On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy Article Swipe

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Yolanda Prezado , Charlotte Lamirault , Thibaut Larcher , Cristèle Gilbert , Julie Espenon , A. Patriarca , Ludovic De Marzi , Angela Corvino , Ramón Ortiz , Marjorie Juchaux ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.radonc.2025.110769

While our study does not exclude the relevant role of the valley dose in tissue sparing, it does highlight the importance of peak doses, contradicting previous assumptions. Our results agree with the conclusion of a recent retrospective evaluation of preclinical studies in micro and minibeam radiation therapy.

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Proton therapy Radiation therapy Toxicity Medicine Nuclear medicine Proton Oncology Radiology Internal medicine Physics Nuclear physics

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.radonc.2025.110769
OA Status: hybrid
Cited By: 2
References: 23
Related Works: 10
OpenAlex ID: https://openalex.org/W4407366300

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DOI: https://doi.org/10.1016/j.radonc.2025.110769

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Title: On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-02-11

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Authors: Yolanda Prezado, Charlotte Lamirault, Thibaut Larcher, Cristèle Gilbert, Julie Espenon, A. Patriarca, Ludovic De Marzi, Angela Corvino, Ramón Ortiz, Marjorie Juchaux

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Landing page: https://doi.org/10.1016/j.radonc.2025.110769

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OA URL: https://doi.org/10.1016/j.radonc.2025.110769

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Concepts: Proton therapy, Radiation therapy, Toxicity, Medicine, Nuclear medicine, Proton, Oncology, Radiology, Internal medicine, Physics, Nuclear physics

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Cited by: 2

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