Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics Article Swipe
Nazilah Abdul Satar
,
Kamal Shaik Fakiruddin
,
Moon Nian Lim
,
Pooi Ling Mok
,
Norashikin Zakaria
,
Noor Atiqah Fakharuzi
,
Ahmad Zuhairi Abd Rahman
,
Zubaidah Zakaria
,
Badrul Hisham Yahaya
,
Puteri Baharuddin
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/or.2018.6461
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3892/or.2018.6461
Through the specific identification and direct targeting of cancer stem cells (CSCs), it is believed that a better treatment efficacy of cancer may be achieved. Hence, the present study aimed to identify a CSC subpopulation from adenocarcinoma cells (A549) as a model of non‑small cell lung cancer (NSCLC). Ιnitially, we sorted two subpopulations known as the triple‑positive (EpCAM+/CD166+/CD44+) and triple‑negative (EpCAM-/CD166-/CD44-) subpopulation using fluorescence-activated cell sorting (FACS). Sorted cells were subsequently evaluated for proliferation and chemotherapy-resistance using a viability assay and were further characterized for their clonal heterogeneity, self-renewal characteristics, cellular migration, alkaline dehydrogenase (ALDH) activity and the expression of stemness-related genes. According to our findings the triple‑positive subpopulation revealed significantly higher (P<0.01) proliferation activity, exhibited better clonogenicity, was mostly comprised of holoclones and had markedly bigger (P<0.001) spheroid formation indicating a better self-renewal capacity. A relatively higher resistance to both 5‑fluouracil and cisplatin with 80% expression of ALDH was observed in the triple‑positive subpopulation, compared to only 67% detected in the triple‑negative subpopulation indicated that high ALDH activity contributed to greater chemotherapy-resistance characteristics. Higher percentage of migrated cells was observed in the triple‑positive subpopulation with 56% cellular migration being detected, compared to only 19% in the triple‑negative subpopulation on day 2. This was similarly observed on day 3 in the triple‑positive subpopulation with 36% higher cellular migration compared to the triple‑negative subpopulation. Consistently, elevated levels of the stem cell genes such as REX1 and SSEA4 were also found in the triple‑positive subpopulation indicating that the subpopulation displayed a strong characteristic of pluripotency. In conclusion, our study revealed that the triple‑positive subpopulation demonstrated similar characteristics to CSCs compared to the triple‑negative subpopulation. It also confirmed the feasibility of using the triple‑positive (EpCAM+/CD166+/CD44+) marker as a novel candidate marker that may lead to the development of novel therapies targeting CSCs of NSCLC.
Related Topics
Concepts
CD44
Cancer stem cell
Biology
Cancer research
Triple-negative breast cancer
Stem cell
Cancer
Cell sorting
Oncogene
Cell cycle
Lung cancer
Stem cell marker
Cell
Molecular biology
Pathology
Flow cytometry
Medicine
Cell biology
Genetics
Breast cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/or.2018.6461
- http://www.spandidos-publications.com/10.3892/or.2018.6461/download
- OA Status
- hybrid
- Cited By
- 52
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2804877425
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2804877425Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/or.2018.6461Digital Object Identifier
- Title
-
Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-05-24Full publication date if available
- Authors
-
Nazilah Abdul Satar, Kamal Shaik Fakiruddin, Moon Nian Lim, Pooi Ling Mok, Norashikin Zakaria, Noor Atiqah Fakharuzi, Ahmad Zuhairi Abd Rahman, Zubaidah Zakaria, Badrul Hisham Yahaya, Puteri BaharuddinList of authors in order
- Landing page
-
https://doi.org/10.3892/or.2018.6461Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/or.2018.6461/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/or.2018.6461/downloadDirect OA link when available
- Concepts
-
CD44, Cancer stem cell, Biology, Cancer research, Triple-negative breast cancer, Stem cell, Cancer, Cell sorting, Oncogene, Cell cycle, Lung cancer, Stem cell marker, Cell, Molecular biology, Pathology, Flow cytometry, Medicine, Cell biology, Genetics, Breast cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
52Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 12, 2023: 8, 2022: 13, 2021: 8Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2804877425 |
|---|---|
| doi | https://doi.org/10.3892/or.2018.6461 |
| ids.doi | https://doi.org/10.3892/or.2018.6461 |
| ids.mag | 2804877425 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29845263 |
| ids.openalex | https://openalex.org/W2804877425 |
| fwci | 1.78336799 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000072283 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | A549 Cells |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D020410 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Activated-Leukocyte Cell Adhesion Molecule |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D014408 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Biomarkers, Tumor |
