Novel Insights Into the Interaction Between the Autonomic Nervous System and Inflammation on Coronary Physiology: A Quantitative Flow Ratio Study Article Swipe
Jun Wang
,
Wei Liu
,
Huaqiang Chen
,
Chengzhe Liu
,
Meng Wang
,
Hu Chen
,
Huixin Zhou
,
Zhihao Liu
,
Song Zhang
,
Zhongyang Yu
,
Shoupeng Duan
,
Qiang Deng
,
Ji Sun
,
Hong Jiang
,
Lilei Yu
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.700943
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2021.700943
Background: Heart rate variability (HRV) was proposed as a noninvasive biomarker to stratify the risk of cardiovascular disease. However, it remains to be determined if HRV can be used as a surrogate for coronary artery physiology as analyzed by quantitative flow ratio (QFR) in patients with new-onset unstable angina pectoris (UAP). Methods: A total of 129 consecutive patients with new-onset UAP who underwent 24-h long-range 12-channel electrocardiography from June 2020 to December 2020 were included in this study. HRV, coronary angiography, and QFR information was retrieved from patient medical records, the severity of coronary lesions was evaluated using the Gensini score (GS), and total atherosclerotic burden was assessed using the three-vessel contrast QFR (3V-cQFR) calculated as the sum of cQFR in three vessels. Results: Multivariate logistic analysis showed that low-frequency power (LF) and high-sensitivity C-reactive protein (hs-CRP) were directly correlated with functional ischemia of target vessel, which were inversely correlated with total atherosclerotic burden as assessed by 3V-cQFR. Moreover, incorporation of the increase in LF into the existing model that uses clinical risk factors, GS, and hs-CRP significantly increased the discriminatory ability for evaluating coronary artery physiology of target vessel. Conclusions: LF and hs-CRP are independently associated with functional ischemia in patients with new-onset UAP. The relative increase of LF and hs-CRP could add value to the use of classical cardiovascular risk factors to predict the functional severity of coronary artery stenosis. Our results suggest a potential association between the autonomic nervous system, inflammation, and coronary artery physiology.
Related Topics
Concepts
Medicine
Cardiology
Internal medicine
Fractional flow reserve
Heart rate variability
Coronary artery disease
Unstable angina
Stenosis
Angina
Biomarker
Heart rate
Ischemia
Coronary angiography
Blood pressure
Myocardial infarction
Biochemistry
Chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2021.700943
- https://www.frontiersin.org/articles/10.3389/fcvm.2021.700943/pdf
- OA Status
- gold
- Cited By
- 20
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3198712534
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3198712534Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fcvm.2021.700943Digital Object Identifier
- Title
-
Novel Insights Into the Interaction Between the Autonomic Nervous System and Inflammation on Coronary Physiology: A Quantitative Flow Ratio StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-27Full publication date if available
- Authors
-
Jun Wang, Wei Liu, Huaqiang Chen, Chengzhe Liu, Meng Wang, Hu Chen, Huixin Zhou, Zhihao Liu, Song Zhang, Zhongyang Yu, Shoupeng Duan, Qiang Deng, Ji Sun, Hong Jiang, Lilei YuList of authors in order
- Landing page
-
https://doi.org/10.3389/fcvm.2021.700943Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fcvm.2021.700943/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fcvm.2021.700943/pdfDirect OA link when available
- Concepts
-
Medicine, Cardiology, Internal medicine, Fractional flow reserve, Heart rate variability, Coronary artery disease, Unstable angina, Stenosis, Angina, Biomarker, Heart rate, Ischemia, Coronary angiography, Blood pressure, Myocardial infarction, Biochemistry, ChemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 9, 2023: 3, 2022: 5Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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