Numerical Parametric Study of Paravalvular Leak Following a Transcatheter Aortic Valve Deployment Into a Patient-Specific Aortic Root Article Swipe
Wenbin Mao
,
Qian Wang
,
Susheel Kodali
,
Wei Sun
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1115/1.4040457
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1115/1.4040457
Paravalvular leak (PVL) is a relatively frequent complication after transcatheter aortic valve replacement (TAVR) with increased mortality. Currently, there is no effective method to pre-operatively predict and prevent PVL. In this study, we developed a computational model to predict the severity of PVL after TAVR. Nonlinear finite element (FE) method was used to simulate a self-expandable CoreValve deployment into a patient-specific aortic root, specified with human material properties of aortic tissues. Subsequently, computational fluid dynamics (CFD) simulations were performed using the post-TAVR geometries from the FE simulation, and a parametric investigation of the impact of the transcatheter aortic valve (TAV) skirt shape, TAV orientation, and deployment height on PVL was conducted. The predicted PVL was in good agreement with the echocardiography data. Due to the scallop shape of CoreValve skirt, the difference of PVL due to TAV orientation can be as large as 40%. Although the stent thickness is small compared to the aortic annulus size, we found that inappropriate modeling of it can lead to an underestimation of PVL up to 10 ml/beat. Moreover, the deployment height could significantly alter the extent and the distribution of regurgitant jets, which results in a change of leaking volume up to 70%. Further investigation in a large cohort of patients is warranted to verify the accuracy of our model. This study demonstrated that a rigorously developed patient-specific computational model can provide useful insights into underlying mechanisms causing PVL and potentially assist in pre-operative planning for TAVR to minimize PVL.
Related Topics
Concepts
Cardiology
Internal medicine
Valve replacement
Medicine
Aortic root
Cardiac skeleton
Aortic valve
Radiology
Stenosis
Aorta
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1115/1.4040457
- OA Status
- green
- Cited By
- 58
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2806704746
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2806704746Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1115/1.4040457Digital Object Identifier
- Title
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Numerical Parametric Study of Paravalvular Leak Following a Transcatheter Aortic Valve Deployment Into a Patient-Specific Aortic RootWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-06-21Full publication date if available
- Authors
-
Wenbin Mao, Qian Wang, Susheel Kodali, Wei SunList of authors in order
- Landing page
-
https://doi.org/10.1115/1.4040457Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/6056191Direct OA link when available
- Concepts
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Cardiology, Internal medicine, Valve replacement, Medicine, Aortic root, Cardiac skeleton, Aortic valve, Radiology, Stenosis, AortaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
58Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 7, 2023: 12, 2022: 14, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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58Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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