| mesh[3].qualifier_ui | Q000188 |
| mesh[3].descriptor_ui | D002289 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | drug therapy |
| mesh[3].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D002289 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D002289 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D045744 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Cell Line, Tumor |
| mesh[7].qualifier_ui | Q000187 |
| mesh[7].descriptor_ui | D002465 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | drug effects |
| mesh[7].descriptor_name | Cell Movement |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D002465 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Cell Movement |
| mesh[9].qualifier_ui | Q000187 |
| mesh[9].descriptor_ui | D049109 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | drug effects |
| mesh[9].descriptor_name | Cell Proliferation |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D049109 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Cell Proliferation |
| mesh[11].qualifier_ui | Q000494 |
| mesh[11].descriptor_ui | D002945 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | pharmacology |
| mesh[11].descriptor_name | Cisplatin |
| mesh[12].qualifier_ui | Q000187 |
| mesh[12].descriptor_ui | D019008 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | drug effects |
| mesh[12].descriptor_name | Drug Resistance, Neoplasm |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D019008 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Drug Resistance, Neoplasm |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D000071858 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Epithelial Cell Adhesion Molecule |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D006801 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Humans |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D018960 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Hyaluronan Receptors |
| mesh[17].qualifier_ui | Q000188 |
| mesh[17].descriptor_ui | D008175 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | drug therapy |
| mesh[17].descriptor_name | Lung Neoplasms |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D008175 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Lung Neoplasms |
| mesh[19].qualifier_ui | Q000473 |
| mesh[19].descriptor_ui | D008175 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pathology |
| mesh[19].descriptor_name | Lung Neoplasms |
| mesh[20].qualifier_ui | Q000187 |
| mesh[20].descriptor_ui | D014411 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | drug effects |
| mesh[20].descriptor_name | Neoplastic Stem Cells |
| mesh[21].qualifier_ui | Q000473 |
| mesh[21].descriptor_ui | D014411 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pathology |
| mesh[21].descriptor_name | Neoplastic Stem Cells |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000072283 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | A549 Cells |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D020410 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | Activated-Leukocyte Cell Adhesion Molecule |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D014408 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Biomarkers, Tumor |
| mesh[25].qualifier_ui | Q000188 |
| mesh[25].descriptor_ui | D002289 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | drug therapy |
| mesh[25].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[26].qualifier_ui | Q000235 |
| mesh[26].descriptor_ui | D002289 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | genetics |
| mesh[26].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[27].qualifier_ui | Q000473 |
| mesh[27].descriptor_ui | D002289 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | pathology |
| mesh[27].descriptor_name | Carcinoma, Non-Small-Cell Lung |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D045744 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Cell Line, Tumor |
| mesh[29].qualifier_ui | Q000187 |
| mesh[29].descriptor_ui | D002465 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | drug effects |
| mesh[29].descriptor_name | Cell Movement |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D002465 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Cell Movement |
| mesh[31].qualifier_ui | Q000187 |
| mesh[31].descriptor_ui | D049109 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug effects |
| mesh[31].descriptor_name | Cell Proliferation |
| mesh[32].qualifier_ui | Q000235 |
| mesh[32].descriptor_ui | D049109 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | genetics |
| mesh[32].descriptor_name | Cell Proliferation |
| mesh[33].qualifier_ui | Q000494 |
| mesh[33].descriptor_ui | D002945 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pharmacology |
| mesh[33].descriptor_name | Cisplatin |
| mesh[34].qualifier_ui | Q000187 |
| mesh[34].descriptor_ui | D019008 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | drug effects |
| mesh[34].descriptor_name | Drug Resistance, Neoplasm |
