Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction Article Swipe
Hiromitsu Hattori
,
Yuko Atsumi
,
Yukiko Nakajo
,
Nobuya Aono
,
Masae Koizumi
,
Mayumi Toya
,
Hideki Igarashi
,
Koichi Kyono
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1142/s2661318221500031
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1142/s2661318221500031
Background: To evaluate obstetrical and neonatal outcomes of singletons conceived after advanced assisted reproductive technology (ART) techniques: conventional IVF pregnancies (C-IVF), ejaculated sperm intracytoplasmic sperm injection (ICSI), assisted oocyte activation (AOA), in vitro maturation (IVM), and testicular sperm extraction (TESE). Methods: The subjects were 3,028 singletons who were born after fresh or frozen embryo transfer. The subjects were separated into five groups: C-IVF ([Formula: see text]), ICSI ([Formula: see text]), AOA ([Formula: see text]), IVM ([Formula: see text]), and TESE ([Formula: see text]). We evaluated obstetrical and neonatal outcomes calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses for fresh and frozen embryos and for cleavage and blastocyst transfer. The C-IVF group was used as a background control for the ICSI group. Moreover, the TESE, AOA, and IVM groups were compared to the ICSI group to evaluate the effects of the ICSI procedure itself. Results: The incidence of perinatal complications was significantly lower in the ICSI-fresh group ([Formula: see text], 95% CI: 0.10–0.83, [Formula: see text]). Regarding sex ratio, the IVM was significantly associated with sex ratio imbalance toward female in both fresh and frozen groups ([Formula: see text], 95% CI: 0.10–0.96, [Formula: see text], 95% CI: 0.07–0.98, [Formula: see text]). On the other hand, there were no significant differences in preterm birth rate, low birth weight rate and congenital abnormalities rate between conventional IVF, ICSI, and the other groups. Conclusions: There were no negative effects on obstetrical and neonatal outcomes between conventional IVF and ICSI. Although this was a limited sample size study, advanced ART technologies such as AOA, IVM, and TESE also seem to have a low risk of adverse impact on obstetrical and neonatal outcomes but may have a slight impact on sex ratio.
Related Topics
Concepts
Intracytoplasmic sperm injection
Sperm
Medicine
Assisted reproductive technology
Andrology
In vitro fertilisation
Gynecology
Embryo transfer
Odds ratio
Live birth
Oocyte
Pregnancy
Obstetrics
Embryo
Infertility
Biology
Internal medicine
Genetics
Cell biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1142/s2661318221500031
- OA Status
- diamond
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3173601322
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3173601322Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1142/s2661318221500031Digital Object Identifier
- Title
-
Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm ExtractionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-01Full publication date if available
- Authors
-
Hiromitsu Hattori, Yuko Atsumi, Yukiko Nakajo, Nobuya Aono, Masae Koizumi, Mayumi Toya, Hideki Igarashi, Koichi KyonoList of authors in order
- Landing page
-
https://doi.org/10.1142/s2661318221500031Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1142/s2661318221500031Direct OA link when available
- Concepts
-
Intracytoplasmic sperm injection, Sperm, Medicine, Assisted reproductive technology, Andrology, In vitro fertilisation, Gynecology, Embryo transfer, Odds ratio, Live birth, Oocyte, Pregnancy, Obstetrics, Embryo, Infertility, Biology, Internal medicine, Genetics, Cell biologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3173601322 |
|---|---|
| doi | https://doi.org/10.1142/s2661318221500031 |
| ids.doi | https://doi.org/10.1142/s2661318221500031 |
| ids.mag | 3173601322 |
| ids.openalex | https://openalex.org/W3173601322 |
| fwci | 0.0 |
| type | article |
| title | Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction |
| biblio.issue | 02 |
| biblio.volume | 03 |
| biblio.last_page | 34 |
| biblio.first_page | 25 |
| topics[0].id | https://openalex.org/T11732 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2735 |
| topics[0].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[0].display_name | Assisted Reproductive Technology and Twin Pregnancy |
| topics[1].id | https://openalex.org/T10978 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2735 |
| topics[1].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[1].display_name | Prenatal Screening and Diagnostics |
| topics[2].id | https://openalex.org/T11156 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9983999729156494 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2743 |
| topics[2].subfield.display_name | Reproductive Medicine |
