Novel Retro-Inverso Peptide Antibiotic Efficiently Released by a Responsive Hydrogel-Based System Article Swipe
Angela Cesaro
,
Rosa Gaglione
,
Marco Chino
,
Maria De Luca
,
Rocco Di Girolamo
,
Angela Lombardi
,
Rosanna Filosa
,
Angela Arciello
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10061301
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10061301
Topical antimicrobial treatments are often ineffective on recalcitrant and resistant skin infections. This necessitates the design of antimicrobials that are less susceptible to resistance mechanisms, as well as the development of appropriate delivery systems. These two issues represent a great challenge for researchers in pharmaceutical and drug discovery fields. Here, we defined the therapeutic properties of a novel peptidomimetic inspired by an antimicrobial sequence encrypted in human apolipoprotein B. The peptidomimetic was found to exhibit antimicrobial and anti-biofilm properties at concentration values ranging from 2.5 to 20 µmol L−1, to be biocompatible toward human skin cell lines, and to protect human keratinocytes from bacterial infections being able to induce a reduction of bacterial units by two or even four orders of magnitude with respect to untreated samples. Based on these promising results, a hyaluronic-acid-based hydrogel was devised to encapsulate and to specifically deliver the selected antimicrobial agent to the site of infection. The developed hydrogel-based system represents a promising, effective therapeutic option by combining the mechanical properties of the hyaluronic acid polymer with the anti-infective activity of the antimicrobial peptidomimetic, thus opening novel perspectives in the treatment of skin infections.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines10061301
- https://www.mdpi.com/2227-9059/10/6/1301/pdf?version=1654156071
- OA Status
- gold
- Cited By
- 9
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281769953
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4281769953Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines10061301Digital Object Identifier
- Title
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Novel Retro-Inverso Peptide Antibiotic Efficiently Released by a Responsive Hydrogel-Based SystemWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-02Full publication date if available
- Authors
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Angela Cesaro, Rosa Gaglione, Marco Chino, Maria De Luca, Rocco Di Girolamo, Angela Lombardi, Rosanna Filosa, Angela ArcielloList of authors in order
- Landing page
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https://doi.org/10.3390/biomedicines10061301Publisher landing page
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https://www.mdpi.com/2227-9059/10/6/1301/pdf?version=1654156071Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/10/6/1301/pdf?version=1654156071Direct OA link when available
- Concepts
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Peptide, Antibiotics, Chemistry, Microbiology, Biochemistry, BiologyTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2025: 1, 2024: 4, 2023: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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