| mesh[35].qualifier_ui | Q000235 |
| mesh[35].descriptor_ui | D019008 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | genetics |
| mesh[35].descriptor_name | Drug Resistance, Neoplasm |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D000071858 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Epithelial Cell Adhesion Molecule |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D006801 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Humans |
| mesh[38].qualifier_ui | Q000235 |
| mesh[38].descriptor_ui | D018960 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | genetics |
| mesh[38].descriptor_name | Hyaluronan Receptors |
| mesh[39].qualifier_ui | Q000188 |
| mesh[39].descriptor_ui | D008175 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | drug therapy |
| mesh[39].descriptor_name | Lung Neoplasms |
| mesh[40].qualifier_ui | Q000235 |
| mesh[40].descriptor_ui | D008175 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | genetics |
| mesh[40].descriptor_name | Lung Neoplasms |
| mesh[41].qualifier_ui | Q000473 |
| mesh[41].descriptor_ui | D008175 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | pathology |
| mesh[41].descriptor_name | Lung Neoplasms |
| mesh[42].qualifier_ui | Q000187 |
| mesh[42].descriptor_ui | D014411 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | drug effects |
| mesh[42].descriptor_name | Neoplastic Stem Cells |
| mesh[43].qualifier_ui | Q000473 |
| mesh[43].descriptor_ui | D014411 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | pathology |
| mesh[43].descriptor_name | Neoplastic Stem Cells |
| type | article |
| title | Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics |
| biblio.issue | 2 |
| biblio.volume | 40 |
| biblio.last_page | 681 |
| biblio.first_page | 669 |
| topics[0].id | https://openalex.org/T10336 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Cancer Cells and Metastasis |
| topics[1].id | https://openalex.org/T11287 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9958999752998352 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | Cancer Genomics and Diagnostics |
| topics[2].id | https://openalex.org/T10231 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9887999892234802 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2730 |
| topics[2].subfield.display_name | Oncology |
| topics[2].display_name | Pancreatic and Hepatic Oncology Research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2780932548 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7937188744544983 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1056532 |
| concepts[0].display_name | CD44 |
| concepts[1].id | https://openalex.org/C55427017 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7116301655769348 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1638475 |
| concepts[1].display_name | Cancer stem cell |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6626858115196228 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C502942594 |
| concepts[3].level | 1 |
| concepts[3].score | 0.62079918384552 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[3].display_name | Cancer research |
| concepts[4].id | https://openalex.org/C2780110267 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5193332433700562 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7843332 |
| concepts[4].display_name | Triple-negative breast cancer |
| concepts[5].id | https://openalex.org/C28328180 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5060893893241882 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[5].display_name | Stem cell |
| concepts[6].id | https://openalex.org/C121608353 |
| concepts[6].level | 2 |
| concepts[6].score | 0.47741639614105225 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[6].display_name | Cancer |
| concepts[7].id | https://openalex.org/C2778630268 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4734190106391907 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q17113277 |
| concepts[7].display_name | Cell sorting |
| concepts[8].id | https://openalex.org/C2781018059 |
| concepts[8].level | 4 |
| concepts[8].score | 0.4526233673095703 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q207609 |
| concepts[8].display_name | Oncogene |
| concepts[9].id | https://openalex.org/C29537977 |
| concepts[9].level | 3 |
| concepts[9].score | 0.4485003352165222 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q188941 |
| concepts[9].display_name | Cell cycle |
| concepts[10].id | https://openalex.org/C2776256026 |
| concepts[10].level | 2 |
| concepts[10].score | 0.44791069626808167 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q47912 |
| concepts[10].display_name | Lung cancer |
| concepts[11].id | https://openalex.org/C136302470 |
| concepts[11].level | 3 |
| concepts[11].score | 0.410104364156723 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7607299 |
| concepts[11].display_name | Stem cell marker |
| concepts[12].id | https://openalex.org/C1491633281 |
| concepts[12].level | 2 |