| topics[2].display_name | Reproductive Health and Technologies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778278907 |
| concepts[0].level | 4 |
| concepts[0].score | 0.852665901184082 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q28700 |
| concepts[0].display_name | Intracytoplasmic sperm injection |
| concepts[1].id | https://openalex.org/C2781087480 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6023128628730774 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q17145 |
| concepts[1].display_name | Sperm |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5920876264572144 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C500014431 |
| concepts[3].level | 4 |
| concepts[3].score | 0.5824158787727356 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q25862 |
| concepts[3].display_name | Assisted reproductive technology |
| concepts[4].id | https://openalex.org/C16685009 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5389976501464844 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q335057 |
| concepts[4].display_name | Andrology |
| concepts[5].id | https://openalex.org/C512716672 |
| concepts[5].level | 3 |
| concepts[5].score | 0.4961465299129486 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q200117 |
| concepts[5].display_name | In vitro fertilisation |
| concepts[6].id | https://openalex.org/C29456083 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4827705919742584 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1221899 |
| concepts[6].display_name | Gynecology |
| concepts[7].id | https://openalex.org/C160099875 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4792916178703308 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q237118 |
| concepts[7].display_name | Embryo transfer |
| concepts[8].id | https://openalex.org/C156957248 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4302731156349182 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1862216 |
| concepts[8].display_name | Odds ratio |
| concepts[9].id | https://openalex.org/C2778279030 |
| concepts[9].level | 3 |
| concepts[9].score | 0.41419267654418945 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1543380 |
| concepts[9].display_name | Live birth |
| concepts[10].id | https://openalex.org/C2776690073 |
| concepts[10].level | 3 |
| concepts[10].score | 0.4126933515071869 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q3246226 |
| concepts[10].display_name | Oocyte |
| concepts[11].id | https://openalex.org/C2779234561 |
| concepts[11].level | 2 |
| concepts[11].score | 0.3508020341396332 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11995 |
| concepts[11].display_name | Pregnancy |
| concepts[12].id | https://openalex.org/C131872663 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3505236506462097 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q5284418 |
| concepts[12].display_name | Obstetrics |
| concepts[13].id | https://openalex.org/C196843134 |
| concepts[13].level | 2 |
| concepts[13].score | 0.3226158320903778 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[13].display_name | Embryo |
| concepts[14].id | https://openalex.org/C2777688143 |
| concepts[14].level | 3 |
| concepts[14].score | 0.2551042139530182 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q179399 |
| concepts[14].display_name | Infertility |
| concepts[15].id | https://openalex.org/C86803240 |
| concepts[15].level | 0 |
| concepts[15].score | 0.2353825867176056 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[15].display_name | Biology |
| concepts[16].id | https://openalex.org/C126322002 |
| concepts[16].level | 1 |
| concepts[16].score | 0.07426720857620239 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[16].display_name | Internal medicine |
| concepts[17].id | https://openalex.org/C54355233 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[17].display_name | Genetics |
| concepts[18].id | https://openalex.org/C95444343 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[18].display_name | Cell biology |
| keywords[0].id | https://openalex.org/keywords/intracytoplasmic-sperm-injection |
| keywords[0].score | 0.852665901184082 |
| keywords[0].display_name | Intracytoplasmic sperm injection |
| keywords[1].id | https://openalex.org/keywords/sperm |
| keywords[1].score | 0.6023128628730774 |
| keywords[1].display_name | Sperm |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.5920876264572144 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/assisted-reproductive-technology |
| keywords[3].score | 0.5824158787727356 |
| keywords[3].display_name | Assisted reproductive technology |
| keywords[4].id | https://openalex.org/keywords/andrology |
| keywords[4].score | 0.5389976501464844 |
| keywords[4].display_name | Andrology |
| keywords[5].id | https://openalex.org/keywords/in-vitro-fertilisation |
