Nonreciprocal synchronization in embryonic oscillator ensembles Article Swipe
Christine Ho
,
Laurent Jutras-Dubé
,
Michael L. Zhao
,
Gregor Mönke
,
István Z. Kiss
,
Paul François
,
Alexander Aulehla
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2401604121
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2401604121
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts, e.g., chemical wave patterns, superconductors, and the unison applause we witness in concert halls. The existence of common underlying coupling rules defines universality classes, revealing a fundamental sameness between seemingly distinct systems. Identifying rules of synchronization in any particular setting is hence of paramount relevance. Here, we address the coupling rules within an embryonic oscillator ensemble linked to vertebrate embryo body axis segmentation. In vertebrates, the periodic segmentation of the body axis involves synchronized signaling oscillations in cells within the presomitic mesoderm (PSM), from which somites, the prevertebrae, form. At the molecular level, it is known that intact Notch-signaling and cell-to-cell contact are required for synchronization between PSM cells. However, an understanding of the coupling rules is still lacking. To identify these, we develop an experimental assay that enables direct quantification of synchronization dynamics within mixtures of oscillating cell ensembles, for which the initial input frequency and phase distribution are known. Our results reveal a “winner-takes-it-all” synchronization outcome, i.e., the emerging collective rhythm matches one of the input rhythms. Using a combination of theory and experimental validation, we develop a coupling model, the “Rectified Kuramoto” (ReKu) model, characterized by a phase-dependent, nonreciprocal interaction in the coupling of oscillatory cells. Such nonreciprocal synchronization rules reveal fundamental similarities between embryonic oscillators and a class of collective behaviors seen in neurons and fireflies, where higher-level computations are performed and linked to nonreciprocal synchronization.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2401604121
- OA Status
- hybrid
- Cited By
- 4
- References
- 46
- Related Works
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- OpenAlex ID
- https://openalex.org/W4401910421
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4401910421Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1073/pnas.2401604121Digital Object Identifier
- Title
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Nonreciprocal synchronization in embryonic oscillator ensemblesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
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2024-08-27Full publication date if available
- Authors
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Christine Ho, Laurent Jutras-Dubé, Michael L. Zhao, Gregor Mönke, István Z. Kiss, Paul François, Alexander AulehlaList of authors in order
- Landing page
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https://doi.org/10.1073/pnas.2401604121Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1073/pnas.2401604121Direct OA link when available
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Synchronization (alternating current), Coupling (piping), Physics, Embryonic stem cell, Computer science, Topology (electrical circuits), Biology, Mathematics, Engineering, Gene, Mechanical engineering, Combinatorics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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