Normative data on the CERAD Word List in a robustly intact sample of older adults Article Swipe
Kevin Duff
,
Elise J Hanna
,
Nora Mattek
,
Madison DeCapo
,
Nathan Hantke
,
Aimee Pierce
,
Jeffrey Kaye
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.076991
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.076991
Background List learning and memory tests are frequently used to evaluate older adults for late life cognitive disorders, such as Alzheimer’s disease. The Word List subtest of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological battery has been widely‐used in clinical research, including clinical trials, to identify and track such disorders. It is also freely‐available, as it is in the public domain. However, normative data, especially in robustly intact older adults, is lacking. Method CERAD Word List data from 897 older adults (age in years: M = 81.1, SD = 8.1, range 55‐100; 67% women; education in years: M = 14.8, SD = 2.8, range = 7‐24) deemed to be cognitively intact at two annual visits in a longitudinal observational study from the Uniform Data Set of the National Alzheimer’s Coordinating Center were used to generate predicted Word List scores based on age, sex, and education. Predicted scores were compared to observed scores to preliminarily validate these normative values. Result For six primary scores from the Word List subtest (Trial 1, Trial 2, Trial 3, Total Acquisition, Delay Recall, Recognition Total Correct), the three demographic variables significantly predicted test scores, with R 2 s ranging from 0.03 – 0.18 (p‐values<0.001). When these predicted scores were compared to observed scores, there were no significant differences (p‐values>0.40), indicating preliminary support for these prediction scores. Conclusion Although further validation is needed in independent intact and impaired samples, the current demographically‐based prediction scores provide normative data for the CERAD Word List subtest for older adults being evaluated for cognitive complaints. The inclusion of additional variables needs to be examined to improve the accuracy of these prediction scores. Nonetheless, normative data allows providers and researchers to be confident in using this learning and memory test in clinics and clinical trials.
Related Topics
Concepts
Normative
Psychology
Neuropsychology
Boston Naming Test
Neuropsychological assessment
Gerontology
Cognition
Medicine
Audiology
Clinical psychology
Psychiatry
Philosophy
Epistemology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.076991
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076991
- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.1002/alz.076991Digital Object Identifier
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Normative data on the CERAD Word List in a robustly intact sample of older adultsWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-12-01Full publication date if available
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Kevin Duff, Elise J Hanna, Nora Mattek, Madison DeCapo, Nathan Hantke, Aimee Pierce, Jeffrey KayeList of authors in order
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https://doi.org/10.1002/alz.076991Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.076991Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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