| keywords[5].score | 0.4961465299129486 |
| keywords[5].display_name | In vitro fertilisation |
| keywords[6].id | https://openalex.org/keywords/gynecology |
| keywords[6].score | 0.4827705919742584 |
| keywords[6].display_name | Gynecology |
| keywords[7].id | https://openalex.org/keywords/embryo-transfer |
| keywords[7].score | 0.4792916178703308 |
| keywords[7].display_name | Embryo transfer |
| keywords[8].id | https://openalex.org/keywords/odds-ratio |
| keywords[8].score | 0.4302731156349182 |
| keywords[8].display_name | Odds ratio |
| keywords[9].id | https://openalex.org/keywords/live-birth |
| keywords[9].score | 0.41419267654418945 |
| keywords[9].display_name | Live birth |
| keywords[10].id | https://openalex.org/keywords/oocyte |
| keywords[10].score | 0.4126933515071869 |
| keywords[10].display_name | Oocyte |
| keywords[11].id | https://openalex.org/keywords/pregnancy |
| keywords[11].score | 0.3508020341396332 |
| keywords[11].display_name | Pregnancy |
| keywords[12].id | https://openalex.org/keywords/obstetrics |
| keywords[12].score | 0.3505236506462097 |
| keywords[12].display_name | Obstetrics |
| keywords[13].id | https://openalex.org/keywords/embryo |
| keywords[13].score | 0.3226158320903778 |
| keywords[13].display_name | Embryo |
| keywords[14].id | https://openalex.org/keywords/infertility |
| keywords[14].score | 0.2551042139530182 |
| keywords[14].display_name | Infertility |
| keywords[15].id | https://openalex.org/keywords/biology |
| keywords[15].score | 0.2353825867176056 |
| keywords[15].display_name | Biology |
| keywords[16].id | https://openalex.org/keywords/internal-medicine |
| keywords[16].score | 0.07426720857620239 |
| keywords[16].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1142/s2661318221500031 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210193017 |
| locations[0].source.issn | 2661-3174, 2661-3182 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2661-3174 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Fertility & Reproduction |
| locations[0].source.host_organization | https://openalex.org/P4310319815 |
| locations[0].source.host_organization_name | World Scientific |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319815 |
| locations[0].source.host_organization_lineage_names | World Scientific |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Fertility & Reproduction |
| locations[0].landing_page_url | https://doi.org/10.1142/s2661318221500031 |
| locations[1].id | pmh:oai:doaj.org/article:8816206bc26a434a972272fbb449a4d4 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S4306401280 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | cc-by-sa |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | article |
| locations[1].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Fertility & Reproduction, Vol 3, Iss 2, Pp 25-34 (2021) |
| locations[1].landing_page_url | https://doaj.org/article/8816206bc26a434a972272fbb449a4d4 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5119824589 |
| authorships[0].author.orcid | https://orcid.org/0009-0001-0522-7760 |
| authorships[0].author.display_name | Hiromitsu Hattori |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[0].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I181637171 |
| authorships[0].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Musashino Art University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hiromitsu Hattori |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[1].author.id | https://openalex.org/A5032331488 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Yuko Atsumi |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[1].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I181637171 |
| authorships[1].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Musashino Art University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yuko Atsumi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[2].author.id | https://openalex.org/A5111631819 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Yukiko Nakajo |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[2].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I181637171 |
| authorships[2].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Musashino Art University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yukiko Nakajo |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[3].author.id | https://openalex.org/A5074726054 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Nobuya Aono |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[3].affiliations[0].raw_affiliation_string | Kyono ART Clinic Takanawa, Takanawa Court 5F, 3-13-1, Takanawa, Minatoku, Tokyo, 108-0074, Japan |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I181637171 |
