Olanzapine-Induced Therapeutic Hypothermia Attenuates Renal Injury in Rats after Asphyxial Cardiac Arrest and Resuscitation Article Swipe
Tsendsuren Tungalag
,
Yeo-Jin Yoo
,
Hyun‐Jin Tae
,
Dong Kwon Yang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11030443
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11030443
Return of spontaneous circulation (ROSC) through cardiopulmonary resuscitation (CPR) after cardiac arrest (CA) causes post-cardiac arrest syndrome (PCAS) due to dysfunction in various organs, which provokes acute kidney injury because of renal ischemia-reperfusion injury. Therapeutic hypothermia (TH) can reduce PCAS after CA and ROSC. However, it needs to be more sophisticated and effective. Hence, we aimed to elucidate the protective effects of olanzapine-induced TH against renal injury in asphyxial CA-induced rats. Every rat’s body temperature was maintained at 33 °C for 6 h after administering olanzapine post-CA and ROSC. Olanzapine-induced TH dramatically increased the survival rate of the rats and ameliorated renal tissue damage. Moreover, it suppressed oxidative stress responses through preservation of mitochondrial function and endoplasmic reticulum stress as the main contributor of oxidative stress. Notably, these actions of olanzapine-induced TH were mediated through the Sirt3-related signaling pathway, including the maintenance of Sirt3 and FOXO3a protein expression and the activation of AMPKα and superoxide dismutase 1 (SOD2, a mitochondrial antioxidant). This study is the first to disclose the protective effects of olanzapine-induced TH against renal injury after CA and ROSC, suggesting that olanzapine-induced TH could be utilized for treating CA followed by ROSC.
Related Topics
Concepts
Medicine
Hypothermia
Oxidative stress
Olanzapine
Pharmacology
SIRT3
SOD2
Anesthesia
Cardiopulmonary resuscitation
Reperfusion injury
Ischemia
Endocrinology
Internal medicine
Resuscitation
Superoxide dismutase
Chemistry
Schizophrenia (object-oriented programming)
Gene
Acetylation
Psychiatry
Biochemistry
Sirtuin
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox11030443
- https://www.mdpi.com/2076-3921/11/3/443/pdf?version=1645611678
- OA Status
- gold
- Cited By
- 7
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4212989759
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4212989759Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox11030443Digital Object Identifier
- Title
-
Olanzapine-Induced Therapeutic Hypothermia Attenuates Renal Injury in Rats after Asphyxial Cardiac Arrest and ResuscitationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-23Full publication date if available
- Authors
-
Tsendsuren Tungalag, Yeo-Jin Yoo, Hyun‐Jin Tae, Dong Kwon YangList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox11030443Publisher landing page
- PDF URL
-
https://www.mdpi.com/2076-3921/11/3/443/pdf?version=1645611678Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2076-3921/11/3/443/pdf?version=1645611678Direct OA link when available
- Concepts
-
Medicine, Hypothermia, Oxidative stress, Olanzapine, Pharmacology, SIRT3, SOD2, Anesthesia, Cardiopulmonary resuscitation, Reperfusion injury, Ischemia, Endocrinology, Internal medicine, Resuscitation, Superoxide dismutase, Chemistry, Schizophrenia (object-oriented programming), Gene, Acetylation, Psychiatry, Biochemistry, SirtuinTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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