ± 0.12 and 0.64 ± 0.29, respectively. Detrended fluctuation analysis revealed short- and long-term fluctuation slopes of 1.62 ± 0.27 and 0.60 ± 0.18, respectively. Hypokalaemia provoked ventricular tachycardia in six of seven hearts, prolonged APDs (51.2 ± 7.9 ms), decreased SD2/SD1 ratio (3.1 ± 1.0), increased approximate and sample entropy (0.68 ± 0.08 and 1.02 ± 0.33) and decreased short-term fluctuation slope (1.23 ± 0.20) (ANOVA, P < 0.05). Heptanol prevented VT in all hearts studied without further altering the above repolarization parameters observed during hypokalaemia. \n \nConclusion \nReduced SD2/SD1, increased entropy and decreased short-term fluctuation slope may reflect arrhythmic risk in hypokalaemia. Heptanol exerts anti-arrhythmic effects without affecting repolarization variability.

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Beat (acoustics) Nonlinear system Time series Computer science Speech recognition Physics Acoustics Machine learning Quantum mechanics

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Type: article
Language: en
Landing Page: https://doi.org/10.1186/s42444-023-00084-4
PDF: https://arrhythmia.biomedcentral.com/counter/pdf/10.1186/s42444-023-00084-4
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Cited By: 1
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Title: Nonlinear analysis of beat-to-beat variability of action potential time series data identifies dynamic re-entrant substrates in a hypokalaemic mouse model of acquired long QT syndrome

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Publication year: 2023

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Authors: Gary Tse, Jiandong Zhou, Xiuming Dong, Guoliang Hao, Sharen Lee, Keith Sai Kit Leung, Fung Ping Leung, Tong Liu, Yimei Du, Shuk Han Cheng, Wing Tak Wong

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Concepts: Beat (acoustics), Nonlinear system, Time series, Computer science, Speech recognition, Physics, Acoustics, Machine learning, Quantum mechanics

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