| authorships[3].affiliations[1].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I181637171 |
| authorships[3].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Musashino Art University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nobuya Aono |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan, Kyono ART Clinic Takanawa, Takanawa Court 5F, 3-13-1, Takanawa, Minatoku, Tokyo, 108-0074, Japan |
| authorships[4].author.id | https://openalex.org/A5062387242 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Masae Koizumi |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[4].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I181637171 |
| authorships[4].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Musashino Art University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Masae Koizumi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[5].author.id | https://openalex.org/A5105302540 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Mayumi Toya |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[5].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I181637171 |
| authorships[5].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Musashino Art University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mayumi Toya |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[6].author.id | https://openalex.org/A5056415319 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-3478-497X |
| authorships[6].author.display_name | Hideki Igarashi |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[6].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[6].institutions[0].id | https://openalex.org/I181637171 |
| authorships[6].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Musashino Art University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Hideki Igarashi |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[7].author.id | https://openalex.org/A5010918405 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5211-7778 |
| authorships[7].author.display_name | Koichi Kyono |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I181637171 |
| authorships[7].affiliations[0].raw_affiliation_string | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I181637171 |
| authorships[7].affiliations[1].raw_affiliation_string | Kyono ART Clinic Takanawa, Takanawa Court 5F, 3-13-1, Takanawa, Minatoku, Tokyo, 108-0074, Japan |
| authorships[7].institutions[0].id | https://openalex.org/I181637171 |
| authorships[7].institutions[0].ror | https://ror.org/04qdzzb42 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I181637171 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Musashino Art University |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Koichi Kyono |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Kyono ART Clinic Sendai, 1-1-1 3F, Honcho, Aobaku, Sendai, Miyagi, 980-0014, Japan, Kyono ART Clinic Takanawa, Takanawa Court 5F, 3-13-1, Takanawa, Minatoku, Tokyo, 108-0074, Japan |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1142/s2661318221500031 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Obstetrical and Neonatal Outcomes of 3,028 Singletons Born After Advanced ART Techniques: Ejaculated Sperm Intracytoplasmic Sperm Injection, Artificial Oocyte Activation, in Vitro Maturation and Testicular Sperm Extraction |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11732 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2735 |
| primary_topic.subfield.display_name | Pediatrics, Perinatology and Child Health |
| primary_topic.display_name | Assisted Reproductive Technology and Twin Pregnancy |
| related_works | https://openalex.org/W2140432911, https://openalex.org/W4251731324, https://openalex.org/W2157787264, https://openalex.org/W2380508976, https://openalex.org/W3193044879, https://openalex.org/W2469170411, https://openalex.org/W1419954776, https://openalex.org/W2039581654, https://openalex.org/W2019137577, https://openalex.org/W2037208728 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1142/s2661318221500031 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210193017 |
| best_oa_location.source.issn | 2661-3174, 2661-3182 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2661-3174 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Fertility & Reproduction |
| best_oa_location.source.host_organization | https://openalex.org/P4310319815 |
| best_oa_location.source.host_organization_name | World Scientific |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319815 |
| best_oa_location.source.host_organization_lineage_names | World Scientific |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Fertility & Reproduction |
| best_oa_location.landing_page_url | https://doi.org/10.1142/s2661318221500031 |
| primary_location.id | doi:10.1142/s2661318221500031 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210193017 |
