Novel multiphase loop reactor with improved aeration prevents excessive foaming in Rhamnolipid production by Pseudomonas putida Article Swipe
Maximilian von Campenhausen
,
Philipp Demling
,
Patrick Bongartz
,
Alexander Scheele
,
Till Tiso
,
Matthias Weßling
,
Lars M. Blank
,
Andreas Jupke
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s43938-023-00018-5
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s43938-023-00018-5
Rhamnolipids are biosurfactants that tend to cause strong foaming, making microbial production in an aerated stirred tank fermenter challenging. The continuous removal of rhamnolipids from the cultivation broth via in situ liquid-liquid extraction can remedy this foam challenge, and thereby supports long-term cultivation and production. However, for efficient processing and stable phase separation, a specialized apparatus is required. In this study, the novel multiphase loop reactor, which is a modified airlift reactor with an internal loop enabling continuous in situ liquid-liquid extraction, was designed and adapted to produce rhamnolipids with a recombinant bacterium, Pseudomonas putida KT2440. The initially designed multiphase loop reactor showed a low oxygen transfer rate, unable to meet the oxygen demand of the whole-cell biocatalyst, resulting in inefficient growth and production. A re-design of the sparger via 3D printing enabled a high oxygen supply allowing rhamnolipid production at key performance indicators that matched stirred-tank reactor cultivations. Advantageously, the multiphase loop reactor allowed stable and constant phase separation and solvent removal enabling continuous cultivation in the future. Concluding, the successful use of the multiphase loop reactor for rhamnolipid synthesis is presented, highlighting its potential to become a new platform technology for intensified bioprocessing.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s43938-023-00018-5
- https://link.springer.com/content/pdf/10.1007/s43938-023-00018-5.pdf
- OA Status
- gold
- Cited By
- 8
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4317391241
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4317391241Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s43938-023-00018-5Digital Object Identifier
- Title
-
Novel multiphase loop reactor with improved aeration prevents excessive foaming in Rhamnolipid production by Pseudomonas putidaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-18Full publication date if available
- Authors
-
Maximilian von Campenhausen, Philipp Demling, Patrick Bongartz, Alexander Scheele, Till Tiso, Matthias Weßling, Lars M. Blank, Andreas JupkeList of authors in order
- Landing page
-
https://doi.org/10.1007/s43938-023-00018-5Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s43938-023-00018-5.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s43938-023-00018-5.pdfDirect OA link when available
- Concepts
-
Rhamnolipid, Bioprocess, Aeration, Sparging, Pseudomonas putida, Airlift, Bioreactor, Continuous stirred-tank reactor, Process engineering, Chemical engineering, Materials science, Pulp and paper industry, Chemistry, Bacteria, Pseudomonas aeruginosa, Organic chemistry, Engineering, Biology, Genetics, EnzymeTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 6, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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