| concepts[12].score | 0.3754352033138275 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7868 |
| concepts[12].display_name | Cell |
| concepts[13].id | https://openalex.org/C153911025 |
| concepts[13].level | 1 |
| concepts[13].score | 0.3255741596221924 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[13].display_name | Molecular biology |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.22069162130355835 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C553184892 |
| concepts[15].level | 2 |
| concepts[15].score | 0.2121162712574005 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q1141429 |
| concepts[15].display_name | Flow cytometry |
| concepts[16].id | https://openalex.org/C71924100 |
| concepts[16].level | 0 |
| concepts[16].score | 0.12834042310714722 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[16].display_name | Medicine |
| concepts[17].id | https://openalex.org/C95444343 |
| concepts[17].level | 1 |
| concepts[17].score | 0.12018746137619019 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[17].display_name | Cell biology |
| concepts[18].id | https://openalex.org/C54355233 |
| concepts[18].level | 1 |
| concepts[18].score | 0.08530190587043762 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[18].display_name | Genetics |
| concepts[19].id | https://openalex.org/C530470458 |
| concepts[19].level | 3 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q128581 |
| concepts[19].display_name | Breast cancer |
| keywords[0].id | https://openalex.org/keywords/cd44 |
| keywords[0].score | 0.7937188744544983 |
| keywords[0].display_name | CD44 |
| keywords[1].id | https://openalex.org/keywords/cancer-stem-cell |
| keywords[1].score | 0.7116301655769348 |
| keywords[1].display_name | Cancer stem cell |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.6626858115196228 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/cancer-research |
| keywords[3].score | 0.62079918384552 |
| keywords[3].display_name | Cancer research |
| keywords[4].id | https://openalex.org/keywords/triple-negative-breast-cancer |
| keywords[4].score | 0.5193332433700562 |
| keywords[4].display_name | Triple-negative breast cancer |
| keywords[5].id | https://openalex.org/keywords/stem-cell |
| keywords[5].score | 0.5060893893241882 |
| keywords[5].display_name | Stem cell |
| keywords[6].id | https://openalex.org/keywords/cancer |
| keywords[6].score | 0.47741639614105225 |
| keywords[6].display_name | Cancer |
| keywords[7].id | https://openalex.org/keywords/cell-sorting |
| keywords[7].score | 0.4734190106391907 |
| keywords[7].display_name | Cell sorting |
| keywords[8].id | https://openalex.org/keywords/oncogene |
| keywords[8].score | 0.4526233673095703 |
| keywords[8].display_name | Oncogene |
| keywords[9].id | https://openalex.org/keywords/cell-cycle |
| keywords[9].score | 0.4485003352165222 |
| keywords[9].display_name | Cell cycle |
| keywords[10].id | https://openalex.org/keywords/lung-cancer |
| keywords[10].score | 0.44791069626808167 |
| keywords[10].display_name | Lung cancer |
| keywords[11].id | https://openalex.org/keywords/stem-cell-marker |
| keywords[11].score | 0.410104364156723 |
| keywords[11].display_name | Stem cell marker |
| keywords[12].id | https://openalex.org/keywords/cell |
| keywords[12].score | 0.3754352033138275 |
| keywords[12].display_name | Cell |
| keywords[13].id | https://openalex.org/keywords/molecular-biology |
| keywords[13].score | 0.3255741596221924 |
| keywords[13].display_name | Molecular biology |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.22069162130355835 |
| keywords[14].display_name | Pathology |
| keywords[15].id | https://openalex.org/keywords/flow-cytometry |
| keywords[15].score | 0.2121162712574005 |
| keywords[15].display_name | Flow cytometry |
| keywords[16].id | https://openalex.org/keywords/medicine |
| keywords[16].score | 0.12834042310714722 |
| keywords[16].display_name | Medicine |
| keywords[17].id | https://openalex.org/keywords/cell-biology |
| keywords[17].score | 0.12018746137619019 |
| keywords[17].display_name | Cell biology |
| keywords[18].id | https://openalex.org/keywords/genetics |
| keywords[18].score | 0.08530190587043762 |
| keywords[18].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.3892/or.2018.6461 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S124357017 |
| locations[0].source.issn | 1021-335X, 1791-2431 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1021-335X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Oncology Reports |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | http://www.spandidos-publications.com/10.3892/or.2018.6461/download |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Oncology Reports |
| locations[0].landing_page_url | https://doi.org/10.3892/or.2018.6461 |
| locations[1].id | pmid:29845263 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Oncology reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29845263 |
| locations[2].id | pmh:oai:psasir.upm.edu.my:75094 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4377196260 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) |
