Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviors Article Swipe
Hugues Lamothe
,
Christiane Schreiweis
,
Oriana Lavielle
,
Luc Mallet
,
Eric Burguière
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.01.22.915215
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.01.22.915215
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and Tourette syndrome. Here, we meticulously analysed the behaviour of Sapap3 knockout mice, the recent rodent model predominantly used to study compulsive-like behaviours, and found that its behaviour is more complex than originally and persistently described. Indeed, we detected previously unreported elements of distinct pathologically repetitive behaviours, which do not form part of rodent syntactic cephalo-caudal self-grooming. These repetitive behaviours include sudden, rapid body and head twitches, resembling tic-like movements. We also observed that another type of repetitive behaviours, aberrant hindpaw scratching, is responsible for the flagship-like skin lesions of this mouse model, rather than originally suspected self-grooming. In order to characterize the symptomatological nature of observed repetitive behaviours, we pharmacologically challenged these phenotypes by systemic aripiprazole administration, a first-line treatment for tic-like symptoms in Tourette Syndrome and trichotillomania. A single treatment of aripiprazole significantly reduced the number of tic-like movements but not syntactic grooming events. These observations are in line with the high comorbidity of tic- and compulsive-like symptoms in Tourette, OCD and trichotillomania patients as well as with the hypothesis of shared neurobiological mechanisms.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.01.22.915215
- https://www.biorxiv.org/content/biorxiv/early/2021/01/06/2020.01.22.915215.full.pdf
- OA Status
- green
- Cited By
- 6
- References
- 96
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3121949349
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3121949349Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.01.22.915215Digital Object Identifier
- Title
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Not only compulsivity: The SAPAP3-KO mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviorsWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-23Full publication date if available
- Authors
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Hugues Lamothe, Christiane Schreiweis, Oriana Lavielle, Luc Mallet, Eric BurguièreList of authors in order
- Landing page
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https://doi.org/10.1101/2020.01.22.915215Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2021/01/06/2020.01.22.915215.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/01/06/2020.01.22.915215.full.pdfDirect OA link when available
- Concepts
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Aripiprazole, Tourette syndrome, Compulsive behavior, Psychology, Comorbidity, Tics, Pathological, Neuroscience, Tic disorder, Psychiatry, Medicine, Internal medicine, Schizophrenia (object-oriented programming)Top concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2023: 1, 2022: 1, 2021: 4Per-year citation counts (last 5 years)
- References (count)
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96Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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