Off-label use of olaparib in uncommon tumor locations in patients with impaired homologous recombination genes Article Swipe

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Héctor Carlos García-Díaz , María Larrosa-Garcia , J Gómez-Alonso , Mara Cruellas , Enriqueta Felip , Teresa Macarulla , Anna Farriols , Maria J Carreras ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.farma.2025.02.010

There is limited published evidence on the use of olaparib in patients harboring pathogenic variants other than breast cancer genes, like PALB2 and ATM and conditions different than those authorized such as digestive tract, neuroendocrine and lung tumors. Further research is to assess the efficacy of olaparib in these patients.

Related Topics

Medicine

Homologous Chromosome

Biology

Reverse Transcription Polymerase Chain Reaction

Concepts

Olaparib Homologous recombination Medicine Gene Homologous chromosome Recombination Genetics Biology Poly ADP ribose polymerase Polymerase

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.farma.2025.02.010
OA Status: gold
References: 26
Related Works: 10
OpenAlex ID: https://openalex.org/W4408957802

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OpenAlex ID: https://openalex.org/W4408957802

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DOI: https://doi.org/10.1016/j.farma.2025.02.010

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Title: Off-label use of olaparib in uncommon tumor locations in patients with impaired homologous recombination genes

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-03-29

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Authors: Héctor Carlos García-Díaz, María Larrosa-Garcia, J Gómez-Alonso, Mara Cruellas, Enriqueta Felip, Teresa Macarulla, Anna Farriols, Maria J Carreras

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Landing page: https://doi.org/10.1016/j.farma.2025.02.010

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Open access: Yes

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OA status: gold

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OA URL: https://doi.org/10.1016/j.farma.2025.02.010

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Concepts: Olaparib, Homologous recombination, Medicine, Gene, Homologous chromosome, Recombination, Genetics, Biology, Poly ADP ribose polymerase, Polymerase

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Cited by: 0

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References (count): 26

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Related works (count): 10

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