| locations[2].source.host_organization | https://openalex.org/I130343225 |
| locations[2].source.host_organization_name | Universiti Putra Malaysia |
| locations[2].source.host_organization_lineage | https://openalex.org/I130343225 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | Article |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | |
| locations[3].id | pmh:oai:europepmc.org:5034029 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6072294 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5002490293 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Nazilah Abdul Satar |
| authorships[0].countries | MY |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I139322472 |
| authorships[0].affiliations[0].raw_affiliation_string | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[0].institutions[0].id | https://openalex.org/I139322472 |
| authorships[0].institutions[0].ror | https://ror.org/02rgb2k63 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I139322472 |
| authorships[0].institutions[0].country_code | MY |
| authorships[0].institutions[0].display_name | Universiti Sains Malaysia |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Nazilah Satar |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[1].author.id | https://openalex.org/A5080716167 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3646-3317 |
| authorships[1].author.display_name | Kamal Shaik Fakiruddin |
| authorships[1].countries | MY |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[1].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[1].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[1].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[1].institutions[0].country_code | MY |
| authorships[1].institutions[0].display_name | Institute for Medical Research |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kamal Fakiruddin |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[2].author.id | https://openalex.org/A5112367732 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Moon Nian Lim |
| authorships[2].countries | MY |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[2].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[2].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[2].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[2].institutions[0].country_code | MY |
| authorships[2].institutions[0].display_name | Institute for Medical Research |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Moon Lim |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[3].author.id | https://openalex.org/A5030463117 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9688-0716 |
| authorships[3].author.display_name | Pooi Ling Mok |
| authorships[3].countries | MY |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I130343225 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor |
| authorships[3].institutions[0].id | https://openalex.org/I130343225 |
| authorships[3].institutions[0].ror | https://ror.org/02e91jd64 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I130343225 |
| authorships[3].institutions[0].country_code | MY |
| authorships[3].institutions[0].display_name | Universiti Putra Malaysia |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Pooi Mok |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor |
| authorships[4].author.id | https://openalex.org/A5023396184 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2589-1543 |
| authorships[4].author.display_name | Norashikin Zakaria |
| authorships[4].countries | MY |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I139322472 |
| authorships[4].affiliations[0].raw_affiliation_string | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[4].institutions[0].id | https://openalex.org/I139322472 |
| authorships[4].institutions[0].ror | https://ror.org/02rgb2k63 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I139322472 |
| authorships[4].institutions[0].country_code | MY |
| authorships[4].institutions[0].display_name | Universiti Sains Malaysia |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Norashikin Zakaria |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[5].author.id | https://openalex.org/A5034486101 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Noor Atiqah Fakharuzi |
| authorships[5].countries | MY |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[5].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[5].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[5].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[5].institutions[0].country_code | MY |
| authorships[5].institutions[0].display_name | Institute for Medical Research |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Noor Fakharuzi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[6].author.id | https://openalex.org/A5089502258 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6489-5072 |
| authorships[6].author.display_name | Ahmad Zuhairi Abd Rahman |
