Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution? Article Swipe
Marialuisa de Ceglia
,
Juan Decara
,
Silvana Gaetani
,
Fernando Rodrı́guez de Fonseca
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ph14101002
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ph14101002
Obesity is a complex disorder, and the number of people affected is growing every day. In recent years, research has confirmed the hypothesis that food addiction is a determining factor in obesity. Food addiction is a behavioral disorder characterized by disruptions in the reward system in response to hedonic eating. The endocannabinoid system (ECS) plays an important role in the central and peripheral control of food intake and reward-related behaviors. Moreover, both obesity and food addiction have been linked to impairments in the ECS function in various brain regions integrating peripheral metabolic signals and modulating appetite. For these reasons, targeting the ECS could be a valid pharmacological therapy for these pathologies. However, targeting the cannabinoid receptors with inverse agonists failed when used in clinical contexts as a consequence of the induction of affective disorders. In this context, new classes of drugs acting either on CB1 and/or CB2 receptors or on synthetic and degradation enzymes of endogenous cannabinoids are being studied. However, further investigation is necessary to find safe and effective treatments that can exert anti-obesity effects, normalizing reward-related behaviors without causing important adverse mood effects.
Related Topics
Concepts
Endocannabinoid system
Addiction
Context (archaeology)
Reward system
Appetite
Cannabinoid receptor
Neuroscience
Obesity
Brain stimulation reward
Mood
Medicine
Psychology
Bioinformatics
Psychiatry
Receptor
Internal medicine
Central nervous system
Biology
Paleontology
Nucleus accumbens
Agonist
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph14101002
- OA Status
- gold
- Cited By
- 26
- References
- 204
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3202937234
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3202937234Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ph14101002Digital Object Identifier
- Title
-
Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?Work title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-09-29Full publication date if available
- Authors
-
Marialuisa de Ceglia, Juan Decara, Silvana Gaetani, Fernando Rodrı́guez de FonsecaList of authors in order
- Landing page
-
https://doi.org/10.3390/ph14101002Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/ph14101002Direct OA link when available
- Concepts
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Endocannabinoid system, Addiction, Context (archaeology), Reward system, Appetite, Cannabinoid receptor, Neuroscience, Obesity, Brain stimulation reward, Mood, Medicine, Psychology, Bioinformatics, Psychiatry, Receptor, Internal medicine, Central nervous system, Biology, Paleontology, Nucleus accumbens, AgonistTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
26Total citation count in OpenAlex
- Citations by year (recent)
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2025: 10, 2024: 6, 2023: 6, 2022: 4Per-year citation counts (last 5 years)
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204Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.anti-obesity | 174 |
| abstract_inverted_index.cannabinoids | 156 |
| abstract_inverted_index.pathologies. | 110 |
| abstract_inverted_index.characterized | 38 |
| abstract_inverted_index.investigation | 162 |
| abstract_inverted_index.reward-related | 68, 177 |
| abstract_inverted_index.endocannabinoid | 51 |
| abstract_inverted_index.pharmacological | 106 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5053086632, https://openalex.org/A5014291973 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I4210164724, https://openalex.org/I82767444 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5299999713897705 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.8939736 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |