Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression Article Swipe
Mattia Privitera
,
Lukas von Ziegler
,
Amalia Floriou‐Servou
,
Sian N. Duss
,
Runzhong Zhang
,
Rebecca Waag
,
Sebastian Leimbacher
,
Oliver Sturman
,
Fabienne K. Roessler
,
Annelies Heylen
,
Yannick Vermeiren
,
Debby Van Dam
,
Peter Paul De Deyn
,
Pierre‐Luc Germain
,
Johannes Bohacek
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88559
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88559
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations to isolate the contribution of the locus coeruleus-noradrenaline (LC-NA) system to the acute stress response in mice. We reveal that NA release during stress exposure regulates a large and reproducible set of genes in the dorsal and ventral hippocampus via β-adrenergic receptors. For a smaller subset of these genes, we show that NA release triggered by LC stimulation is sufficient to mimic the stress-induced transcriptional response. We observe these effects in both sexes, and independent of the pattern and frequency of LC activation. Using a retrograde optogenetic approach, we demonstrate that hippocampus-projecting LC neurons directly regulate hippocampal gene expression. Overall, a highly selective set of astrocyte-enriched genes emerges as key targets of LC-NA activation, most prominently several subunits of protein phosphatase 1 ( Ppp1r3c , Ppp1r3d , Ppp1r3g ) and type II iodothyronine deiodinase ( Dio2 ). These results highlight the importance of astrocytic energy metabolism and thyroid hormone signaling in LC-mediated hippocampal function and offer new molecular targets for understanding how NA impacts brain function in health and disease.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.88559
- OA Status
- gold
- Cited By
- 16
- References
- 82
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4385457160
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385457160Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.88559Digital Object Identifier
- Title
-
Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expressionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-01Full publication date if available
- Authors
-
Mattia Privitera, Lukas von Ziegler, Amalia Floriou‐Servou, Sian N. Duss, Runzhong Zhang, Rebecca Waag, Sebastian Leimbacher, Oliver Sturman, Fabienne K. Roessler, Annelies Heylen, Yannick Vermeiren, Debby Van Dam, Peter Paul De Deyn, Pierre‐Luc Germain, Johannes BohacekList of authors in order
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https://doi.org/10.7554/elife.88559Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.88559Direct OA link when available
- Concepts
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Locus coeruleus, Hippocampal formation, Neuroscience, Gene expression, Locus (genetics), Norepinephrine, Biology, Hippocampus, Gene, Cell biology, Genetics, Central nervous system, DopamineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
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2025: 12, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
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82Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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