| authorships[6].countries | MY |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[6].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[6].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[6].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[6].institutions[0].country_code | MY |
| authorships[6].institutions[0].display_name | Institute for Medical Research |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ahmad Abd Rahman |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[7].author.id | https://openalex.org/A5103892098 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Zubaidah Zakaria |
| authorships[7].countries | MY |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[7].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[7].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[7].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[7].institutions[0].country_code | MY |
| authorships[7].institutions[0].display_name | Institute for Medical Research |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Zubaidah Zakaria |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[8].author.id | https://openalex.org/A5019202801 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3295-9676 |
| authorships[8].author.display_name | Badrul Hisham Yahaya |
| authorships[8].countries | MY |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I139322472 |
| authorships[8].affiliations[0].raw_affiliation_string | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[8].institutions[0].id | https://openalex.org/I139322472 |
| authorships[8].institutions[0].ror | https://ror.org/02rgb2k63 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I139322472 |
| authorships[8].institutions[0].country_code | MY |
| authorships[8].institutions[0].display_name | Universiti Sains Malaysia |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Badrul Yahaya |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Regenerative Medicine Cluster, Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200 Penang, Malaysia |
| authorships[9].author.id | https://openalex.org/A5109100613 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Puteri Baharuddin |
| authorships[9].countries | MY |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210130795 |
| authorships[9].affiliations[0].raw_affiliation_string | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| authorships[9].institutions[0].id | https://openalex.org/I4210130795 |
| authorships[9].institutions[0].ror | https://ror.org/03bpc5f92 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210130795 |
| authorships[9].institutions[0].country_code | MY |
| authorships[9].institutions[0].display_name | Institute for Medical Research |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Puteri Baharuddin |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Stem Cell Laboratory, Haematology Unit, Cancer Research Centre, Institute for Medical Research (IMR), 50588 Kuala Lumpur, Malaysia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.spandidos-publications.com/10.3892/or.2018.6461/download |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10336 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Cancer Cells and Metastasis |
| related_works | https://openalex.org/W1997280228, https://openalex.org/W2071015820, https://openalex.org/W1983201135, https://openalex.org/W2313149101, https://openalex.org/W2120477152, https://openalex.org/W2085362515, https://openalex.org/W2138240309, https://openalex.org/W2428107380, https://openalex.org/W4353088593, https://openalex.org/W2804877425 |
| cited_by_count | 52 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 12 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 13 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 8 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 4 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 3 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3892/or.2018.6461 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S124357017 |
| best_oa_location.source.issn | 1021-335X, 1791-2431 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1021-335X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Oncology Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_lineage_names | Elsevier BV |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | http://www.spandidos-publications.com/10.3892/or.2018.6461/download |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Oncology Reports |
| best_oa_location.landing_page_url | https://doi.org/10.3892/or.2018.6461 |
| primary_location.id | doi:10.3892/or.2018.6461 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S124357017 |
| primary_location.source.issn | 1021-335X, 1791-2431 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1021-335X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Oncology Reports |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | http://www.spandidos-publications.com/10.3892/or.2018.6461/download |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Oncology Reports |
| primary_location.landing_page_url | https://doi.org/10.3892/or.2018.6461 |
