Obesity is a strong risk factor for short-term mortality and adverse outcomes in Mexican patients with COVID-19: a national observational study Article Swipe
Juan Mauricio Vera-Zertuche
,
Javier Mancilla-Galindo
,
Mariana Tlalpa-Prisco
,
Patrícia Aguilar‐Alonso
,
María Magdalena Aguirre‐García
,
Orietta Segura-Badilla
,
Martín Lazcano-Hernández
,
Héctor Isaac Rocha‐González
,
Addí Rhode Navarro-Cruz
,
Ashuin Kammar‐García
,
José de Jesús Vidal-Mayo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1017/s0950268821001023
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1017/s0950268821001023
Conflicting results have been obtained through meta-analyses for the role of obesity as a risk factor for adverse outcomes in patients with coronavirus disease-2019 (COVID-19), possibly due to the inclusion of predominantly multimorbid patients with severe COVID-19. Here, we aimed to study obesity alone or in combination with other comorbidities as a risk factor for short-term all-cause mortality and other adverse outcomes in Mexican patients evaluated for suspected COVID-19 in ambulatory units and hospitals in Mexico. We performed a retrospective observational analysis in a national cohort of 71 103 patients from all 32 states of Mexico from the National COVID-19 Epidemiological Surveillance Study. Two statistical models were applied through Cox regression to create survival models and logistic regression models to determine risk of death, hospitalisation, invasive mechanical ventilation, pneumonia and admission to an intensive care unit, conferred by obesity and other comorbidities (diabetes mellitus (DM), chronic obstructive pulmonary disease, asthma, immunosuppression, hypertension, cardiovascular disease and chronic kidney disease). Models were adjusted for other risk factors. From 24 February to 26 April 2020, 71 103 patients were evaluated for suspected COVID-19; 15 529 (21.8%) had a positive test for SARS-CoV-2; 46 960 (66.1%), negative and 8614 (12.1%), pending results. Obesity alone increased adjusted mortality risk in positive patients (hazard ratio (HR) = 2.7, 95% confidence interval (CI) 2.04–2.98), but not in negative and pending-result patients. Obesity combined with other comorbidities further increased risk of death (DM: HR = 2.79, 95% CI 2.04–3.80; immunosuppression: HR = 5.06, 95% CI 2.26–11.41; hypertension: HR = 2.30, 95% CI 1.77–3.01) and other adverse outcomes. In conclusion, obesity is a strong risk factor for short-term mortality and critical illness in Mexican patients with COVID-19; risk increases when obesity is present with other comorbidities.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1017/s0950268821001023
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/30A4E59D646FA3023AFA491999EF0F0D/S0950268821001023a.pdf/div-class-title-obesity-is-a-strong-risk-factor-for-short-term-mortality-and-adverse-outcomes-in-mexican-patients-with-covid-19-a-national-observational-study-div.pdf
- OA Status
- gold
- Cited By
- 101
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3158971910
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3158971910Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1017/s0950268821001023Digital Object Identifier
- Title
-
Obesity is a strong risk factor for short-term mortality and adverse outcomes in Mexican patients with COVID-19: a national observational studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-01Full publication date if available
- Authors
-
Juan Mauricio Vera-Zertuche, Javier Mancilla-Galindo, Mariana Tlalpa-Prisco, Patrícia Aguilar‐Alonso, María Magdalena Aguirre‐García, Orietta Segura-Badilla, Martín Lazcano-Hernández, Héctor Isaac Rocha‐González, Addí Rhode Navarro-Cruz, Ashuin Kammar‐García, José de Jesús Vidal-MayoList of authors in order
- Landing page
-
https://doi.org/10.1017/s0950268821001023Publisher landing page
- PDF URL
-
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/30A4E59D646FA3023AFA491999EF0F0D/S0950268821001023a.pdf/div-class-title-obesity-is-a-strong-risk-factor-for-short-term-mortality-and-adverse-outcomes-in-mexican-patients-with-covid-19-a-national-observational-study-div.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/30A4E59D646FA3023AFA491999EF0F0D/S0950268821001023a.pdf/div-class-title-obesity-is-a-strong-risk-factor-for-short-term-mortality-and-adverse-outcomes-in-mexican-patients-with-covid-19-a-national-observational-study-div.pdfDirect OA link when available
- Concepts
-
Medicine, Hazard ratio, Internal medicine, Risk factor, Proportional hazards model, Retrospective cohort study, Obesity, Kidney disease, Intensive care unit, Comorbidity, Diabetes mellitus, Pneumonia, Cohort study, Confidence interval, Intensive care medicine, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
101Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 66, 2023: 9, 2022: 15, 2021: 10Per-year citation counts (last 5 years)
- References (count)
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47Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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