| primary_location.source.issn | 2661-3174, 2661-3182 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2661-3174 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Fertility & Reproduction |
| primary_location.source.host_organization | https://openalex.org/P4310319815 |
| primary_location.source.host_organization_name | World Scientific |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319815 |
| primary_location.source.host_organization_lineage_names | World Scientific |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Fertility & Reproduction |
| primary_location.landing_page_url | https://doi.org/10.1142/s2661318221500031 |
| publication_date | 2021-06-01 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2030709712, https://openalex.org/W3118601047, https://openalex.org/W2528136357, https://openalex.org/W2129259025, https://openalex.org/W1995057744, https://openalex.org/W2020237091, https://openalex.org/W2756300507, https://openalex.org/W3116126765, https://openalex.org/W2012218412, https://openalex.org/W2155835604, https://openalex.org/W2366486042, https://openalex.org/W2793016399, https://openalex.org/W2125726311, https://openalex.org/W2922063450, https://openalex.org/W1966186977, https://openalex.org/W2399980280, https://openalex.org/W3011387178, https://openalex.org/W2301171262, https://openalex.org/W2002315793, https://openalex.org/W2078940065, https://openalex.org/W2058472893, https://openalex.org/W2084444116, https://openalex.org/W3111096094, https://openalex.org/W1977892756, https://openalex.org/W2134689931, https://openalex.org/W2885433469, https://openalex.org/W2785490505, https://openalex.org/W1996431759, https://openalex.org/W2773875190, https://openalex.org/W2140535499, https://openalex.org/W2611240090, https://openalex.org/W2035118720, https://openalex.org/W2118109154, https://openalex.org/W2161759984, https://openalex.org/W2306746538, https://openalex.org/W3118347155, https://openalex.org/W2182606439, https://openalex.org/W2965484888, https://openalex.org/W2597814839 |
| referenced_works_count | 39 |
| abstract_inverted_index.a | 117, 251, 269, 283 |
| abstract_inverted_index.On | 203 |
| abstract_inverted_index.To | 1 |
| abstract_inverted_index.We | 83 |
| abstract_inverted_index.as | 116, 260 |
| abstract_inverted_index.in | 31, 155, 182, 212 |
| abstract_inverted_index.no | 209, 235 |
| abstract_inverted_index.of | 7, 141, 149, 272 |
| abstract_inverted_index.on | 238, 275, 286 |
| abstract_inverted_index.or | 51 |
| abstract_inverted_index.to | 133, 137, 267 |
| abstract_inverted_index.95% | 162, 191, 197 |
| abstract_inverted_index.AOA | 70 |
| abstract_inverted_index.ART | 257 |
| abstract_inverted_index.CI: | 163, 192, 198 |
| abstract_inverted_index.IVF | 18, 245 |
| abstract_inverted_index.IVM | 74, 129, 172 |
| abstract_inverted_index.The | 41, 55, 111, 147 |
| abstract_inverted_index.and | 4, 35, 78, 86, 102, 105, 108, 128, 185, 220, 228, 240, 246, 263, 277 |
| abstract_inverted_index.but | 280 |
| abstract_inverted_index.for | 100, 106, 120 |
| abstract_inverted_index.low | 216, 270 |
| abstract_inverted_index.may | 281 |
| abstract_inverted_index.see | 64, 68, 72, 76, 81, 160, 166, 189, 195, 201 |
| abstract_inverted_index.sex | 169, 177, 287 |
| abstract_inverted_index.the | 90, 121, 125, 134, 139, 142, 156, 171, 204, 229 |
| abstract_inverted_index.was | 114, 152, 173, 250 |
| abstract_inverted_index.who | 46 |
| abstract_inverted_index.AOA, | 127, 261 |
| abstract_inverted_index.ICSI | 66, 122, 135, 143 |
| abstract_inverted_index.IVF, | 226 |
| abstract_inverted_index.IVM, | 262 |
| abstract_inverted_index.TESE | 79, 264 |
| abstract_inverted_index.also | 265 |
| abstract_inverted_index.born | 48 |
| abstract_inverted_index.both | 183 |
| abstract_inverted_index.five | 60 |
| abstract_inverted_index.have | 268, 282 |
| abstract_inverted_index.into | 59 |
| abstract_inverted_index.odds | 92 |
| abstract_inverted_index.rate | 219, 223 |
| abstract_inverted_index.risk | 271 |
| abstract_inverted_index.seem | 266 |
| abstract_inverted_index.size | 254 |
| abstract_inverted_index.such | 259 |
| abstract_inverted_index.this | 249 |
| abstract_inverted_index.used | 115 |
| abstract_inverted_index.were | 43, 47, 57, 131, 208, 234 |
| abstract_inverted_index.with | 176 |
| abstract_inverted_index.(AOR) | 94 |
| abstract_inverted_index.(ART) | 15 |
| abstract_inverted_index.3,028 | 44 |
| abstract_inverted_index.C-IVF | 62, 112 |
| abstract_inverted_index.ICSI, | 227 |
| abstract_inverted_index.ICSI. | 247 |
| abstract_inverted_index.TESE, | 126 |
| abstract_inverted_index.There | 233 |
| abstract_inverted_index.after | 10, 49 |
| abstract_inverted_index.birth | 214, 217 |
| abstract_inverted_index.fresh | 50, 101, 184 |
| abstract_inverted_index.group | 113, 136, 158 |