| publication_date | 2018-05-24 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2478338227, https://openalex.org/W138860792, https://openalex.org/W2413014235, https://openalex.org/W26839700, https://openalex.org/W2111709864, https://openalex.org/W1821813067, https://openalex.org/W2158627893, https://openalex.org/W2038206806, https://openalex.org/W2130697526, https://openalex.org/W2105680453, https://openalex.org/W2049410632, https://openalex.org/W2113933705, https://openalex.org/W2092778532, https://openalex.org/W2045852353, https://openalex.org/W2143899065, https://openalex.org/W2151386025, https://openalex.org/W2068990310, https://openalex.org/W4247211370, https://openalex.org/W2084996794, https://openalex.org/W2037749974, https://openalex.org/W2105916911, https://openalex.org/W2098585582, https://openalex.org/W1510757103, https://openalex.org/W2097959454, https://openalex.org/W2005356516, https://openalex.org/W2151705439, https://openalex.org/W2151879335, https://openalex.org/W2030854898, https://openalex.org/W2019264784, https://openalex.org/W2024520801, https://openalex.org/W2127107445, https://openalex.org/W2766270233, https://openalex.org/W2157158939, https://openalex.org/W2412509206, https://openalex.org/W2564891787, https://openalex.org/W2187677205, https://openalex.org/W2129644533, https://openalex.org/W2028593825, https://openalex.org/W2062069198, https://openalex.org/W2004624656, https://openalex.org/W2085613922, https://openalex.org/W2159889514, https://openalex.org/W2112535219, https://openalex.org/W2095069572, https://openalex.org/W1979580372, https://openalex.org/W2158741313, https://openalex.org/W1996590048, https://openalex.org/W2013315155, https://openalex.org/W1596376889, https://openalex.org/W2019309092, https://openalex.org/W2093238681, https://openalex.org/W2313822720, https://openalex.org/W1971981581, https://openalex.org/W1992676863, https://openalex.org/W2014341006, https://openalex.org/W1999356404, https://openalex.org/W2083530483, https://openalex.org/W2032009340, https://openalex.org/W1987604182, https://openalex.org/W1876073362, https://openalex.org/W1889670825, https://openalex.org/W2159588477, https://openalex.org/W2093405022, https://openalex.org/W2023427658, https://openalex.org/W2102085111, https://openalex.org/W1990099538, https://openalex.org/W2152627545, https://openalex.org/W2150526060, https://openalex.org/W1997317582, https://openalex.org/W2105504936, https://openalex.org/W2037150116 |
| referenced_works_count | 71 |
| abstract_inverted_index.3 | 208 |
| abstract_inverted_index.A | 135 |
| abstract_inverted_index.a | 16, 32, 40, 77, 131, 248, 284 |
| abstract_inverted_index.2. | 201 |
| abstract_inverted_index.In | 253 |
| abstract_inverted_index.It | 272 |
| abstract_inverted_index.as | 39, 54, 232, 283 |
| abstract_inverted_index.be | 23 |
| abstract_inverted_index.in | 151, 160, 181, 195, 209, 239 |
| abstract_inverted_index.is | 13 |
| abstract_inverted_index.it | 12 |
| abstract_inverted_index.of | 7, 20, 42, 99, 121, 147, 176, 226, 251, 277, 294, 299 |
| abstract_inverted_index.on | 199, 206 |
| abstract_inverted_index.to | 30, 103, 139, 156, 170, 192, 219, 265, 268, 291 |
| abstract_inverted_index.we | 49 |
| abstract_inverted_index.19% | 194 |
| abstract_inverted_index.36% | 214 |
| abstract_inverted_index.56% | 186 |
| abstract_inverted_index.67% | 158 |
| abstract_inverted_index.80% | 145 |
| abstract_inverted_index.CSC | 33 |
| abstract_inverted_index.and | 4, 58, 74, 80, 96, 123, 142, 234 |
| abstract_inverted_index.day | 200, 207 |
| abstract_inverted_index.for | 72, 84 |
| abstract_inverted_index.had | 124 |
| abstract_inverted_index.may | 22, 289 |
| abstract_inverted_index.our | 104, 255 |
| abstract_inverted_index.the | 1, 26, 55, 97, 106, 152, 161, 182, 196, 210, 220, 227, 240, 245, 259, 269, 275, 279, 292 |
| abstract_inverted_index.two | 51 |
| abstract_inverted_index.was | 118, 149, 179, 203 |
| abstract_inverted_index.ALDH | 148, 167 |
| abstract_inverted_index.CSCs | 266, 298 |
| abstract_inverted_index.REX1 | 233 |
| abstract_inverted_index.This | 202 |
| abstract_inverted_index.also | 237, 273 |
| abstract_inverted_index.both | 140 |
| abstract_inverted_index.cell | 44, 64, 229 |
| abstract_inverted_index.from | 35 |
| abstract_inverted_index.high | 166 |
| abstract_inverted_index.lead | 290 |
| abstract_inverted_index.lung | 45 |
| abstract_inverted_index.only | 157, 193 |
| abstract_inverted_index.stem | 9, 228 |
| abstract_inverted_index.such | 231 |
| abstract_inverted_index.that | 15, 165, 244, 258, 288 |
| abstract_inverted_index.were | 69, 81, 236 |
| abstract_inverted_index.with | 144, 185, 213 |
| abstract_inverted_index.SSEA4 | 235 |
| abstract_inverted_index.aimed | 29 |
| abstract_inverted_index.assay | 79 |
| abstract_inverted_index.being | 189 |
| abstract_inverted_index.cells | 10, 37, 68, 178 |
| abstract_inverted_index.found | 238 |
| abstract_inverted_index.genes | 230 |
| abstract_inverted_index.known | 53 |
| abstract_inverted_index.model | 41 |
| abstract_inverted_index.novel | 285, 295 |
| abstract_inverted_index.study | 28, 256 |
| abstract_inverted_index.their | 85 |
| abstract_inverted_index.using | 62, 76, 278 |
