Ocular Drug Delivery: Emerging Approaches and Advances Article Swipe
Shilpkala Gade
,
Yin So
,
Deepakkumar Mishra
,
Shubhamkumar M. Baviskar
,
Ahmad A. Assiri
,
Katie Glover
,
Ravi Sheshala
,
Lalitkumar K. Vora
,
Thakur Raghu Raj Singh
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics17050599
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics17050599
Complex anatomical and physiological barriers make the eye a challenging organ to treat from a drug delivery perspective. Currently available treatment methods (topical eyedrops) for anterior segment diseases pose several limitations in terms of bioavailability and patient compliance. Conventional drug delivery methods to treat posterior segment ocular diseases are primarily intravitreal injection (IVT) of solutions. IVT is highly invasive and leads to retinal toxicity, endophthalmitis, and intraocular inflammation, frequently requiring professional administration and frequent clinical visits. Advanced drug delivery treatment strategies could improve patient compliance and convenience. Long-acting drug delivery platforms (biodegradable or nonbiodegradable) provide sustained/controlled release of drugs for at least four to six months. Smart drug delivery alternatives, for instance, in situ forming implants, are injectable formulations that form semisolid-to-solid implants in response to the various stimuli of pH, light, osmolarity, and temperature. Additionally, nanoparticulate drug delivery systems, contact lenses, electrospun patches, and microneedle-based drug delivery systems provide minimally invasive treatment options for ocular disorders. This comprehensive review focuses on advanced drug delivery options for the management of ocular disorders.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics17050599
- OA Status
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- Cited By
- 3
- References
- 139
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.3390/pharmaceutics17050599Digital Object Identifier
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Ocular Drug Delivery: Emerging Approaches and AdvancesWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-05-01Full publication date if available
- Authors
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Shilpkala Gade, Yin So, Deepakkumar Mishra, Shubhamkumar M. Baviskar, Ahmad A. Assiri, Katie Glover, Ravi Sheshala, Lalitkumar K. Vora, Thakur Raghu Raj SinghList of authors in order
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goldOpen access status per OpenAlex
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Drug delivery, Medicine, Drug, Posterior segment of eyeball, Intensive care medicine, Endophthalmitis, Pharmacology, Ophthalmology, Nanotechnology, Materials scienceTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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