| abstract_inverted_index.hand, | 206 |
| abstract_inverted_index.lower | 154 |
| abstract_inverted_index.other | 205, 230 |
| abstract_inverted_index.rate, | 215 |
| abstract_inverted_index.ratio | 93, 178 |
| abstract_inverted_index.sperm | 22, 24, 37 |
| abstract_inverted_index.there | 207 |
| abstract_inverted_index.using | 95 |
| abstract_inverted_index.vitro | 32 |
| abstract_inverted_index.(AOA), | 30 |
| abstract_inverted_index.(IVM), | 34 |
| abstract_inverted_index.embryo | 53 |
| abstract_inverted_index.female | 181 |
| abstract_inverted_index.frozen | 52, 103, 186 |
| abstract_inverted_index.group. | 123 |
| abstract_inverted_index.groups | 130, 187 |
| abstract_inverted_index.impact | 274, 285 |
| abstract_inverted_index.oocyte | 28 |
| abstract_inverted_index.ratio, | 170 |
| abstract_inverted_index.ratio. | 288 |
| abstract_inverted_index.sample | 253 |
| abstract_inverted_index.slight | 284 |
| abstract_inverted_index.study, | 255 |
| abstract_inverted_index.text], | 161, 190, 196 |
| abstract_inverted_index.toward | 180 |
| abstract_inverted_index.weight | 218 |
| abstract_inverted_index.(ICSI), | 26 |
| abstract_inverted_index.(TESE). | 39 |
| abstract_inverted_index.adverse | 273 |
| abstract_inverted_index.between | 224, 243 |
| abstract_inverted_index.control | 119 |
| abstract_inverted_index.effects | 140, 237 |
| abstract_inverted_index.embryos | 104 |
| abstract_inverted_index.groups. | 231 |
| abstract_inverted_index.groups: | 61 |
| abstract_inverted_index.itself. | 145 |
| abstract_inverted_index.limited | 252 |
| abstract_inverted_index.preterm | 213 |
| abstract_inverted_index.text]), | 65, 69, 73, 77 |
| abstract_inverted_index.text]). | 82, 167, 202 |
| abstract_inverted_index.(C-IVF), | 20 |
| abstract_inverted_index.Although | 248 |
| abstract_inverted_index.Methods: | 40 |
| abstract_inverted_index.Results: | 146 |
| abstract_inverted_index.adjusted | 91 |
| abstract_inverted_index.advanced | 11, 256 |
| abstract_inverted_index.analyses | 99 |
| abstract_inverted_index.assisted | 12, 27 |
| abstract_inverted_index.cleavage | 107 |
| abstract_inverted_index.compared | 132 |
| abstract_inverted_index.evaluate | 2, 138 |
| abstract_inverted_index.logistic | 97 |
| abstract_inverted_index.negative | 236 |
| abstract_inverted_index.neonatal | 5, 87, 241, 278 |
| abstract_inverted_index.outcomes | 6, 88, 242, 279 |
| abstract_inverted_index.subjects | 42, 56 |
| abstract_inverted_index.Moreover, | 124 |
| abstract_inverted_index.Regarding | 168 |
| abstract_inverted_index.[Formula: | 165, 194, 200 |
| abstract_inverted_index.conceived | 9 |
| abstract_inverted_index.evaluated | 84 |
| abstract_inverted_index.imbalance | 179 |
| abstract_inverted_index.incidence | 148 |
| abstract_inverted_index.injection | 25 |
| abstract_inverted_index.perinatal | 150 |
| abstract_inverted_index.procedure | 144 |
| abstract_inverted_index.separated | 58 |
| abstract_inverted_index.transfer. | 54, 110 |
| abstract_inverted_index.([Formula: | 63, 67, 71, 75, 80, 159, 188 |
| abstract_inverted_index.ICSI-fresh | 157 |
| abstract_inverted_index.activation | 29 |
| abstract_inverted_index.associated | 175 |
| abstract_inverted_index.background | 118 |
| abstract_inverted_index.blastocyst | 109 |
| abstract_inverted_index.congenital | 221 |
| abstract_inverted_index.ejaculated | 21 |
| abstract_inverted_index.extraction | 38 |
| abstract_inverted_index.maturation | 33 |
| abstract_inverted_index.regression | 98 |
| abstract_inverted_index.singletons | 8, 45 |
| abstract_inverted_index.technology | 14 |
| abstract_inverted_index.testicular | 36 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.calculating | 89 |
| abstract_inverted_index.differences | 211 |
| abstract_inverted_index.obstetrical | 3, 85, 239, 276 |
| abstract_inverted_index.pregnancies | 19 |
| abstract_inverted_index.significant | 210 |
| abstract_inverted_index.techniques: | 16 |
| abstract_inverted_index.0.07–0.98, | 199 |
| abstract_inverted_index.0.10–0.83, | 164 |
| abstract_inverted_index.0.10–0.96, | 193 |
| abstract_inverted_index.Conclusions: | 232 |
| abstract_inverted_index.conventional | 17, 225, 244 |
| abstract_inverted_index.reproductive | 13 |
| abstract_inverted_index.technologies | 258 |
| abstract_inverted_index.abnormalities | 222 |
| abstract_inverted_index.complications | 151 |
| abstract_inverted_index.multivariable | 96 |
| abstract_inverted_index.significantly | 153, 174 |
| abstract_inverted_index.intracytoplasmic | 23 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5010918405 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I181637171 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.550000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.08306025 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |