Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species Article Swipe
Marius Seethaler
,
Tobias Hertlein
,
Björn Wecklein
,
Alba Ymeraj
,
Knut Ohlsen
,
Michael Lalk
,
Andreas Hilgeroth
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics8040210
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics8040210
Defeat of the antibiotic resistance of pathogenic bacteria is one great challenge today and for the future. In the last century many classes of effective antibacterials have been developed, so that upcoming resistances could be met with novel drugs of various compound classes. Meanwhile, there is a certain lack of research of the pharmaceutical companies, and thus there are missing developments of novel antibiotics. Gram-positive bacteria are the most important cause of clinical infections. The number of novel antibacterials in clinical trials is strongly restricted. There is an urgent need to find novel antibacterials. We used synthetic chemistry to build completely novel hybrid molecules of substituted indoles and benzothiophene. In a simple one-pot reaction, two novel types of thienocarbazoles were yielded. Both indole substituted compound classes have been evaluated as completely novel antibacterials against the Staphylococcus and Enterococcus species. The evaluated partly promising activities depend on the indole substituent type. First lead compounds have been evaluated within in vivo studies. They confirmed the in vitro results for the new classes of small-molecule antibacterials.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics8040210
- https://www.mdpi.com/2079-6382/8/4/210/pdf?version=1572681412
- OA Status
- gold
- Cited By
- 11
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2987397387
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2987397387Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antibiotics8040210Digital Object Identifier
- Title
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Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus SpeciesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-02Full publication date if available
- Authors
-
Marius Seethaler, Tobias Hertlein, Björn Wecklein, Alba Ymeraj, Knut Ohlsen, Michael Lalk, Andreas HilgerothList of authors in order
- Landing page
-
https://doi.org/10.3390/antibiotics8040210Publisher landing page
- PDF URL
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https://www.mdpi.com/2079-6382/8/4/210/pdf?version=1572681412Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2079-6382/8/4/210/pdf?version=1572681412Direct OA link when available
- Concepts
-
Antibiotics, Enterococcus, Microbiology, Staphylococcus aureus, Antibacterial activity, Bacteria, Pathogenic bacteria, Biology, Chemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 2, 2022: 1, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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