| abstract_inverted_index.(A549) | 38 |
| abstract_inverted_index.(ALDH) | 94 |
| abstract_inverted_index.Hence, | 25 |
| abstract_inverted_index.Higher | 174 |
| abstract_inverted_index.NSCLC. | 300 |
| abstract_inverted_index.Sorted | 67 |
| abstract_inverted_index.better | 17, 116, 132 |
| abstract_inverted_index.bigger | 126 |
| abstract_inverted_index.cancer | 8, 21, 46 |
| abstract_inverted_index.clonal | 86 |
| abstract_inverted_index.direct | 5 |
| abstract_inverted_index.genes. | 101 |
| abstract_inverted_index.higher | 111, 137, 215 |
| abstract_inverted_index.levels | 225 |
| abstract_inverted_index.marker | 282, 287 |
| abstract_inverted_index.mostly | 119 |
| abstract_inverted_index.sorted | 50 |
| abstract_inverted_index.strong | 249 |
| abstract_inverted_index.(CSCs), | 11 |
| abstract_inverted_index.(FACS). | 66 |
| abstract_inverted_index.Through | 0 |
| abstract_inverted_index.further | 82 |
| abstract_inverted_index.greater | 171 |
| abstract_inverted_index.present | 27 |
| abstract_inverted_index.similar | 263 |
| abstract_inverted_index.sorting | 65 |
| abstract_inverted_index.(NSCLC). | 47 |
| abstract_inverted_index.(P<0.01) | 112 |
| abstract_inverted_index.activity | 95, 168 |
| abstract_inverted_index.alkaline | 92 |
| abstract_inverted_index.believed | 14 |
| abstract_inverted_index.cellular | 90, 187, 216 |
| abstract_inverted_index.compared | 155, 191, 218, 267 |
| abstract_inverted_index.detected | 159 |
| abstract_inverted_index.efficacy | 19 |
| abstract_inverted_index.elevated | 224 |
| abstract_inverted_index.findings | 105 |
| abstract_inverted_index.identify | 31 |
| abstract_inverted_index.markedly | 125 |
| abstract_inverted_index.migrated | 177 |
| abstract_inverted_index.observed | 150, 180, 205 |
| abstract_inverted_index.revealed | 109, 257 |
| abstract_inverted_index.specific | 2 |
| abstract_inverted_index.spheroid | 128 |
| abstract_inverted_index.(P<0.001) | 127 |
| abstract_inverted_index.According | 102 |
| abstract_inverted_index.achieved. | 24 |
| abstract_inverted_index.activity, | 114 |
| abstract_inverted_index.candidate | 286 |
| abstract_inverted_index.capacity. | 134 |
| abstract_inverted_index.cisplatin | 143 |
| abstract_inverted_index.comprised | 120 |
| abstract_inverted_index.confirmed | 274 |
| abstract_inverted_index.detected, | 190 |
| abstract_inverted_index.displayed | 247 |
| abstract_inverted_index.evaluated | 71 |
| abstract_inverted_index.exhibited | 115 |
| abstract_inverted_index.formation | 129 |
| abstract_inverted_index.indicated | 164 |
| abstract_inverted_index.migration | 188, 217 |
| abstract_inverted_index.similarly | 204 |
| abstract_inverted_index.targeting | 6, 297 |
| abstract_inverted_index.therapies | 296 |
| abstract_inverted_index.treatment | 18 |
| abstract_inverted_index.viability | 78 |
| abstract_inverted_index.expression | 98, 146 |
| abstract_inverted_index.holoclones | 122 |
| abstract_inverted_index.indicating | 130, 243 |
| abstract_inverted_index.migration, | 91 |
| abstract_inverted_index.percentage | 175 |
| abstract_inverted_index.relatively | 136 |
| abstract_inverted_index.resistance | 138 |
| abstract_inverted_index.conclusion, | 254 |
| abstract_inverted_index.contributed | 169 |
| abstract_inverted_index.development | 293 |
| abstract_inverted_index.feasibility | 276 |
| abstract_inverted_index.non‑small | 43 |
| abstract_inverted_index.Ιnitially, | 48 |
| abstract_inverted_index.demonstrated | 262 |
| abstract_inverted_index.self-renewal | 88, 133 |
| abstract_inverted_index.subsequently | 70 |
| abstract_inverted_index.Consistently, | 223 |
| abstract_inverted_index.characterized | 83 |
| abstract_inverted_index.dehydrogenase | 93 |
| abstract_inverted_index.pluripotency. | 252 |
| abstract_inverted_index.proliferation | 73, 113 |
| abstract_inverted_index.significantly | 110 |
| abstract_inverted_index.subpopulation | 34, 61, 108, 163, 184, 198, 212, 242, 246, 261 |
| abstract_inverted_index.5‑fluouracil | 141 |
| abstract_inverted_index.adenocarcinoma | 36 |
| abstract_inverted_index.characteristic | 250 |
| abstract_inverted_index.clonogenicity, | 117 |
| abstract_inverted_index.heterogeneity, | 87 |
| abstract_inverted_index.identification | 3 |
| abstract_inverted_index.subpopulation, | 154 |
| abstract_inverted_index.subpopulation. | 222, 271 |
| abstract_inverted_index.subpopulations | 52 |
| abstract_inverted_index.characteristics | 264 |
| abstract_inverted_index.characteristics, | 89 |
| abstract_inverted_index.characteristics. | 173 |
| abstract_inverted_index.stemness-related | 100 |
| abstract_inverted_index.triple‑negative | 59, 162, 197, 221, 270 |
| abstract_inverted_index.triple‑positive | 56, 107, 153, 183, 211, 241, 260, 280 |
| abstract_inverted_index.(EpCAM+/CD166+/CD44+) | 57, 281 |
| abstract_inverted_index.(EpCAM-/CD166-/CD44-) | 60 |
| abstract_inverted_index.fluorescence-activated | 63 |
| abstract_inverted_index.chemotherapy-resistance | 75, 172 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.85982338 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |