Numerical Simulation of Temperature Variations during the Application of Safety Protocols in Magnetic Particle Hyperthermia Article Swipe
Gerasimos Pefanis
,
Νikolaos Μaniotis
,
Aikaterini-Rafailia Tsiapla
,
Antonios Makridis
,
Theodoros Samaras
,
M. Angelakeris
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/nano12030554
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/nano12030554
Unavoidably, magnetic particle hyperthermia is limited by the unwanted heating of the neighboring healthy tissues, due to the generation of eddy currents. Eddy currents naturally occur, due to the applied alternating magnetic field, which is used to excite the nanoparticles in the tumor and, therefore, restrict treatment efficiency in clinical application. In this work, we present two simply applicable methods for reducing the heating of healthy tissues by simultaneously keeping the heating of cancer tissue, due to magnetic nanoparticles, at an adequate level. The first method involves moving the induction coil relative to the phantom tissue during the exposure. More specifically, the coil is moving symmetrically—left and right relative to the specimen—in a bidirectional fashion. In this case, the impact of the maximum distance (2–8 cm) between the coil and the phantom is investigated. In the second method, the magnetic field is applied intermittently (in an ON/OFF pulsed mode), instead of the continuous field mode usually employed. The parameters of the intermittent field mode, such as the time intervals (ON time and OFF time) and field amplitude, are optimized based on the numerical assessment of temperature increase in healthy tissue and cancer tissue phantoms. Different ON and OFF times were tested in the range of 25–100 s and 50–200 s, respectively, and under variable field amplitudes (45–70 mT). In all the protocols studied here, the main goal is to generate inside the cancer tissue phantom the maximum temperature increase, possible (preferably within the magnetic hyperthermia window of 4–8 °C), while restricting the temperature increase in the healthy tissue phantom to below 4 °C, signifying eddy current mitigation.
Related Topics
Concepts
Electromagnetic coil
Imaging phantom
Amplitude
Hyperthermia
Materials science
Magnetic field
Eddy current
Magnetic hyperthermia
Magnetic nanoparticles
Biomedical engineering
Nuclear magnetic resonance
Hyperthermia therapy
Mechanics
Physics
Optics
Nanoparticle
Nanotechnology
Medicine
Quantum mechanics
Meteorology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nano12030554
- https://www.mdpi.com/2079-4991/12/3/554/pdf?version=1644381674
- OA Status
- gold
- Cited By
- 10
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210292765
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210292765Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nano12030554Digital Object Identifier
- Title
-
Numerical Simulation of Temperature Variations during the Application of Safety Protocols in Magnetic Particle HyperthermiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-06Full publication date if available
- Authors
-
Gerasimos Pefanis, Νikolaos Μaniotis, Aikaterini-Rafailia Tsiapla, Antonios Makridis, Theodoros Samaras, M. AngelakerisList of authors in order
- Landing page
-
https://doi.org/10.3390/nano12030554Publisher landing page
- PDF URL
-
https://www.mdpi.com/2079-4991/12/3/554/pdf?version=1644381674Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2079-4991/12/3/554/pdf?version=1644381674Direct OA link when available
- Concepts
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Electromagnetic coil, Imaging phantom, Amplitude, Hyperthermia, Materials science, Magnetic field, Eddy current, Magnetic hyperthermia, Magnetic nanoparticles, Biomedical engineering, Nuclear magnetic resonance, Hyperthermia therapy, Mechanics, Physics, Optics, Nanoparticle, Nanotechnology, Medicine, Quantum mechanics, MeteorologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4, 2023: 2, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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