Nontargeted LC–MS Metabolomics Approach for Metabolic Profiling of Plasma and Urine from Pigs Fed Branched Chain Amino Acids for Maximum Growth Performance Article Swipe
Elham Assadi Soumeh
,
Mette Skou Hedemann
,
Hanne Poulsen
,
E. Corrent
,
Jaap J. van Milgen
,
Jan Værum Nørgaard
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jproteome.6b00184
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jproteome.6b00184
The metabolic response in plasma and urine of pigs when feeding an optimum level of branched chain amino acids (BCAAs) for best growth performance is unknown. The objective of the current study was to identify the metabolic phenotype associated with the BCAAs intake level that could be linked to the animal growth performance. Three dose-response studies were carried out to collect blood and urine samples from pigs fed increasing levels of Ile, Val, or Leu followed by a nontargeted LC-MS approach to characterize the metabolic profile of biofluids when dietary BCAAs are optimum for animal growth. Results showed that concentrations of plasma hypoxanthine and tyrosine (Tyr) were higher while concentrations of glycocholic acid, tauroursodeoxycholic acid, and taurocholic acid were lower when the dietary Ile was optimum. Plasma 3-methyl-2-oxovaleric acid and creatine were lower when dietary Leu was optimum. The optimum dietary Leu resulted in increased urinary excretion of ascorbic acid and choline and relatively decreased excretion of 2-aminoadipic acid, acetyl-dl-valine, Ile, 2-methylbutyrylglycine, and Tyr. In conclusion, plasma glycocholic acid and taurocholic acid were discriminating metabolites to the optimum dietary Ile. The optimum dietary Leu was associated with reduced plasma creatine and urinary 2-aminoadipic acid and elevated urinary excretion of ascorbic acid and choline. The optimum dietary Val had a less pronounced metabolic response reflected in plasma or urine than other BCAA.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.jproteome.6b00184
- OA Status
- green
- Cited By
- 19
- References
- 43
- Related Works
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- OpenAlex ID
- https://openalex.org/W2528360257
All OpenAlex metadata
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https://openalex.org/W2528360257Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.jproteome.6b00184Digital Object Identifier
- Title
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Nontargeted LC–MS Metabolomics Approach for Metabolic Profiling of Plasma and Urine from Pigs Fed Branched Chain Amino Acids for Maximum Growth PerformanceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
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2016-10-05Full publication date if available
- Authors
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Elham Assadi Soumeh, Mette Skou Hedemann, Hanne Poulsen, E. Corrent, Jaap J. van Milgen, Jan Værum NørgaardList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.jproteome.6b00184Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://hal.inrae.fr/hal-02633644Direct OA link when available
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Metabolomics, Urine, Chromatography, Chemistry, Amino acid, Metabolic pathway, Metabolism, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 1, 2022: 3, 2021: 5Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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