Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallate Article Swipe
Kun Ismiyatin
,
Elline Elline
,
TheresiaIndah Budhy
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4103/1735-3327.372655
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.4103/1735-3327.372655
Background: Biodegradable hydrogel scaffold is one of the crucial characteristics that determine the success of pulp regeneration. The degradation should be suitable for the growth of new tissue establishment. The aim of this study is to synthesize and compare the novel biodegradable hydrogel scaffold based on hydroxyapatite (HAp) eggshell, collagen, and epigallocatechin-3-gallate (HAp-Col-EGCG) with different HAp concentrations in vitro . Materials and Methods: This study is original research. HAp-Col-EGCG hydrogel scaffolds were prepared using 1:1, 1:2, and 1:4 ratios of collagen and HAp with 10 μmol/L EGCG. The samples were freeze-dried and immersed in phosphate buffer saline containing lysozyme enzyme. The dried samples were weighed to determine the percentage of biodegradation value ( P < 0.05). Results: The result showed HAp-Col-EGCG was biodegradable but it has not been concluded that it can be completely eliminated. The data were analyzed by one-way analysis of variance and it indicated significant differences in percentage values. Conclusion: Hydrogel scaffold based on HAp-Col-EGCG can be degraded and have the potential to be used as a biodegradable scaffold in supporting tissue regeneration.
Related Topics
Concepts
Gallate
Epigallocatechin gallate
Scaffold
Chemistry
Biomedical engineering
Nuclear chemistry
Medicine
Biochemistry
Polyphenol
Antioxidant
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/1735-3327.372655
- OA Status
- gold
- Cited By
- 3
- References
- 16
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All OpenAlex metadata
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https://openalex.org/W4361771800Canonical identifier for this work in OpenAlex
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https://doi.org/10.4103/1735-3327.372655Digital Object Identifier
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Novel biodegradable hydrogel scaffold based on hydroxyapatite eggshell, collagen, and epigallocatechin-3-gallateWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-03-01Full publication date if available
- Authors
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Kun Ismiyatin, Elline Elline, TheresiaIndah BudhyList of authors in order
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https://doi.org/10.4103/1735-3327.372655Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.4103/1735-3327.372655Direct OA link when available
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Gallate, Epigallocatechin gallate, Scaffold, Chemistry, Biomedical engineering, Nuclear chemistry, Medicine, Biochemistry, Polyphenol, AntioxidantTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 2, 2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| publication_year | 2023 |
| referenced_works | https://openalex.org/W2943498539, https://openalex.org/W2460944735, https://openalex.org/W2282045282, https://openalex.org/W2606014787, https://openalex.org/W2265225559, https://openalex.org/W2945276416, https://openalex.org/W2901334632, https://openalex.org/W2955050310, https://openalex.org/W4200420962, https://openalex.org/W3207925752, https://openalex.org/W6740066348, https://openalex.org/W3111495327, https://openalex.org/W3194611878, https://openalex.org/W2063126867, https://openalex.org/W2944784158, https://openalex.org/W2676409082 |
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