Obesity and Heart Failure: Mechanistic Insights and the Regulatory Role of MicroRNAs Article Swipe
Parul Sahu
,
Furkan Bestepe
,
Sezan Vehbi
,
G. Ghanem
,
Robert M. Blanton
,
Basak Icli
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/genes16060647
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/genes16060647
Heart failure (HF) remains a leading cause of morbidity and mortality worldwide, driven by diverse pathophysiological mechanisms. Among its major risk factors, obesity has emerged as a lobal public health concern affecting individuals across all age groups. The rising prevalence of obesity significantly increases the risk of cardiovascular complications, including the development and progression of HF. MicroRNAs (miRNAs), small non-coding RNA molecules, have garnered attention for their regulatory roles in cardiovascular disease, particularly through post-transcriptional modulation of gene expression. This review highlights the involvement of miRNAs in key pathological processes observed in the obese heart, including cardiac remodeling, apoptosis, angiogenesis, inflammation, mitochondrial dysfunction, and myocardial lipotoxicity. Understanding how specific miRNAs and their targets contribute to HF in the context of obesity may inform the development of novel RNA-based therapeutic strategies for cardiometabolic disease.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/genes16060647
- https://www.mdpi.com/2073-4425/16/6/647/pdf?version=1748422524
- OA Status
- gold
- Cited By
- 2
- References
- 168
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410813035
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410813035Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/genes16060647Digital Object Identifier
- Title
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Obesity and Heart Failure: Mechanistic Insights and the Regulatory Role of MicroRNAsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-28Full publication date if available
- Authors
-
Parul Sahu, Furkan Bestepe, Sezan Vehbi, G. Ghanem, Robert M. Blanton, Basak IcliList of authors in order
- Landing page
-
https://doi.org/10.3390/genes16060647Publisher landing page
- PDF URL
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https://www.mdpi.com/2073-4425/16/6/647/pdf?version=1748422524Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2073-4425/16/6/647/pdf?version=1748422524Direct OA link when available
- Concepts
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Lipotoxicity, Heart failure, microRNA, Context (archaeology), Disease, Bioinformatics, Obesity, Medicine, Inflammation, Pathological, Biology, Internal medicine, Gene, Genetics, Insulin resistance, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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168Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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