NSAIDs affect dendritic cell cytokine production Article Swipe
Tonke K. Raaijmakers
,
Renske J.E. van den Bijgaart
,
Gert Jan Scheffer
,
Marleen Ansems
,
Gosse J. Adema
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0275906
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0275906
Background Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor antigens in MHCI complexes to activate naïve CD8+ T cells. Analgesics, like non-steroid anti-inflammatory drugs (NSAIDs), are frequently given to cancer patients to help relieve pain, however little is known about their impact on DC function. Methods Here, we investigated the effect of the NSAIDs diclofenac, ibuprofen and celecoxib on the three key processes of DCs required for proper CD8+ cytotoxic T cell induction: antigen cross-presentation, co-stimulatory marker expression, and cytokine production. Results Our results show that TLR-induced pro- and anti-inflammatory cytokine excretion by human monocyte derived and murine bone-marrow derived DCs is diminished after NSAID exposure. Conclusions These results indicate that various NSAIDs can affect DC function and warrant further investigation into the impact of NSAIDs on DC priming of T cells and cancer immunotherapy efficacy.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0275906
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275906&type=printable
- OA Status
- gold
- Cited By
- 11
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4305040293
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https://openalex.org/W4305040293Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0275906Digital Object Identifier
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NSAIDs affect dendritic cell cytokine productionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-10-13Full publication date if available
- Authors
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Tonke K. Raaijmakers, Renske J.E. van den Bijgaart, Gert Jan Scheffer, Marleen Ansems, Gosse J. AdemaList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0275906Publisher landing page
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275906&type=printableDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0275906&type=printableDirect OA link when available
- Concepts
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Cytotoxic T cell, Cytokine, Immune system, Dendritic cell, Medicine, Immunotherapy, Cancer immunotherapy, Priming (agriculture), CD8, Immunology, T cell, Cancer research, Chemistry, Biology, In vitro, Botany, Biochemistry, GerminationTop concepts (fields/topics) attached by OpenAlex
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-
11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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71Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.complexes | 37 |
| abstract_inverted_index.cytotoxic | 94 |
| abstract_inverted_index.efficacy. | 160 |
| abstract_inverted_index.essential | 19 |
| abstract_inverted_index.excretion | 116 |
| abstract_inverted_index.exogenous | 32 |
| abstract_inverted_index.exposure. | 130 |
| abstract_inverted_index.function. | 69 |
| abstract_inverted_index.ibuprofen | 80 |
| abstract_inverted_index.patients. | 13 |
| abstract_inverted_index.processes | 87 |
| abstract_inverted_index.treatment | 10 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.anti-tumor | 23 |
| abstract_inverted_index.considered | 4 |
| abstract_inverted_index.diminished | 127 |
| abstract_inverted_index.frequently | 51 |
| abstract_inverted_index.induction: | 97 |
| abstract_inverted_index.responses, | 25 |
| abstract_inverted_index.Analgesics, | 44 |
| abstract_inverted_index.Conclusions | 131 |
| abstract_inverted_index.TLR-induced | 111 |
| abstract_inverted_index.bone-marrow | 123 |
| abstract_inverted_index.diclofenac, | 79 |
| abstract_inverted_index.expression, | 102 |
| abstract_inverted_index.non-steroid | 46 |
| abstract_inverted_index.production. | 105 |
| abstract_inverted_index.stimulating | 22 |
| abstract_inverted_index.investigated | 73 |
| abstract_inverted_index.Immunotherapy | 1 |
| abstract_inverted_index.immunotherapy | 159 |
| abstract_inverted_index.investigation | 145 |
| abstract_inverted_index.co-stimulatory | 100 |
| abstract_inverted_index.cross-presenting | 31 |
| abstract_inverted_index.anti-inflammatory | 47, 114 |
| abstract_inverted_index.cross-presentation, | 99 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5080933211, https://openalex.org/A5015323424, https://openalex.org/A5070304304, https://openalex.org/A5051425071, https://openalex.org/A5059222565 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949, https://openalex.org/I4210109357 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.74677795 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |