Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver disease Article Swipe
Brisa Rodope Alarcón‐Sánchez
,
Dafne Guerrero‐Escalera
,
Sandra Rosas‐Madrigal
,
Diana I. Aparicio‐Bautista
,
Karina Reyes‐Gordillo
,
M Lakshman
,
Arturo Ortiz‐Fernández
,
Héctor Quezada
,
Óscar Medina‐Contreras
,
Saúl Villa‐Treviño
,
Julio Isael Pérez‐Carreón
,
Jaime Arellanes‐Robledo
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/bcpt.13451
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/bcpt.13451
Alcoholic liver disease (ALD) may be attributed to multiple hits driving several alterations. The aim of this work was to determine whether nucleoredoxin (NXN) interacts with flightless‐I (FLII)/actin complex and how this ternary complex is altered during ALD progression induced by different ALD models. ALD was recapitulated in C57BL/6J female mice by the well‐known ALD Lieber‐DeCarli model, and by an in vitro human co‐culture system overexpressing NXN. The effects of ethanol and low doses of lipopolysaccharides (LPS) and diethylnitrosamine (DEN) were also evaluated in vivo as a first approach of an ALD multi‐hit protocol. We demonstrated that NXN interacts with FLII/actin complex. This complex was differentially altered in ALD in vivo and in vitro, and NXN overexpression partially reverted this alteration. We also showed that ethanol, LPS and DEN synergistically induced liver structural disarrangement, steatosis and inflammatory infiltration accompanied by increased levels of proliferation (Ki67), ethanol metabolism (CYP2E1), hepatocarcinogenesis (GSTP1) and LPS‐inducible (MYD88 and TLR4) markers. In summary, we provide evidence showing that NXN/FLII/actin complex is involved in ALD progression and that NXN might be involved in the regulation of FLII/actin‐dependent cellular functions. Moreover, we present a promising first approach of a multi‐hit protocol to better recapitulate ALD pathogenesis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/bcpt.13451
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.13451
- OA Status
- bronze
- Cited By
- 9
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3034125271
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3034125271Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/bcpt.13451Digital Object Identifier
- Title
-
Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-11Full publication date if available
- Authors
-
Brisa Rodope Alarcón‐Sánchez, Dafne Guerrero‐Escalera, Sandra Rosas‐Madrigal, Diana I. Aparicio‐Bautista, Karina Reyes‐Gordillo, M Lakshman, Arturo Ortiz‐Fernández, Héctor Quezada, Óscar Medina‐Contreras, Saúl Villa‐Treviño, Julio Isael Pérez‐Carreón, Jaime Arellanes‐RobledoList of authors in order
- Landing page
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https://doi.org/10.1111/bcpt.13451Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.13451Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.13451Direct OA link when available
- Concepts
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Alcoholic liver disease, In vivo, Actin, CYP2E1, In vitro, Cell biology, Chemistry, Biology, Biochemistry, Medicine, Genetics, Internal medicine, Microsome, CirrhosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 1, 2022: 2, 2021: 1, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5079534960 |
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| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I4210110970, https://openalex.org/I4210163111 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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