NutriSighT: Interpretable Transformer Model for Dynamic Prediction of Hypocaloric Enteral Nutrition in Mechanically Ventilated Patients Article Swipe
Mateen Jangda
,
Jayshil J. Patel
,
Jaskirat Gill
,
Paul McCarthy
,
Jacob Desman
,
Rohit Gupta
,
Dhruv Patel
,
Nidhi Kavi
,
S Bakare
,
Eyal Klang
,
Robert Freeman
,
Anthony Manasia
,
John M. Oropello
,
Lili Chan
,
Mayte Suárez‐Fariñas
,
Alexander W. Charney
,
Roopa Kohli‐Seth
,
Girish N. Nadkarni
,
Ankit Sakhuja
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.01.06.25320067
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.01.06.25320067
Achieving adequate enteral nutrition among mechanically ventilated patients is challenging, yet critical. We developed NutriSighT, a transformer model using learnable positional coding to predict which patients would achieve hypocaloric nutrition between days 3-7 of mechanical ventilation. Using retrospective data from two large ICU databases (3,284 patients from AmsterdamUMCdb – development set, and 6,456 from MIMIC-IV – external validation set), we included adult patients intubated for at least 72 hours. NutriSighT achieved AUROC of 0.81 (95% CI: 0.81 – 0.82) and an AUPRC of 0.70 (95% CI: 0.70 – 0.72) on internal test set. External validation with MIMIC-IV data yielded a AUROC of 0.76 (95% CI: 0.75 – 0.76) and an AUPRC of (95% CI: 0.69 – 0.70). At a threshold of 0.5, the model achieved a 75.16% sensitivity, 60.57% specificity, 58.30% positive predictive value, and 76.88% negative predictive value. This approach may help clinicians personalize nutritional therapy among critically ill patients, improving patient outcomes.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.01.06.25320067
- OA Status
- green
- Cited By
- 1
- References
- 29
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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- Title
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NutriSighT: Interpretable Transformer Model for Dynamic Prediction of Hypocaloric Enteral Nutrition in Mechanically Ventilated PatientsWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-06Full publication date if available
- Authors
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Mateen Jangda, Jayshil J. Patel, Jaskirat Gill, Paul McCarthy, Jacob Desman, Rohit Gupta, Dhruv Patel, Nidhi Kavi, S Bakare, Eyal Klang, Robert Freeman, Anthony Manasia, John M. Oropello, Lili Chan, Mayte Suárez‐Fariñas, Alexander W. Charney, Roopa Kohli‐Seth, Girish N. Nadkarni, Ankit SakhujaList of authors in order
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https://doi.org/10.1101/2025.01.06.25320067Publisher landing page
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/11741446Direct OA link when available
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Parenteral nutrition, Enteral administration, Medicine, Intensive care medicineTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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