Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation ( TSPO availability) in monozygotic twin pairs discordant for BMI —Exercise training reverses increased brain activity
Article Swipe
Jaakko Hentilä
,
Jouni Tuisku
,
Ronja Ojala
,
Lihua Sun
,
Martin S. Lietzén
,
Heidi Virtanen
,
Riikka Läutamaki
,
Kalle Koskensalo
,
Lauri Nummenmaa
,
Eliisa Löyttyniemi
,
Semi Helin
,
Kirsi H. Pietiläinen
,
Jaakko Kaprio
,
Leo Lahti
,
Tarja Malm
,
Juha O. Rinne
,
Jarna C. Hannukainen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/dom.70109
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/dom.70109
Aims Obesity is associated with increased insulin‐stimulated brain glucose uptake (BGU) which is opposite to decreased GU observed in peripheral tissues. Increased BGU was shown to be reversed by weight loss and exercise training, but the mechanisms remain unknown. We investigated whether neuroinflammation (TSPO availability) and brain activity drive the obesity‐associated increase in BGU and whether this increase is reversed by exercise training. Materials and Methods Twelve monozygotic twin pairs mean age 40.4 (SD) years discordant for BMI (leaner mean 29.1 (SD) 6.3, heavier 36.7 (SD) 7.0 kg·m −2 ) performed 6‐month long exercise intervention. Insulin‐stimulated BGU during euglycaemic‐hyperinsulinaemic clamp, brain inflammation (translocator protein (TSPO) availability) and brain resting state activity were studied by [ 18 F]FDG‐PET, [ 11 C]PK11195‐PET, and fMRI, respectively. Cognitive function was assessed by an online survey. Results Exercise training had no effect on insulin‐stimulated BGU, brain neuroinflammation (TSPO availability), or BMI. Exercise improved VO 2peak , whole‐body insulin sensitivity, and cognitive function similarly in both groups (all, p <0.05) as well as decreased resting state brain activity in heavier co‐twins ( p <0.05). At baseline, heavier co‐twins had worse whole‐body insulin sensitivity ( p <0.01), increased BGU in the parietal cortex and caudatus, as well as increased resting state brain activity (both, p <0.05) and no difference in cognitive function. Leaner co‐twins had higher TSPO availability in white matter and the hippocampus ( p <0.05). Conclusions Exercise training had no effect on insulin‐stimulated BGU or neuroinflammation (TSPO availability) but it reversed increased resting state brain activity in heavier co‐twins. At baseline, obesity was associated with increased insulin‐stimulated BGU and resting state brain activity, independent of genetics.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/dom.70109
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.70109
- OA Status
- hybrid
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414085204
All OpenAlex metadata
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- DOI
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https://doi.org/10.1111/dom.70109Digital Object Identifier
- Title
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Obesity is associated with increased brain glucose uptake and activity but not neuroinflammation (
TSPO availability) in monozygotic twin pairs discordant forBMI —Exercise training reverses increased brain activityWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-10Full publication date if available
- Authors
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Jaakko Hentilä, Jouni Tuisku, Ronja Ojala, Lihua Sun, Martin S. Lietzén, Heidi Virtanen, Riikka Läutamaki, Kalle Koskensalo, Lauri Nummenmaa, Eliisa Löyttyniemi, Semi Helin, Kirsi H. Pietiläinen, Jaakko Kaprio, Leo Lahti, Tarja Malm, Juha O. Rinne, Jarna C. HannukainenList of authors in order
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https://doi.org/10.1111/dom.70109Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.70109Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.70109Direct OA link when available
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10Other works algorithmically related by OpenAlex
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